Influence of levamisole on the capacity of neutrophil granulocytes for ingestion and for the reduction of nitrobluetetrazolium

Eschenbach, C; Hahm, Woong; Becker, Daniel F.

doi:10.1007/bf01008658

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…It means that neither the INT reductase activity nor the superoxide generation in normal PMNs during phagocytosis of zymosan particles were influenced by levamisole. ESCHENBACK et al [35] also found that levamisole did not affect NBT reduction by normal PMNs but it was able to stimulate the ingestion of heat-killed staphylococci coated by NBT. Thus it seems that levamisole has probably a different effect on NBT or INT reduction capacity of normal and SLE polymorphs.…”

Section: Discussionmentioning

confidence: 93%

Lysosomal enzymes and metabolic activity of polymorphonuclear leukocytes from patients with systemic lupus erythematosus and from experimental animals after levamisole treatment

1982

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The activity of beta-D-glucuronidase (BDG) was lowered and the activity of myeloperoxidase (MPO) was elevated in polymorphonuclear leukocytes (PMNs) of SLE patients compared with normal subjects. After levamisole treatment, the activities of BDG, MPO, and lysozyme rose in PMNs of SLE patients. A higher activity of lysozyme was also observed in peritoneal PMNs of rabbits after levamisole administration. During incubation of human phagocytizing and non-phagocytizing PMNs, no effects of levamisole at concentrations of 10(-3) to 10(-5) M were observed on the release of lysosomal enzymes. These concentrations of levamisole also did not influence INT reductase activity and production of superoxide by normal human PMNs in the presence of zymosan particles. These findings suggest that levamisole might have an effect on the actual level of lysosomal enzymes in PMNs rather than on their release.

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Section: Discussionmentioning

confidence: 93%

Lysosomal enzymes and metabolic activity of polymorphonuclear leukocytes from patients with systemic lupus erythematosus and from experimental animals after levamisole treatment

1982

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Restoration of defective EAG-rosetting capacity of cancer patient neutrophils by levamisole

Patrone¹,

Dallegri

Pistoia

et al. 1985

Cancer

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Levamisole, used in vitro at therapeutic concentrations, was found able to restore the defective Fc‐receptor activity of cancer patient neutrophils. In addition, the drug prevented the inhibition of normal neutrophils Fc‐receptor function by cancer patient sera. The neutrophil Fc‐receptor function was also restored in six of seven cancer patients after in vivo administration of levamisole (2.5 mg/Kg/day for 3 days). Due to the central role played by the Fc‐receptor function in host defence mechanisms, including phagocytosis as well as antibody dependent cellular cytotoxicity, the capacity of levamisole to restore defective neutrophil Fc‐receptor function in cancer patients could contribute to the “immunomodulating” effect of the drug.

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Disorders of neutrophil function in children with recurrent pyogenic infections

Patrone

Dallegri

Bonvini

et al. 1982

Med Microbiol Immunol

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Ten patients with neutrophil dysfunctions and recurrent pyogenic infections, mainly of the skin middle-ear, and respiratory tract, are described. The most frequently affected functions were chemotaxis and bacterial killing. Pharmacologic restoration of functional defects was tried in all cases. Levamisole was given in two cases and ascorbic acid in the other eight cases. During a follow up of at least 18 months, seven patients showed a complete restoration of neutrophil function and a long-lasting clinical remission. One of the two patients with Chronic Granulomatous Disease has been free from infections for 1 year, despite persistent neutrophil dysfunction, while the other did not display consistent clinical improvement. Another patient, who was given ascorbic acid for a short period only due to non compliance, showed neither laboratory nor clinical improvement.

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Influence of levamisole on the capacity of neutrophil granulocytes for ingestion and for the reduction of nitrobluetetrazolium

Cited by 4 publications

References 11 publications

Lysosomal enzymes and metabolic activity of polymorphonuclear leukocytes from patients with systemic lupus erythematosus and from experimental animals after levamisole treatment

Lysosomal enzymes and metabolic activity of polymorphonuclear leukocytes from patients with systemic lupus erythematosus and from experimental animals after levamisole treatment

Restoration of defective EAG-rosetting capacity of cancer patient neutrophils by levamisole

Disorders of neutrophil function in children with recurrent pyogenic infections

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