Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study

Hazarika, Archana; Sarkar, Srobana; Hajare, SW; Kataria, Meena; Malik, Jitendra K.

doi:10.1016/s0300-483x(02)00574-7

Cited by 191 publications

(130 citation statements)

References 32 publications

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“…The results of our study were consistent with other studies suggesting that pesticides increase oxidative stress in humans (Prakasam et al 2001;Singh et al, 2007). There is increasing evidence that OP and carbamate induced oxidative stress through the generation of free oxygen radicals, leading to lipid peroxidation and DNA damage (Hazarika et al, 2003;Abdollahi et al, 2004;Vidyasagar et al, 2004;Shadnia et al, 2005). Muniz and co workers reported MDA levels 4.9 times and 24 times higher in farm workers and applicators respectively than in controls (Muniz et al, 2007).…”

Section: Oxidative Stresssupporting

confidence: 82%

Adverse Health Effects of Pesticides Exposure in Agricultural and Industrial Workers of Developing Country

Hashmi¹,

Imran²,

Dilshad³

2011

Pesticides - The Impacts of Pesticides Exposure

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Section: Oxidative Stresssupporting

confidence: 82%

Adverse Health Effects of Pesticides Exposure in Agricultural and Industrial Workers of Developing Country

Hashmi¹,

Imran²,

Dilshad³

2011

Pesticides - The Impacts of Pesticides Exposure

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“…Our results concerning to the clinical signs on the treated groups that showed apparently normal signs except in malathion group which showed some cases of diarrhea may be due to pesticides caused enteritis, there were some cases showed lameness in the second week may be due to organophosphorous pesticides are known to induce toxicity in mammals by inhibiting acetyl cholinesterase which leads to accumulation of acetylcholine and the subsequent activation of cholinergic, muscarinic and nicotinic receptors (Hazarika et al, 2003) or may be due to weakness as a result of diarrhea and there were no mortalities may be due to low doses. The similar results were obtained by Veerramachaneni et al, (2006).…”

Section: Discussionmentioning

confidence: 98%

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Elzoghby¹,

Hamoda²,

Aboubakr³

et al. 2014

American Journal of Pharmacology and Toxicology

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The present study was designed to determine the modulating effect of green tea and vitamin C against adverse effects of malathion. Animals were divided into four groups 5 rats /group). Group one was used as a control. Group two given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks). Group three and Group four were given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks) plus vitamin C (200 mg/kg/day) and plus green tea (36 mg/kg/day) respectively. At the end of the fourth week, the malathion-treated group had significantly lower Red Blood Cell count (RBCs), Hemoglobin concentration (Hb), Packed Cell Volume (PCV%) and leucocytes (WBCs) than the control group. Compared to the control group, the malathion-treated group had significantly higher serum Alkaline Phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), urea, creatinine and uric acid levels than the control group. The malathion treated rats also had significantly lower serum total protein, albumin and globulin levels than the control group, but the malathion plus vitamin C and malathion plus green tea groups did not differ from the control group in terms of these parameters. Moreover, concomitant vitamin C and green tea treatment significantly normalized, at least partially, all of the other hematological and biochemical parameters that were altered by malathion. Liver tissue homogenate in malathion treated group had lower Glutathione (GSH), Glutathione Peroxidase (GSH-PX) and Superoxide Dismutase (SOD) levels accompanied with higher level of Malondialdehyde (MDA) than the control group. Histopathological studies revealed that the malathion-treated, malathion plus vitamin C and malathion plus green tea treated groups exhibited histopathological changes in liver and kidney tissues, although some pathological features were only observed in the malathion-treated group. Thus, vitamin C and green tea can reduce malathion hepatotoxicity and nephrptoxicity.

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“…Organophosphate pesticides (OP) are primarily recongnized for their ability to induce toxicity in mammals through inhibition of acethylcholinesterase (AChE) [1]. Also, it has been demonstrated that lipid peroxidation mediated by free radicals is one of the molecular mechanisms involved in OP-induced toxicity [2,3] and several pesticides exert their biological effects through electrophilic attack on the cellular constituents of hepatic and brain tissues [4] with simultaneous generation of reactive oxygen species [5].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats

Heikal¹

2012

J Environ Anal Toxicol

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Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study

Cited by 191 publications

References 32 publications

Adverse Health Effects of Pesticides Exposure in Agricultural and Industrial Workers of Developing Country

Adverse Health Effects of Pesticides Exposure in Agricultural and Industrial Workers of Developing Country

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats

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