Influence of Magnolol on the bystander effect induced by alpha-particle irradiation

Wong, T. P.W.; Law, Y.L.; Tse, Anfernee Kai-Wing; Fong, Wang‐Fun; Yu, K.N.

doi:10.1016/j.apradiso.2009.09.034

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…It is an indirect effect of ionizing radiation which causes damages to non-irradiated cells. Bystander effect results from the release of clastogenic factors from damaged cells, which can change gene expression and trigger overproduction of endogenous free radicals [60]. For the first time, Nagasawa showed that irradiation with protons causes sister chromatid exchanges in Chinese hamster ovary (CHO) cells [61].…”

Section: Evidence On Carcinogenic Effects Of Heavy Charged Particlesmentioning

confidence: 99%

Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications

et al. 2019

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One of the uses of ionizing radiation is in cancer treatment. The use of heavy charged particles for treatment has been introduced in recent decades because of their priority for deposition of radiation energy in the tumor, via the Bragg peak phenomenon. In addition to medical implications, exposure to heavy charged particles is a crucial issue for environmental and space radiobiology. Ionizing radiation is one of the most powerful clastogenic and carcinogenic agents. Studies have shown that although both low and high linear energy transfer (LET) radiations are carcinogenic, their risks are different. Molecular studies have also shown that although heavy charged particles mainly induce DNA damage directly, they may be more potent inducer of endogenous generation of free radicals compared to the low LET gamma or X-rays. It seems that the severity of genotoxicity for non-irradiated bystander cells is potentiated as the quality of radiation increases. However, this is not true in all situations. Evidence suggests the involvement of some mechanisms such as upregulation of pro-oxidant enzymes and change in the methylation of DNA in the development of genomic instability and carcinogenesis. This review aimed to report important issues for genotoxicity of carcinogenic effects of heavy charged particles. Furthermore, we tried to explain some mechanisms that may be involved in cancer development following exposure to heavy charged particles.

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Section: Evidence On Carcinogenic Effects Of Heavy Charged Particlesmentioning

confidence: 99%

Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications

et al. 2019

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“…a-particle radiation exposure has been shown to result in a variety of genetic lesions, including chromosomal damage (Kennedy et al, 1996), gene mutations (Hei et al, 1988), induction of micronuclei (Bilbao et al, 1989), sister chromatic exchanges (Nagasawa and Little, 1992), bystander mutagenic effects (Li et al, 2010), and DNA double-strand break (Hu et al, 2005a). To date, studies of a-particle radiation have been performed primarily using animal tissues and cells (Belyakov et al, 2003;Wong et al, 2010). Accordingly, plant physiological and morphological responses induced by a-particle radiation are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Physiological and morphological responses induced by α-particle radiation on Arabidopsis thaliana embryos

Ren¹,

Liu²,

Jin³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Alpha (a)-particle radiation has been thoroughly studied in the occupational and residential environments, but biological mechanisms induced by a-particle radiation on plants are not clearly understood. In this study, radiation effects were examined using different total doses (1, 10, 100 Gy, respectively) of 241 Am, a-particle on Arabidopsis embryos. No significant difference in the germination percentage was observed between the 3 levels of doses and the control. Germination speed and root length were increased by treatment with the 1-Gy dose of a-particles, and decreased by treatment with 10-and 100-Gy doses. Moreover, the bending degree of roots increased with radiation dose, and the roots showed an "S" shape when treated with the 100-Gy dose. Root bending under the 100-Gy dose was inhibited by scavengers of reactive oxygen species (ROS). Root gravitropism and root length may respond to the consistency of ROS induced by irradiation. Further analysis of the physiological effects revealed that an increase in a-particle radiation intensity enhanced the activity of catalase and the content of malondialdehyde, but superoxide dismutase activity was reduced by treatment with 100-Gy radiation of a-particles, suggesting that the high linear energy transfer of a-particles may cause a relatively high level of membrane lipid preoxidation and high accumulation of ROS. ROS showed both physiological and morphological responses following exposure to a-particle radiation in Arabidopsis embryos.

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Influence of catechins on bystander responses in CHO cells induced by alpha-particle irradiation

Law

Wong

2010

Applied Radiation and Isotopes

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Influence of Magnolol on the bystander effect induced by alpha-particle irradiation

Cited by 5 publications

References 23 publications

Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications

Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications

Physiological and morphological responses induced by α-particle radiation on Arabidopsis thaliana embryos

Influence of catechins on bystander responses in CHO cells induced by alpha-particle irradiation

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