Influence of male hyperinsulinaemia on IVF outcome

Bosman, E.; Esterhuizen, A. D.; Rodrigues, F. A.; Becker, Piet J.; Hoffmann, Willem A.

doi:10.1111/and.12227

Cited by 3 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study, it was reported previously that hyperinsulinaemic male patients had a significantly lower IVF pregnancy rate of 31.8% when compared to the 57.9% pregnancy rate, of a normo‐insulinaemic male group (Bosman et al ., ). Early diagnosis and treatment of male hyperinsulinaemia prior to ART is advised as improved morphology and CMA 3 values can be beneficial to pregnancy outcome.…”

Section: Discussionmentioning

confidence: 97%

“…Insulin has an influence on the levels of sex‐hormone‐binding globulin (SHBG) and can contribute to low testosterone levels (Jensen et al ., ; Tsai et al ., ). Men with high insulin levels have a tendency to present with a higher percentage of poorly compacted sperm deoxyribonucleic acid (DNA) and lower pregnancy rates in an IVF programme (Bosman et al ., , ). Certain treatments such as metformin, a modified diet and exercise, can effectively control high insulin levels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males

Bosman¹,

Esterhuizen²,

Rodrigues³

et al. 2014

Andrologia

Self Cite

View full text Add to dashboard Cite

SummaryPrevious reports indicated that hyperinsulinaemic men may exhibit a higher percentage of poorly compacted DNA in their spermatozoa and less success in an IVF programme (Andrologia, 45, 2003, 18; Andrologia, 2014 Andrologia, , doi: 10.1111. The aim of this study was to investigate the effect of metformin (Glucophage ® ) and antioxidant treatment (StaminoGro ® ) on the semen parameters of hyperinsulinaemic men. Nineteen hyperinsulinaemic male patients were treated for 3 months with metformin alone (Group A), and fifteen patients used metformin in combination with the nutritional supplement (Group B). Combined data of the two groups (pre-and post-treatment) differ significantly regarding sperm morphology (P = 0.0003) and CMA 3 (P < 0.0001) values. The improvement in sperm morphology after treatment was similar for the two respective groups (P < 0.05). The morphological normal sperm forms increased from the mean percentage of 3.9 to 5.5% and from 4.2 to 5.5% for Group A and B respectively. Where a combination of metformin and the supplement were used (Group B), the combination treatment proved to be superior in obtaining enhanced chromatin packaging quality although not statistically significant (P = 0.5929) when compared with the metformin (Group A) group. The chromatin packaging quality in Group B improved with 10% while the improvement in Group A was approximately 8.3%. Therefore, infertile hyperinsulinaemic men can benefit from metformin treatment and should be advised on the use of nutritional supplements with antioxidant properties.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males

Bosman¹,

Esterhuizen²,

Rodrigues³

et al. 2014

Andrologia

Self Cite

View full text Add to dashboard Cite

show abstract

“…Three oocytes per GIFT. Mean number of cycles per pregnancy 7.3 (IUI) vs 2.0 (GIFT).Bosman et al (2015)Propsective observational study comparing ART outcome in couples with hyperinsulinaemic and normoinsulinaemic men (all normozoospermic).Higher CPR/ET in normoinsulinaemic versus hyperinsulinaemic group (57.9% vs 31.8%).Dyer and Kruger (2012)Registry data.4512 aspirations for IVF,ICSI and OD. CPR/asp 28.9%; 12.8% SETs b and 54.5% DETs b .…”

Section: Resultsmentioning

confidence: 99%

“…The majority documented a rate ≥20% although the range was wide (12.5–44.4%). The rate of triplet pregnancies ranged from 4.0% to 14.5% (Noreh et al , 2009; Adesiyun, 2011; Oloyede et al , 2012; Orhue et al , 2012; Bosman et al , 2015); that of miscarriages from 11.8% to 22.2% per clinical pregnancy (Abels et al , 2007; Ezechi et al , 2008; Noreh et al , 2009; Okohue et al , 2013; Orhue et al , 2012); and that of ectopic pregnancies from 2.2% to 4.2% per clinical pregnancy (Abels et al , 2007; Noreh et al , 2009; Okohue et al , 2009; Orhue et al , 2012). The frequency of ovarian hyperstimulation syndrome ranged widely, from 0.3% per initiated cycle to 18.2% per woman with polycystic ovary syndrome, without severity being specified (Noreh et al , 2009; Orhue et al , 2012; Okohue et al , 2013).…”

Section: Safetymentioning

confidence: 99%

Availability, effectiveness and safety of ART in sub-Saharan Africa: a systematic review

