Influence of Lactobacillus Biosurfactants on Skin Permeation of Hydrocortisone

Abruzzo, Angela; Parolin, Carola; Corazza, Elisa; Giordani, Barbara; Cagno, Massimiliano Pio di; Cerchiara, Teresa; Bigucci, Federica; Vitali, Beatrice; Luppi, Barbara

doi:10.3390/pharmaceutics13060820

Cited by 4 publications

(5 citation statements)

References 54 publications

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“…When BC9-BS was solubilized at concentrations from 0.0625 mg/mL to 8.005 mg/mL, a decrease in surface tension from 66 ± 0.5 to 43 ± 1 dyne/cm was observed and the CMC was found to be around 2 mg/mL. Data obtained are in agreement with our previously published results: the presence of electrolytes allows for a greater reduction in surface tension with respect to water, without affecting the CMC value [ 18 ]. Regarding CAPB, it was demonstrated to reduce surface tension from 67.8 ± 0.3 to 34 ± 0 dyne/cm in the concentration range of 0.005–5.275 mg/mL and it exhibited a CMC value of 1.01 mg/mL, which is in line with what has been already reported in literature [ 27 ].…”

Section: Resultssupporting

confidence: 91%

“…Such an increment was even more noticeable when surfactants were used at a concentration five-fold the CMC, reasonably because of amphiphilic molecules tendency to self-assemble in micelles, which are characterized by a hydrophobic region available for the solubilization of HC. BC9-BS, in particular, led to an increase in HC solubility up to 0.300 ± 0.001 mg/mL and 0.357 ± 0.011 mg/mL below and above its CMC respectively, confirming our previous findings: biosurfactants act as solubilizing agents and are able to interact with the drug both as single molecules (i.e., true supersaturation) and micelles [ 18 , 24 ].…”

Section: Resultssupporting

confidence: 86%

“…BC9-BS was demonstrated to be potentially exploited as therapeutic agent to counteract infections caused by methicillin resistant Staphylococcus aureus biofilms [ 17 ], and it was also employed as green excipient in drug formulations. In fact, BC9-BS was used on the one hand to develop mixed vesicles active against chronic vaginal infections [ 14 ] and, on the other hand, as a permeation enhancer in transdermal drug delivery [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Human Lactobacillus Biosurfactants as Natural Excipients for Nasal Drug Delivery of Hydrocortisone

et al. 2022

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The inclusion of a chemical permeation enhancer in a dosage form is considered an effective approach to improve absorption across the nasal mucosa. Herein we evaluated the possibility of exploiting biosurfactants (BS) produced by Lactobacillus gasseri BC9 as innovative natural excipients to improve nasal delivery of hydrocortisone (HC). BC9-BS ability to improve HC solubility and the BS mucoadhesive potential were investigated using the surfactant at a concentration below and above the critical micelle concentration (CMC). In vitro diffusion studies through the biomimetic membrane PermeaPad® and the same synthetic barrier functionalized with a mucin layer were assessed to determine BC9-BS absorption enhancing properties in the absence and presence of the mucus layer. Lastly, the diffusion study was performed across the sheep nasal mucosa using BC9-BS at a concentration below the CMC. Results showed that BC9-BS was able to interact with the main component of the nasal mucosa, and that it allowed for a greater solubilization and also permeation of the drug when it was employed at a low concentration. Overall, it seems that BC9-BS could be a promising alternative to chemical surfactants in the nasal drug delivery field.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Human Lactobacillus Biosurfactants as Natural Excipients for Nasal Drug Delivery of Hydrocortisone

et al. 2022

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“…The integrity of the full-thickness skin was evaluated by measuring the electrical resistance (voltage: 100 mV, frequency: 100 Hz; Agilent 4263B LCR Meter, Microlease, I). Membrane samples with an electrical resistance below 1.57 kΩ/cm 2 were excluded from permeation experiments, in agreement with electrical resistance values recommended in literature [ 71 , 72 ].…”

