Influence of magnetic field on zebrafish activity and orientation in a plus maze

Osipova, Elena A.; Павлова, В. В.; Nepomnyashchikh, V. A.; Крылов, В. В.

doi:10.1016/j.beproc.2015.11.009

Cited by 27 publications

(14 citation statements)

References 32 publications

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“…Thus, NMR seems to specifically target the clock genes cry1aa and per1b in zebrafish cells and whole animals. Cry1 protein was repeatedly reported to be responsible for the light-dependent magnetosensitivity of animals which are able to perceive the MF of the earth, among them also the zebrafish (Takebe et al 2012;Osipova et al 2016). Only recently, a light-independent magnetoreception was found in zebrafish and medaka (Myklatun et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Nuclear magnetic resonance affects the circadian clock and hypoxia-inducible factor isoforms in zebrafish

Oliva

Jansen

Benscheidt

et al. 2018

Biological Rhythm Research

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Nuclear magnetic resonance (NMR) is used for magnetic resonance imaging and, at a lower intensity, as therapy for the treatment of musculoskeletal disorders. Due to the involvement of the circadian clock protein CRYPTOCHROME in the magnetic orientation of animals, it was repeatedly assumed that magnetic fields might affect the circadian rhythm of cells and organisms. Since circadian time keeping and hypoxic signaling are mutually intertwined, we investigated the effects of NMR on both cellular pathways in zebrafish fibroblast cells and larvae. In cells, basal mRNA expression of cryptochrome1aa was increased and oscillations of crypto-chrome1aa and period1b were shifted in phase, while those of clock1a and period2 remained unaffected. Similarly, circadian oscillations of cryptochrome1aa and period1b were restored in zebrafish larvae, while those of clock1a and period2 remained unaltered. NMR also restored the circadian expression of the hypoxia-inducible factor (Hif) isoforms Hif-1α and Hif-3α at the mRNA and protein level, but had no effect on the expression of Hif-2α. Thus, NMRmediated effects might differ substantially from the light-induced reset of the circadian clock in the same species and therefore represent an additional operation mode of the cellular clock, enabling distinct processing of photic and magnetic information.

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Section: Discussionmentioning

confidence: 99%

Nuclear magnetic resonance affects the circadian clock and hypoxia-inducible factor isoforms in zebrafish

Oliva

Jansen

Benscheidt

et al. 2018

Biological Rhythm Research

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“…We particularly encourage experimental tests on model organisms (e.g., zebrafish, Danio rerio; honey bees, Apis mellifera; eels, Anguilla spp.) that are sensitive to both magnetic (Kirschvink, 1981;Tesch et al, 1992;Osipova et al, 2016) and gravitational cues (Korall and Martin, 1987;Moorman and Shorr, 2008;Cresci et al, 2017). Integrated analysis of telemetry datasets will further help identify the ways in which geophysical cues are used for navigational purposes.…”

Section: Geophysical Navigationmentioning

confidence: 99%

Route Fidelity during Marine Megafauna Migration

Horton

Hauser²,

Zerbini

et al. 2017

Front. Mar. Sci.

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The conservation and protection of marine megafauna require robust knowledge of where and when animals are located. Yet, our ability to predict animal distributions in space and time remains limited due to difficulties associated with studying elusive animals with large home ranges. The widespread deployment of satellite telemetry technology creates unprecedented opportunities to remotely monitor animal movements and to analyse the spatial and temporal trajectories of these movements from a variety of geophysical perspectives. Reproducible patterns in movement trajectories can help elucidate the potential mechanisms by which marine megafauna navigate across vast expanses of open-ocean. Here, we present an empirical analysis of humpback whale (Megaptera novaeangliae), great white shark (Carcharodon carcharias), and northern elephant seal (Mirounga angustirostris) satellite telemetry-derived route fidelity movements in magnetic and gravitational coordinates. Our analyses demonstrate that: (1) humpback whales, great white sharks and northern elephant seals are capable of performing route fidelity movements across millions of square kilometers of open ocean with a spatial accuracy of better than 150 km despite temporal separations as long as 7 years between individual movements; (2) route fidelity movements include significant (p < 0.05) periodicities that are comparable in duration to the lunar cycles and semi-cycles; (3) latitude and bedrock-dependent gravitational cues are stronger predictors of route fidelity movements than spherical magnetic coordinate cues when analyzed with respect to the temporally dependent moon illumination cycle. We further show that both route fidelity and non-route fidelity movement trajectories, for all three species, describe overlapping in-phase or antiphase sinusoids when individual movements are normalized to the gravitational acceleration present at migratory departure sites. Although these empirical results provide an inductive basis for the development of testable hypotheses and future research questions, they cannot be taken as evidence for causal relations between marine megafauna movement decisions and geophysical cues. Experiments Horton et al.Marine Megafauna Route Fidelity on model organisms with known sensitivities to gravity and magnetism, complemented by further empirical observation of free-ranging animals, are required to fully explore how animals use discrete, or potentially integrated, geophysical cues for orientation and navigation purposes.

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“…This experimental design ensured that the current running through the coils was the same (but of opposite direction in the E−W coil pair) in both conditions. In distinction to previous studies in zebrafish 46 – 48 , the behavioral response could thus be confidently assigned to the change of the direction of the MF. In addition, we tested fish in presence or absence of short-wavelength light (Fig.…”

Section: Resultsmentioning

confidence: 88%

“…Recent reports have suggested that zebrafish are magnetoreceptive 45 – 48 , but no knowledge regarding the mechanism or the neuronal circuits is yet available. In this work, we sought to conduct a comparative study in two teleost models, to test (i) whether light-independent magnetoreception is present, and (ii) whether a behavioral assay could be established in young fish that is compatible with neuronal activity mapping across the whole-brain (Fig.…”

Section: Introductionmentioning

confidence: 99%

Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception

et al. 2018

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An impediment to a mechanistic understanding of how some species sense the geomagnetic field (“magnetoreception”) is the lack of vertebrate genetic models that exhibit well-characterized magnetoreceptive behavior and are amenable to whole-brain analysis. We investigated the genetic model organisms zebrafish and medaka, whose young stages are transparent and optically accessible. In an unfamiliar environment, adult fish orient according to the directional change of a magnetic field even in darkness. To enable experiments also in juveniles, we applied slowly oscillating magnetic fields, aimed at generating conflicting sensory inputs during exploratory behavior. Medaka (but not zebrafish) increase their locomotor activity in this assay. Complementary brain activity mapping reveals neuronal activation in the lateral hindbrain during magnetic stimulation. These comparative data support magnetoreception in teleosts, provide evidence for a light-independent mechanism, and demonstrate the usefulness of zebrafish and medaka as genetic vertebrate models for studying the biophysical and neuronal mechanisms underlying magnetoreception.

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Influence of magnetic field on zebrafish activity and orientation in a plus maze

Cited by 27 publications

References 32 publications

Nuclear magnetic resonance affects the circadian clock and hypoxia-inducible factor isoforms in zebrafish

Nuclear magnetic resonance affects the circadian clock and hypoxia-inducible factor isoforms in zebrafish

Route Fidelity during Marine Megafauna Migration

Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception

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