Influence of liposphere preparation on butyl-methoxydibenzoylmethane photostability

Iannuccelli, Valentina; Sala, Nicoletta; Tursilli, Rosanna; Coppi, Gilberto; Scalia, Santo

doi:10.1016/j.ejpb.2006.01.007

Cited by 45 publications

(45 citation statements)

References 8 publications

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“…Previous investigations on the improvement of BMDBM photostability by its encapsulation in lipid microparticles have been performed in cream formulations containing BMDBM as the only UV filter (19,26). Although this option provides valuable information on the photochemistry aspects (9), the relevance of these studies to the real conditions of use of sunprotective products is limited, since in a typical sunscreening preparation not just one but a mixture of UVB and UVA filters is always employed in order to provide broad spectrum protection (3,7,9,10).…”

Section: Photodegradation Studiesmentioning

confidence: 99%

“…Previous investigations, demonstrating the photostabilizing effect of LMs on the encapsulated sunscreen agents, have been performed on individual UV filters (19,21,22,26). However, these systems do not simulate the actual conditions of use, since commercial sunscreen products always contain a mixture of UVA and UVB absorbers (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, attention has been focused on lipid microparticles (LMs) as a promising carrier system for sunscreen agents (19,21,22). They consist of a solid lipid core based on naturally occurring lipids and stabilized by a layer of surfactant molecules on the surface (23).…”

Section: Introductionmentioning

confidence: 99%

“…Inclusion complexation with cyclodextrins, encapsulation in micro-and nano-particles have been investigated in order to improve the efficacy and stability of BMDBM under solar radiation (9,14,(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

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Incorporation in Lipid Microparticles of the UVA Filter, Butyl Methoxydibenzoylmethane Combined with the UVB Filter, Octocrylene: Effect on Photostability

Scalia

Mezzena

2009

AAPS PharmSciTech

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Abstract. The aim of this study was to reduce the photoinstability of butyl methoxydibenzoylmethane (BMDBM), the most widely used UVA filter, by incorporating it in lipid microparticles (LMs) alone or together with the UVB filter octocrylene (OCR), acting also as photostabilizer. Microparticles loaded with BMDBM or with combined BMDBM and OCR were produced by the hot emulsion technique, using glyceryl behenate as lipid material and poloxamer 188 as surfactant. The LMs were characterized by release studies, scanning electron microscopy, and powder X-ray diffractometry. The BMDBM and OCR loading was 15.2% and 10.6%, respectively. In order to reproduce the conditions prevalent in commercial sunscreen products, the photoprotective efficacy of the LMs was evaluated after their introduction in a model cream (oil-in-water emulsion) containing a mixture of UVA and UVB filters. A small but statistically significant decrease in BMDBM photodegradation was obtained when the UVA filter was encapsulated alone into the LMs (the extent of degradation was 28.6% ±2.4 for nonencapsulated BMDBM and 26.0% ±2.5 for BMDBM-loaded microparticles). On the other hand, the coloading of OCR in the LMs produced a more marked reduction in the light-induced decomposition of microencapsulated BMDBM (the UVA filter loss was 21.5% ±2.2). Therefore, incorporation in lipid microparticles of BMDBM together with the sunscreen OCR is more effective in enhancing the UVA filter photostability than LMs loaded with BMDBM alone.

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Section: Photodegradation Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incorporation in Lipid Microparticles of the UVA Filter, Butyl Methoxydibenzoylmethane Combined with the UVB Filter, Octocrylene: Effect on Photostability

Scalia

Mezzena

2009

AAPS PharmSciTech

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“…In addition, the research assayed the drug content of microsponges with spectrophotometer at λ max =231 nm [32][33] rather than HPLC.…”

Section: Figure 2 Preparation Of Bpo Microsponges By Quasi-emulsion Smentioning

confidence: 99%

Toward Application of Microsponges in Transdermal Drug Delivery System

Hong¹,

Chen²,

Xiang³

et al. 2015

MOJBB

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Abbreviations: TDDS, transdermal drug delivery system; FDA, food and drug administration; EC, ethyl cellulose; BPO, benzoyl peroxide; SEM, scanning electron microscopy; AUC, area under the curve; EE, entrapment efficiency; DSC, differential scanning calorimetry; MED, minimal erythemal dose; SPF, sun protection factor IntroductionCompared with drug dosage forms for oral and parenteral administration, Transdermal drug delivery system (TDDS) can minimize and avoid some restrictions relating to dosage forms effectively. Due to the conventional delivery systems suffering from certain restrictions like Peak and Valley phenomenon i.e., they show fluctuations in plasma drug concentration and cannot render sustained effect.1 However, the TDDS can meet the requirement to keep relatively stable plasma drug concentration and prolong delivery of drug, in a steady-state profile and minimizes the peak-associated side effects, which thus ensures the level of the drug is effective for treatment on the minimal therapeutic concentration. In general, Transdermal drug delivery system, as a controlled drug delivery system, is exceedingly humanized, commodious and prolong the period of time of release of drug, if need arises (e.g. systemic toxicity) with less pain sensation while administrating drug candidates. Additionally, TDDS permits the permeation of drugs across the skin and into the systemic circulation which avoids the hepatic first-pass effect observed in the course of oral administration and inconvenience of frequent parenteral administration. As a new drug carrier of TDDS, Microsponges are mostly used for topical 4-10 and oral administration. 11-15 For other topical delivery systems, the traditional delivery systems are required of frequent dosing to keep relatively stable local concentrations of effective constituent for therapeutic effectiveness because of low effectiveness.Thus to avoid this defect it is indispensable to design a new drug delivery system to prolong the residual time of drug in the epidermis or the dermis, while reduce its penetration into the body. For this reason, as a porous polymeric microsphere, Microsponges can fulfill such aims uniquely.4 Microsponges are porous, polymeric microspheres (Figure 1) which are invariably used for topical delivery system; 4-5,7-10 its inside are full of lacunas and its particle size is 5~300μm in diameter. AbstractTransdermal drug delivery system (TDDS) is a dosage form designed to deliver drug through skin by topical route of administration to the systemic circulation or for local treatment. As a new type of dosage form, TDDS has a number of special merits, but inevitably at the same time it possess some distinct disadvantages, such as low permeability and the drug mostly enter the systemic vascular. Microsponges are a kind of micro-sized and polyporous particles which can entrap effective constituents, and are biologically safe. And Microsponges also exhibit distinctive advantage at the aspect of drug release. The TDDS can enhance drug stability, decrease side effec...

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Carbon Nanofiber in Cosmetics

Singh

2021

Carbon Nanofibers

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Influence of liposphere preparation on butyl-methoxydibenzoylmethane photostability

Cited by 45 publications

References 8 publications

Incorporation in Lipid Microparticles of the UVA Filter, Butyl Methoxydibenzoylmethane Combined with the UVB Filter, Octocrylene: Effect on Photostability

Incorporation in Lipid Microparticles of the UVA Filter, Butyl Methoxydibenzoylmethane Combined with the UVB Filter, Octocrylene: Effect on Photostability

Toward Application of Microsponges in Transdermal Drug Delivery System

Carbon Nanofiber in Cosmetics

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