Botha

Shamley

Dyer

2018

Human Reproduction Open

View full text Add to dashboard Cite

STUDY QUESTION What is the evidence pertaining to availability, effectiveness and safety of ART in sub-Saharan Africa? SUMMARY ANSWER According to overall limited and heterogeneous evidence, availability and utilization of ART are very low, clinical pregnancy rates largely compare to other regions but are accompanied by high multiple pregnancy rates, and in the near absence of data on deliveries and live births the true degree of effectiveness and safety remains to be established. WHAT IS KNOWN ALREADY In most world regions, availability, utilization and outcomes of ART are monitored and reported by national and regional ART registries. In sub-Saharan Africa there is only one national and no regional registry to date, raising the question what other evidence exists documenting the status of ART in this region. STUDY DESIGN, SIZE, DURATION A systematic review was conducted searching Pubmed, Scopus, Africawide, Web Of Science and CINAHL databases from January 2000 to June 2017. A total of 29 studies were included in the review. The extracted data were not suitable for meta-analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS The review was conducted according to Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. All peer-reviewed manuscripts irrespective of language or study design that presented original data pertaining to availability, effectiveness and safety of ART in sub-Saharan Africa were eligible for inclusion. Selection criteria were specified prior to the search. Two authors independently reviewed studies for possible inclusion and critically appraised selected manuscripts. Data were analysed descriptively, being unsuitable for statistical analysis. MAIN RESULTS AND THE ROLE OF CHANCE The search yielded 810 references of which 29 were included based on the predefined selection and eligibility criteria. Extracted data came from 23 single centre observational studies, two global ART reports, two reviews, one national data registry and one community-based study. ART services were available in 10 countries and delivered by 80 centres in six of these. Data pertaining to number of procedures existed from three countries totalling 4619 fresh non-donor aspirations in 2010. The most prominent barrier to access was cost. Clinical pregnancy rates ranged between 21.2% and 43.9% per embryo transfer but information on deliveries and live births were lacking, seriously limiting evaluation of ART effectiveness. When documented, the rate of multiple pregnancy was high with information on outcomes similarly lacking. LIMITATIONS, REASONS FOR CAUTION The findings in this review are based on limited data from a limited number of countries, and are derived from heterogeneous studies, both in terms of study design and quality, many of which include small sample sizes. Although representing best available e...

show abstract

“…The role of FH on male reproduction is further confirmed in men with diabetes, where fluctuations in insulin and glucose concentrations alter spermatogenesis and male reproductive function on multiple levels, including impaired penile erection, ejaculation, metabolic disturbances in testicular cells, a reduction in total sperm count, impaired sperm motility and sperm morphology [ 9 – 11 ]. A clinical study also showed that hyperinsulinemia in fathers presented poorer embryo quality and lower singleton and twin pregnancy rates [ 4 ]. Although the effect of FH on male reproductive function is gradually being noticed [ 11 – 13 ], the relationship between paternal FH and the pregnancy outcome of ART is not well described according to the current studies.…”

Section: Introductionmentioning

confidence: 99%

Effects of fasting hyperglycemia in men on pregnancy outcomes of singleton pregnant women with cryo-thawed embryo transfer

Yang,

Tian,

et al. 2023

Eur J Med Res

View full text Add to dashboard Cite

Background The relationship of metabolic issues to pregnancy outcomes during assisted reproductive technology (ART) is gaining much attention. Fasting Plasma Glucose (FPG) is one of the most common metabolic indicators. Abnormal FPG not only affects the quality of life of human body, but also has a bearing on reproductive health. However, most attentions are paid on women's physical health and reproductive assessment, the health status of the male partner on pregnancy outcomes during ART treatment is often neglected. This study investigated whether male fasting hyperglycemia (FH, FPG > 6.1 mmol/L) can affect live birth rates (LBR) in singleton intrauterine clinical pregnancy women with cryo-thawed embryo transfer (CET) cycles. Material and methods A retrospective cohort study (370 CET cycles with first singleton clinical intrauterine pregnancy and grouped by male FPG) was conducted to analyze the relationship between male FH and clinical pregnancy outcomes using binary logistic regression; the odds ratios (ORs) and 95% confidence intervals (CIs) were calculated as a measure of relevancy. Live birth rate was the main outcome measure. Results The live birth rate (LBR) was significantly lower [58.6% vs. 81.8%, P = 0.007, adjusted OR 0.635, 95% CI 0.456–0.884] and miscarriage rate (MR) was significantly higher [41.4% vs. 18.2%, P = 0.007, adjusted OR 1.575, 95% CI 1.131–2.195] in the FH group when compared with the Con group. There was no difference in healthy baby rate [88.2% vs. 89.6%, P = 0.058, adjusted OR 2.143, 95% CI 0.974–4.716] or abnormal birth weight rate (23.5% vs. 11.8%, P = 0.238, adjusted OR 2.859, 95% CI 0.777–10.460] between the FH and control group. No birth defects were observed in the present study. Conclusion Male FH is an independent risk factor for lower LBR and higher MR in singleton intrauterine pregnancy women with CET cycles.

show abstract

Influence of male hyperinsulinaemia on IVF outcome

Cited by 3 publications

References 39 publications

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males

Effect of metformin therapy and dietary supplements on semen parameters in hyperinsulinaemic males

Availability, effectiveness and safety of ART in sub-Saharan Africa: a systematic review

Effects of fasting hyperglycemia in men on pregnancy outcomes of singleton pregnant women with cryo-thawed embryo transfer

Contact Info

Product

Resources

About