Influence of Korean pine (Pinus koraiensis)-seed oil containingcis-5,cis-9,cis-12-octadecatrienoic acid on polyunsaturated fatty acid metabolism, eicosanoid production and blood pressure of rats

Abstract

The effects of dietary Korean pine (Pinus koraiensis)-seed oil containing a peculiar trienoic acid (cis-5, cis+9,cis-1218:3, pinolenic acid, approximately 18%) on various lipid variables were compared in rats with those of flaxseed (Linum usitatissimum L.) oil, safflower (Curthamus rinctorius L.) oil and evening primrose (Oenotkra biemis L.) oil under experimental conditions where the effects of different polyunsaturated fatty acids could be estimated. In Sprague-Dawley rats fed on diets containing 100 g fat and 5 g cholesterol/kg, the hypocholesterolaemic activity of pinolenic acid was intermediate between a-linolenic and linoleic acids. Analysis of the fatty acid composition of liver phosphatidylcholine indicated that, in contrast to a-linolenic acid, pinolenic acid does not interfere with the desaturation of linoleic acid to arachidonic acid. However, the effects on ADP-induced platelet aggregation and aortic prostacyclin production were comparable. When spontaneously hypertensive rats were fed on diets containing 100 g fat/kg but free of cholesterol, y-liwlenic and pinolenic acids, as compared with liwleic acid, increased prostacyclin production and tended to reduce platelet aggregation. In addition, pinolenic acid attenuated the elevation of blood pressure after 5 weeks of feeding. Thus, the results of the present studies indicate the beneficial effects of pinolenic acid on various lipid variables.

<i>Pinus koraiensis</i> seed oil (PinnoThin^TM) supplementation reduces body weight gain and lipid concentration in liver and plasma of mice

“…Comparatively less is known in the case of some unusual PUFA, like pinolenic acid (Imbs et al, 1998). The Pinus koraiensis seed oil, containing a significant amount of pinolenic acid, has been studied relatively little and investigations on its effects on lipid metabolism are only preliminary (Sugano et al, 1994;Ide et al, 1995;Asset et al, 1999;Lee et al, 2004).…”

“…Previous studies, mainly carried out on animal models such as rats, revealed that a diet enriched with pine nut oil had some benefi cial effects infl uencing, in particular, haematic lipid parameters (Sugano et al, 1994;Asset et al, 1999). Some uncertainty, however, still exists regarding the hypolipidaemic properties of this oil.…”

“…Some uncertainty, however, still exists regarding the hypolipidaemic properties of this oil. In addition, a possible infl uence of pine nut oil on body weight gain of treated animals was never observed (Sugano et al, 1994;Matsuo et al, 1996;Asset et al, 1999). The supplementation of the diet with pine nut oil therefore requires further investigation both for its nutritional properties and for the molecular mechanisms by which this fat infl uences lipid metabolism.…”

“…Vegetable oils from the seeds of some conifers , such as Pinus pinaster and Pinus koraiensis, are currently under investigation for their use in the feed industry and/or as dietary supplements (Sugano et al, 1994; HYPOLIPIDEMIC PROPERTIES OF PINE NUT OIL (PINNOTHIN TM ) al., 1999; Lee et al, 2004). These oils contain, to a certain degree, some unusual polyunsaturated fatty acids (PUFA) which are characterized by polymethyleneinterrupted double bonds.…”

Chemical Composition of Pinus koraiensis Seed and Its Biological Activity

“…P. koraiensis seeds, nuts and cones are enriched with essential oil with antibacterial and fungal [1] and antiplatelet aggregation activities [2]. Recently, Kim et al evaluated the antihyperlipidemic activities of the essential oil from the leaves of P. koraiensis SIEB (EOPK) that has been used as a folk remedy for heart disease.…”