Influence of Labour on the Lecithin, Lecithin/ Sphingomyelin (L/S) Ratio and Palmitic Acid Values in the Amniotic Fluid

Cabero, L.; Roses, A. D.; Viscasillas, P.; GlRALT, M. QuilezE.; Durán-Sánchez, P.

doi:10.1111/j.1471-0528.1976.tb00864.x

Cited by 12 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found these values were much higher in those born vaginally than by elective CS. Cabero 11 et al ., in 1976, measured amniotic fluid lecithin/sphingomyelin ratios, and concentrations of lecithin and palmitic acid in a group of mothers before and during labour. At every week of gestation from 34 to 43 weeks, levels were twice as high in those with labour.…”

Section: Discussionmentioning

confidence: 99%

Predicting the need for ventilatory support in neonates 30−36 weeks’ gestational age

Patel

Beeby

2003

J Paediatrics Child Health

View full text Add to dashboard Cite

The risk of needing ventilatory support according to antenatal risk factors is described for infants born between 30 and 36 weeks. Gestational age and absence of labour were found to be the major determinants of risk. Delivery without labour increased the risk by the equivalent of about 2 weeks of gestation. For example, to avoid a risk > 20%, the cut off is 33 weeks for mothers who labour, but is increased to 35 weeks when there is no labour. Our results should be interpreted with caution, as the patients in a tertiary obstetric unit may not be typical of the wider community.

show abstract

Section: Discussionmentioning

confidence: 99%

Predicting the need for ventilatory support in neonates 30−36 weeks’ gestational age

Patel

Beeby

2003

J Paediatrics Child Health

View full text Add to dashboard Cite

show abstract

“…The protective effect of labor is more apparent at 37-38 weeks than at 31-33 weeks (312), presumably because labor stimulates surfactant release and insufficient surfactant is stored at the earlier gestational age. Recent studies have shown that labor increases the L/S ratio and PC content of human amniotic fluid (201,(313)(314)(315). Animal studies have also shown that labor increases surfactant production (70,199).…”

Section: Other Factors Which Influence Surfactant Production In the Fmentioning

confidence: 99%

Lung surfactant.

Rooney¹

1984

Environ Health Perspect

View full text Add to dashboard Cite

Aspects of pulmonary surfactant are reviewed from a biochemical perspective. The major emphasis is on the lipid components of surfactant. Topics reviewed include surfactant composition, cellular and subcellular sites as well as pathways of biosynthesis of phosphatidylcholine, disaturated phosphatidylcholine and phosphatidylglycerol. The surfactant system in the developing fetus and neonate is considered in terms of phospholipid content and composition, rates of precursor incorporation, activities of individual enzymes of phospholipid synthesis and glycogen content and metabolism. The influence of the following hormones and other factors on lung maturation and surfactant production is discussed: glucocorticoids, thyroid hormone, estrogen, prolactin, cyclic AMP, p-adrenergic and cholinergic agonists, prostaglandins and growth factors. The influence of maternal diabetes, fetal sex, stress and labor are also considered. Nonphysiologic and toxic agents which influence surfactant in the fetus, newborn and adult are reviewed.

show abstract

“…Despite these clinical observations, the effect of labor on surfactant production had not been examined. Re-cently, however, two groups (12,13) reported that both the concentration of phosphatidylcholine and the phosphatidylcholine/sphingomyelin ratio in amniotic fluid, indexes of fetal lung maturation (14), were increased during labor in humans.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of Surfactant Production by Oxytocin-Induced Labor in the Rabbit

Rooney¹,

Gobran²,

Wai-Lee³

1977

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T The respiratory distress syndrome is believed to be due to insufficient surfactant. It is known that there is a greater incidence of the respiratory distress syndrome among infants delivered by cesarean section before labor than among those delivered after labor at the same gestational age. The purpose of this study was to determine the effect of labor on the production of pulmonary surfactant.We measured the phospholipid content of lung lavage in newborn rabbits delivered by cesarean section before labor at 29, 30, and 31 (full-term) days gestation and after oxytocin-induced labor at 31 days. We also measured the activities of pulmonary cholinephosphate cytidylyltransferase and cholinephosphotransferase, enzymes involved in the de novo synthesis of phosphatidylcholine, the major component of surfactant.There was a two-to fourfold increase in the amount of lung lavage phospholipid during the first 6 h after birth. This was not dependent upon gestational age at delivery. There was a further two-to fourfold increase in the next 18 h which was, however, dependent upon gestational age. Labor increased the amount of lavage This work was presented, in part, at the 61st Annual

show abstract

Influence of Labour on the Lecithin, Lecithin/ Sphingomyelin (L/S) Ratio and Palmitic Acid Values in the Amniotic Fluid

Cited by 12 publications

References 8 publications

Predicting the need for ventilatory support in neonates 30−36 weeks’ gestational age

Predicting the need for ventilatory support in neonates 30−36 weeks’ gestational age

Lung surfactant.

Stimulation of Surfactant Production by Oxytocin-Induced Labor in the Rabbit

Contact Info

Product

Resources

About