Section: Methodsmentioning

confidence: 66%

Development and Characterization of Azithromycin-Loaded Microemulsions: A Promising Tool for the Treatment of Bacterial Skin Infections

et al. 2022

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In recent years, the treatment of bacterial skin infections has been considered a major healthcare issue due to the growing emergence of antibiotic-resistant strains of Staphylococcus aureus. The incorporation of antibiotics in appropriate nanosystems could represent a promising strategy, able to overcome several drawbacks of the topical treatment of infections, including poor drug retention within the skin. The present work aims to develop microemulsions containing azithromycin (AZT), a broad-spectrum macrolide antibiotic. Firstly, AZT solubility in various oils, surfactants and co-surfactants was assessed to select the main components. Subsequently, microemulsions composed of vitamin E acetate, Labrasol® and Transcutol® P were prepared and characterized for their pH, viscosity, droplet size, zeta potential and ability to release the drug and to promote its retention inside porcine skin. Antimicrobial activity against S. aureus methicillin-resistant strains (MRSA) and the biocompatibility of microemulsions were evaluated. Microemulsions showed an acceptable pH and were characterized by different droplet sizes and viscosities depending on their composition. Interestingly, they provided a prolonged release of AZT and promoted its accumulation inside the skin. Finally, microemulsions retained AZT efficacy on MRSA and were not cytotoxic. Hence, the developed AZT-loaded microemulsions could be considered as useful nanocarriers for the treatment of antibiotic-resistant infections of the skin.

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“…At concentrations below the CMC, drug permeation through the skin was improved due to the formation of a superficial lipophilic environment and the interaction between BS and the stratum corneum (SC). When skin hydration tests and differential scanning calorimetry (DSC) analyses were carried out to further investigate the BS interaction with the outermost layer of the skin, the data showed that both BS products may be considered as new promising green excipients for drug permeation enhancement through the skin [ 131 ]. Another study by the same research group explored the potential of the L. gasseri BC9 biosurfactant as a natural excipient to enhance the hydrocortisone solubility and nasal delivery and its mucoadhesive properties at concentrations both below and above the CMC.…”

Section: Utilizing Biosurfactants As Adjuvants In Medicine: Drug Deli...mentioning

confidence: 99%

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

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Biosurfactants (BSs) are microbial compounds that have emerged as potential alternatives to chemical surfactants due to their multifunctional properties, sustainability and biodegradability. Owing to their amphipathic nature and distinctive structural arrangement, biosurfactants exhibit a range of physicochemical properties, including excellent surface activity, efficient critical micelle concentration, humectant properties, foaming and cleaning abilities and the capacity to form microemulsions. Furthermore, numerous biosurfactants display additional biological characteristics, such as antibacterial, antifungal and antiviral effects, and antioxidant, anticancer and immunomodulatory activities. Over the past two decades, numerous studies have explored their potential applications, including pharmaceuticals, cosmetics, antimicrobial and antibiofilm agents, wound healing, anticancer treatments, immune system modulators and drug/gene carriers. These applications are particularly important in addressing challenges such as antimicrobial resistance and biofilm formations in clinical, hygiene and therapeutic settings. They can also serve as coating agents for surfaces, enabling antiadhesive, suppression, or eradication strategies. Not least importantly, biosurfactants have shown compatibility with various drug formulations, including nanoparticles, liposomes, micro- and nanoemulsions and hydrogels, improving drug solubility, stability and bioavailability, and enabling a targeted and controlled drug release. These qualities make biosurfactants promising candidates for the development of next-generation antimicrobial, antibiofilm, anticancer, wound-healing, immunomodulating, drug or gene delivery agents, as well as adjuvants to other antibiotics. Analysing the most recent literature, this review aims to update the present understanding, highlight emerging trends, and identify promising directions and advancements in the utilization of biosurfactants within the pharmaceutical and biomedical fields.

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Influence of Lactobacillus Biosurfactants on Skin Permeation of Hydrocortisone

Cited by 4 publications

References 54 publications

Human Lactobacillus Biosurfactants as Natural Excipients for Nasal Drug Delivery of Hydrocortisone

Human Lactobacillus Biosurfactants as Natural Excipients for Nasal Drug Delivery of Hydrocortisone

Development and Characterization of Azithromycin-Loaded Microemulsions: A Promising Tool for the Treatment of Bacterial Skin Infections

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

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