This paper presents a comparison of optimizers for tuning a fractional-order proportional-integral-derivative (FOPID) and proportional-integral-derivative (PID) controllers, which were applied to a DC/DC boost converter. Grey wolf optimizer (GWO) and extended grey wolf optimizer (EGWO) have been chosen to achieve suitable parameters. This strategy aims to improve and optimize a proton exchange membrane fuel cell (PEMFC) output power quality through its link with the boost converter. The model and controllers have been implemented in a MATLAB/SIMULINK environment. This study has been conducted to compare the effectiveness of the proposed controllers in the transient, accuracy in tracking the reference current, steady-state, dynamic responses, overshoots, and response time. Results showed that the combination EGWO-FOPID had significant advantages over the rest of the optimized controllers.