Most civil structures exhibit nonlinear behavior during moderate to severe earthquakes. Consequently, inelastic analysis is needed for seismic design. Several dynamic and static analysis methods are available for the assessment and design of engineering structures. Two of the available methods in terms of nonlinear dynamic time history analysis and nonlinear static analysis, which is known as pushover analysis, are employed herein to comprehensively study and investigate the seismic performance of multi-story building structures with different floor systems. Moreover, the study is extended to assess the actual values of the response reduction/modification factor (R-factor) for each building model, then evaluate the values with the code-recommended design values. Three-dimensional finite element building models with 5, 10 and 15 stories are developed for the evaluation process. The advanced computer program ETABS is used for developing and analyzing the buildings considering material and geometrical nonlinearity. A suit of seven earthquake records is considered and scaled according to the ASCE-16 seismic design code to excite the building models. The obtained results evidently reveal that the type of floor slab significantly impacts the seismic response of the building. More specifically, the effects of floor slabs on seismic demands are more evident in low- and mid-rise buildings. In addition, the type of slab system and height of the building have more influence on the response modification factors, especially for low-rise building models.