Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma

Porta, Miquel; Pumarega, José; Amaral, André F.S.; Genkinger, Jeanine M.; Camargo, Judit; Mucci, Lorelei A.; Alguacil, Juan; Gasull, Magda; Zhang, Xuehong; Morales, Eva; Iglesias, Mar; Ogino, Shuji; Engel, Lawrence S.

doi:10.1016/j.envres.2020.109781

Cited by 7 publications

(12 citation statements)

References 98 publications

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“…Methods of the PANKRAS II study have been previously described (Gómez-Tomás et al 2019 ; Camargo et al 2019 ; Amaral et al 2012 ; Porta et al 2007 , 2008 , 2009 , 2005 , 2020 , 1999 , 2000 ; Crous-Bou 2009 ; Soler et al 1999 ). Briefly, subject recruitment took place between 1992 and 1995 at five general hospitals in the Mediterranean part of Spain, where 185 incident cases of PDAC were prospectively identified.…”

Section: Methodsmentioning

confidence: 99%

“…The present report is based on 118 incident cases of PDAC with toenail samples obtained and metal concentrations analyzed (Amaral et al 2012 ). There were no significant differences between the 118 patients with and the 67 patients without available trace elements concentrations for a broad range of sociodemographic and clinical variables, including age, sex, social class, education, occupation, smoking, coffee consumption, duration of interview, interval from first symptom of pancreatic cancer to diagnosis, and interval from first symptom to blood extraction (Gómez-Tomás et al 2019 ; Camargo et al 2019 ; Porta et al 2020 ) (Supplementary Table 1). The Ethics Committees of participating hospitals approved the study protocol, and patients gave informed consent to be included in the study.…”

Section: Methodsmentioning

confidence: 99%

“…A structured form was used to collect clinicopathological information from medical records, including details on semiology, diagnostic procedures, laboratory results and follow-up (Soler et al 1999 ; Porta et al 2000 ). Follow-up extended for 17.5 years (Porta et al 2020 ). Hospital discharge diagnoses and the tumor clinical stage were also recorded.…”

Section: Methodsmentioning

confidence: 99%

“…When a diagnostic procedure was performed more than once, the physician who abstracted the data chose the more informative result. Over 88% of the PDAC patients were interviewed face-to-face by trained monitors during their hospital stay, close to the time of diagnosis (Camargo et al 2019 ; Amaral et al 2012 ; Porta et al 2020 ).…”

Section: Methodsmentioning

confidence: 99%

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Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias

et al. 2021

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Trace elements such as cadmium, arsenic, zinc or selenium increase or decrease risk of a wide range of human diseases. Their levels in toenails may provide a measure of mid-term intake of trace elements for studies in humans. However, in biologically and clinically aggressive diseases as pancreatic cancer, the progression of the disease could modify such concentrations and produce reverse causation bias. The aim was to analyze the influence of specific time intervals between several clinical events and the collection of toenails upon concentrations of trace elements in patients with pancreatic cancer. Subjects were 118 incident cases of pancreatic adenocarcinoma prospectively recruited in eastern Spain. Toenails were collected at cancer diagnosis, and soon thereafter interviews were conducted. Information on cancer signs and symptoms was obtained from medical records and patient interviews. Levels of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. General linear models adjusting for potential confounders were applied to analyze relations between log concentrations of trace elements and the time intervals, including the interval from first symptom of cancer to toenail collection (iST). Toenail concentrations of the 12 trace elements were weakly or not influenced by the progression of the disease or the diagnostic procedures. Concentrations of aluminum were slightly higher in subjects with a longer iST (age, sex and stage adjusted geometric means: 11.44 vs. 7.75 µg/g for iST > 120 days vs. ≤ 40 days). There was a weak inverse relation of iST with concentrations of zinc and selenium (maximum differences of about 20 and 0.08 µg/g, respectively). Conclusions: concentrations of the trace elements were weakly or not influenced by the development of the disease before toenail collection. Only concentrations of aluminum increased slightly with increasing iST, whereas levels of zinc and selenium decreased weakly. Even in an aggressive disease as pancreatic cancer, toenail concentrations of trace elements may provide a valid measure of mid-term intake of trace elements, unaffected by clinical events and disease progression. Supplementary Information The online version contains supplementary material available at 10.1007/s12403-021-00436-2.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias

et al. 2021

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“…Camargo et al also reported that PaC patients occupationally exposed to certain chemical agents or mixtures (e.g., aromatic hydrocarbon solvents and pesticides) had higher concentrations of heavy metals such as Cd, Pb, V, Mn, and As in toenails, suggesting that these elements may account for some of the occupational risks for PaC [ 149 ]. Two recent ionomic studies investigated the complex relationship among trace elements in toenails, KRAS mutations, and survival in pancreatic ductal adenocarcinoma (PDAC, the most common form of PaC), which not only suggested a special role for several trace elements (such as Ni and Mn) in pancreatic and perhaps other cancers with KRAS mutations, but also found a strong association between higher toenail concentrations of heavy metals (such as Pb, Cd, As, and V) and better survival of PDAC [ 150 , 151 ]. In addition, a very recent urine ionomic study of PDAC showed remarkable differences for several essential metals (including significantly lower levels of Ca and Mg and higher levels of Cu and Zn in PDAC), implying that ionomics is a promising approach for discovery of early diagnostic markers for PDAC [ 91 ].…”

Section: Ionomics Of Complex Diseasementioning

confidence: 99%

Disease Ionomics: Understanding the Role of Ions in Complex Disease

Zhang

Zheng

2020

IJMS

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Ionomics is a novel multidisciplinary field that uses advanced techniques to investigate the composition and distribution of all minerals and trace elements in a living organism and their variations under diverse physiological and pathological conditions. It involves both high-throughput elemental profiling technologies and bioinformatic methods, providing opportunities to study the molecular mechanism underlying the metabolism, homeostasis, and cross-talk of these elements. While much effort has been made in exploring the ionomic traits relating to plant physiology and nutrition, the use of ionomics in the research of serious diseases is still in progress. In recent years, a number of ionomic studies have been carried out for a variety of complex diseases, which offer theoretical and practical insights into the etiology, early diagnosis, prognosis, and therapy of them. This review aims to give an overview of recent applications of ionomics in the study of complex diseases and discuss the latest advances and future trends in this area. Overall, disease ionomics may provide substantial information for systematic understanding of the properties of the elements and the dynamic network of elements involved in the onset and development of diseases.

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Trace elements in pancreatic cancer

Yanjun,

Jing,

Yifei

et al. 2024

Cancer Medicine

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BackgroundPancreatic cancer (PCA) is an extremely aggressive malignant cancer with an increasing incidence and a low five‐year survival rate. The main reason for this high mortality is that most patients are diagnosed with PCA at an advanced stage, missing early treatment options and opportunities. As important nutrients of the human body, trace elements play an important role in maintaining normal physiological functions. Moreover, trace elements are closely related to many diseases, including PCA.ReviewThis review systematically summarizes the latest research progress on selenium, copper, arsenic, and manganese in PCA, elucidates their application in PCA, and provides a new reference for the prevention, diagnosis and treatment of PCA.ConclusionTrace elements such as selenium, copper, arsenic and manganese are playing an important role in the risk, pathogenesis, diagnosis and treatment of PCA. Meanwhile, they have a certain inhibitory effect on PCA, the mechanism mainly includes: promoting ferroptosis, inducing apoptosis, inhibiting metastasis, and inhibiting excessive proliferation.

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Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma

Cited by 7 publications

References 98 publications

Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias

Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias

Disease Ionomics: Understanding the Role of Ions in Complex Disease

Trace elements in pancreatic cancer

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