“…The significant decreases in submaximal _ V O 2 observed by Sutton and colleagues (1988) during their simulated ascent of Mount Everest are consistent with the 10 -20% decreases for altitude natives compared with lowlanders. Several careful investigations in the past 6 years have also found a 3 -5% decrease in submaximal _ V O 2 after a few weeks spent either in natural (Green et al, 2000;MacDonald, Green, Naylor, Otto, & Hughson, 2001;Schmitt et al, 2006) or simulated hypoxia (Gore et al, 2001;Katayama, Matsuo, Ishida, Mori, & Miyamura, 2003;Katayama et al, 2004;Neya, Enoki, Kumai, Sugoh, & Kawahara, 2007;Saunders et al, 2004), but many researchers in the contemporary and classical altitude literature have found no significant changes in submaximal _ V O 2 (Consolazio, Nelson, Matoush, & Hansen, 1966;Klausen, Dill, & Horbath, 1970;Levine & Stray-Gundersen, 1997;Lundby et al, 2007).…”