The fluid flow around a yawed cylinder helps to understand the practical implications for undersea applications, such as managing transference, separating the boundary layer above submerged blocks, and suppressing recirculating bubbles. As many authors such as Roy, Chiu and Lienhard, Roy and Saikrishnan, and Revathi et al. have analyzed a boundary layer flow over a yawed cylinder, and their work sticks to only forced convection, we are interested to work on mixed convection flow. Therefore, the work of these researchers has stimulated us to work on the present article. As a result, we have examined the work on triple diffusion quadratic mixed convective nanofluid flow over a moving yawed cylinder. The impact of yaw angle, which exists due to the inclination of a vertically moving cylinder away from the origin, is mathematically investigated in the present paper by converting the governing equations into a compatible form using appropriate nonsimilar transformations and the quasilinearization technique. Nanofluids have crucial usages in science and technology, marine engineering, and applications in industries such as plastic, polymer industries, cancer home therapy, and building sciences. Many processes in new engineering areas occur at high temperatures, and knowledge of radiation heat transfer becomes very important for designing the pertinent equipment. Nuclear power plants, gas turbines, and the various propulsion devices for aircraft, missiles, satellites, and space vehicles are examples of such engineering areas. The finite difference approximation is employed to solve the resulting equations. Enhancing the magnitude of thermal radiation enhances the temperature of the liquid and the energy transport strength. However, liquid hydrogen and liquid oxygen species concentration patterns are reduced in nanofluid compared to traditional liquids. At the same time, the outcomes behave conversely in the case of their wall gradients. Furthermore, the temperature of the liquid enhances the enhancing values of Brownian motion and thermophoresis characteristics. Moreover, nanoparticle mass transport augments with enhancing yaw angle and Lewis number values. Both species' concentration profiles decrease for increasing values of yaw angle. The velocity profiles increase for increasing values of velocity ratio parameter in the spanwise and chordwise directions.