Influence of magnitude of weight loss on Adipo/lep ratio in adolescents with obesity undergoing multicomponent therapy

Ferreira, Yasmin Alaby Martins; Kravchychyn, Ana Claudia Pelissari; Vicente, Sofia de Castro Ferreira; Campos, Raquel Munhoz da Silveira; Tock, Lian; Oyama, Lila Missae; Boldarine, Valter Tadeu; Masquio, Deborah Cristina Landi; Dâmaso, Ana Raimunda

doi:10.1016/j.cyto.2020.155111

Cited by 10 publications

(4 citation statements)

References 49 publications

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“…Another successful investigation, developed with overweight or obese individuals, was based on daily self-monitoring of diet and/or body weight, suggesting that this kind of intervention could serve as an effective strategy for weight loss (54). Previous studies by our group with obese adolescents found that semi-intensive therapy was effective to improve body composition, HDL-cholesterol, leptin concentration and nutritional profile, suggesting that this kind of intervention can be used to treat obesity (46,55).…”

Section: Discussionmentioning

confidence: 99%

Effects of an interdisciplinary weight loss program on fibroblast growth factor 21 and inflammatory biomarkers in women with overweight and obesity

Dâmaso¹,

Machado²,

Rhein³

et al. 2021

Archives of Endocrinology and Metabolism

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Objective: To investigate the effects of an interdisciplinary intervention on biomarkers of inflammation and their relationship with fibroblast growth factor 21 (FGF21) concentrations in women with overweight and obesity. Subjects and methods: Thirty-one women were enrolled in a 12-week interdisciplinary weight loss program delivered by a team comprising an endocrinologist, nutritionist and exercise physiologist. Body composition; anthropometric measures; metabolic and inflammatory markers including adiponectin, leptin, and atrial natriuretic peptide (ANP) were assessed at baseline and post-therapy. The homeostasis model assessment of insulin resistance (HOMA-IR) and the homeostasis model assessment of adiponectin (HOMA-AD) were calculated. The participants were divided into two groups: those with increased FGF21, and those with decreased FGF21. Results: The sample comprised women aged 32 ± 5 years with a body mass index of 33.64 ± 3.49 kg/m². Body weight, waist circumference and leptin concentration were decreased in the whole sample after therapy. However, only the group with an increase in FGF21 concentration presented significant improvements in adiponectin concentration and adiponectin/leptin ratio. Moreover, although there was a reduction of leptin in both groups, it was greater in the increased FGF21 groups. There was a reduction in ANP in the decreased FGF21 group. Conclusions: Changes in FGF21 concentrations were different among the women participating in the weight loss program, with some having increased levels and some reduced levels. Furthermore, improvements in adiponectin and the adiponectin/ leptin ratio were found only in the group with increased FGF21 concentration.

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Section: Discussionmentioning

confidence: 99%

Effects of an interdisciplinary weight loss program on fibroblast growth factor 21 and inflammatory biomarkers in women with overweight and obesity

Dâmaso¹,

Machado²,

Rhein³

et al. 2021

Archives of Endocrinology and Metabolism

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“…The L:A ratio has been demonstrated to improve after a weight loss of 5-10% by Ferreira et al and Talaei et al, among others. (33,34).…”

Section: Discussionmentioning

confidence: 99%

Modest weight loss improves leptin to adiponectin ratio and induces insulin and leptin resensitivization in individuals with obesity.

Isaksen¹,

Larsen

Goll

et al. 2021

Preprint

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Background Weight loss is important to reduce the risk of metabolic complications in obese individuals, in whom dysregulated adipokines play a central role. This study aims to investigate whether dysregulated adipokines and postprandial triglycerides (TG) improve with a modest weight loss. Methods Individuals with obesity were recruited among patients at the University Hospital of North Norway and the Stamina Health weight loss rehabilitation program. We measured resting energy expenditure (REE), and calculated the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), leptin to adiponectin (L:A) ratio, indirect leptin sensitivity (REE:leptin ratio), postprandial TG clearance at 6 h, and TG response before and after weight loss. The goal of the weight loss intervention was a loss of ≥5% of initial total body weight. Results Of the 28 participants who attended two scheduled assessments, 13 lost ≥5% body weight. HOMA-IR (-23.1%), REE:leptin ratio (+80.1%) and L:A ratio (-45.7%) significantly improved with weight loss, whereas there was no improvement of postprandial TG response or clearance. No significant changes were observed in the non-weight loss group. Conclusion Metabolic dysregulation, as insulin and leptin resistance, but not postprandial TG improve with a modest weight loss in individuals with obesity.

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“…This ratio is inversely correlated with adipose tissue dysfunction, characterized by subclinical inflammatory state, insulin resistance and a high risk for metabolic syndrome [67,68]. Improving this parameter could be a valuable way to control obesity-associated cardiometabolic alterations [69].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of a Discontinuous Treatment with Alpha-Lipoic Acid in Obesity-Related Heart Failure with Preserved Ejection Fraction, in Rats

et al. 2020

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Obesity induces hemodynamic and humoral changes that are associated with functional and structural cardiac remodeling, which ultimately result in the development of heart failure (HF) with preserved ejection fraction (HFpEF). In recent years, pharmacological studies in patients with HFpEF were mostly unsatisfactory. In these conditions, alternative new therapeutic approaches are necessary. The aim of our study was (1) to assess the effects of obesity on heart function in an experimental model and (2) to evaluate the efficacy of an alpha-lipoic acid (ALA) antioxidant treatment. Sprague-Dawley rats (7 weeks old) were either included in the control group (n = 6) or subjected to abdominal aortic banding (AAB) and divided into three subgroups, depending on their diet: standard (AAB + SD, n = 8), hypecaloric (AAB + HD, n = 8) and hypercaloric with discontinuous ALA treatment (AAB + HD + ALA, n = 9). Body weight (BW), glycemia, echocardiography parameters and plasma hydroperoxides were monitored throughout the study. After 36 weeks, plasma adiposity (leptin and adiponectin) and inflammation (IL-6 and TNF-alpha) markers, together with B-type natriuretic peptide and oxidative stress markers (end-products of lipid peroxidation and endogenous antioxidant systems) were assessed. Moreover, cardiac fiber diameters were measured. In our experiment, diet-induced obesity generated cardiometabolic disturbances, and in association with pressure-overload induced by AAB, it precipitated the onset of heart failure, cardiac hypertrophy and diastolic dysfunction, while producing a pro-oxidant and pro-inflammatory plasmatic status. In relationship with its antioxidant effects, the chronic ALA-discontinuous treatment prevented BW gain and decreased metabolic and cardiac perturbations, confirming its protective effects on the cardiovascular system.

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Influence of magnitude of weight loss on Adipo/lep ratio in adolescents with obesity undergoing multicomponent therapy

Cited by 10 publications

References 49 publications

Effects of an interdisciplinary weight loss program on fibroblast growth factor 21 and inflammatory biomarkers in women with overweight and obesity

Effects of an interdisciplinary weight loss program on fibroblast growth factor 21 and inflammatory biomarkers in women with overweight and obesity

Modest weight loss improves leptin to adiponectin ratio and induces insulin and leptin resensitivization in individuals with obesity.

Protective Effects of a Discontinuous Treatment with Alpha-Lipoic Acid in Obesity-Related Heart Failure with Preserved Ejection Fraction, in Rats

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