Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes

Dhasarathy, Archana; Roemmich, James N.; Claycombe, Kate J.

doi:10.1016/j.mam.2016.10.003

Cited by 18 publications

(13 citation statements)

References 215 publications

(237 reference statements)

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“…The exercise protocol was shown to act directly not only on body weight reduction, but on deposits of different fatty tissues such as visceral and epididymal, raising the hypothesis that these tissues may also contribute to the energy expenditure requested by the exercise. Findings found in this research corroborate similar results of swimming protocols used by other authors [26][27][28][29].…”

Section: Discussionsupporting

confidence: 93%

“…Beside that, the caloric expenditure occasioned during and after the physical activity helps to reduce the adverse effects of the body fat gather specially the one placed in the abdominal wall, adding the balanced energy intake can be prescribed as a proposal to prevent obesity. Yet there is no agreement in literature about intensity, frequency and duration of the physical activity and what kind of diet promote different adaptations and effects when it comes to obesity [25,26].…”

Section: Discussionmentioning

confidence: 99%

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Dietary supplementation with camu-camu and continuous exercises in the treatment of obesity

et al. 2018

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Objective The goal of this study were to investigate the effects of continuous exercise with/or without the ingestion the Camu-camu pulp in a rat model of obesity. Methods Neonate male Wistar rats, receiving monosodium glutamate, subcutaneously were separated into foour groups: sedentary group S (no treatment), exercise group E (continuous swimming training), Camu-camu group C (25mL of pulp of Camu-camu/day) and exercise and Camu-camu group EC (25mL of pulp of Camu-camu/day, continuous swimming). After 12 weeks, the animals were received euthanasia. Results The exercise program was conducted for five days for 12 weeks and the effects of supplementation with or without Camu-camu in obese rats were analyzed, showing that the relative levels of the variables cholesterol, triglycerides, glucose, High Density Lipoprotein and Low Density Lipoprotein and in all groups there was a significant reduction (.<0.001), except for the control group. Body weight and feed intake, epididymal and visceral fat deposits were not significantly different between the means of groups C and E, but these groups showed a significant difference when compared to the EC group (.<0.001). Conclusion The results demonstrate the effectiveness of continuous exercise and diet supplemented with Camu-camu fruit pulp to control obesity.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with camu-camu and continuous exercises in the treatment of obesity

et al. 2018

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“…63 activity in the adipocyte modify their fatty acid composition. 10,68,69 This could lead to obesity and metabolic disturbances in the offspring later in life. Third, the low-grade inflammation seen in obesity could also contribute to offspring's risks of cardiometabolic disease, since upregulation of inflammatory markers is seen in children of mothers with obesity, independent of offspring's BMI.…”

Section: Potential Mechanismsmentioning

confidence: 99%

Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta‐analysis of animal studies

et al. 2019

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SummaryObesity before and during pregnancy leads to reduced offspring cardiometabolic health. Here, we systematically reviewed animal experimental evidence of maternal obesity before and during pregnancy and offspring anthropometry and cardiometabolic health. We systematically searched Embase and Medline from inception until January 2018. Eligible publications compared offspring of mothers with obesity to mothers with a normal weight. We performed meta‐analyses and subgroup analyses. We also examined methodological quality and publication bias. We screened 2543 publications and included 145 publications (N = 21 048 animals, five species). Essential methodological details were not reported in the majority of studies. We found evidence of publication bias for birth weight. Offspring of mothers with obesity had higher body weight (standardized mean difference (SMD) 0.76 [95% CI 0.60;0.93]), fat percentage (0.99 [0.64;1.35]), systolic blood pressure (1.33 [0.75;1.91]), triglycerides (0.64 [0.42;0.86], total cholesterol (0.46 [0.18;0.73]), glucose level (0.43 [0.24;0.63]), and insulin level (0.81 [0.61;1.02]) than offspring of control mothers, but similar birth weight. Sex, age, or species did not influence the effect of maternal obesity on offspring's cardiometabolic health. Obesity before and during pregnancy reduces offspring cardiometabolic health in animals. Future intervention studies should investigate whether reducing obesity prior to conception could prevent these detrimental programming effects and improve cardiometabolic health of future generations.

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“…La nutrigenómica, entonces, es la disciplina que relaciona el papel de los nutrientes en la expresión génica; probablemente pronto se podría hacer estudios, tal como se hace actualmente con la farmacogenómica, para indicar a cada individuo la dieta que le conviene de acuerdo a sus genes. Esto podría incluso ser aplicable a la mujer gestante, quien podría introducir variantes en su dieta y en su esti lo de vida, acti vidad fí sica, y otros, para favorecer la expresión de genes benéfi cos para el desarrollo del embrión (9) . Se está experimentando también inducir modifi caciones epigenéti cas uti lizando medicamentos como ácido valproico para silenciar o potenciar la acti vidad de determinados genes, pero los resultados aun no son concluyentes.…”

Section: Factores Genéticos En Obesidadunclassified

“…Se está experimentando también inducir modifi caciones epigenéti cas uti lizando medicamentos como ácido valproico para silenciar o potenciar la acti vidad de determinados genes, pero los resultados aun no son concluyentes. Igualmente se experimenta en ratones la posibilidad de bloquear la formación de adipocitos mediante miR (9) , cuyos resultados, de confi rmarse, podrían ser úti les en el tratamiento de la obesidad severa. Aun queda mucho por descubrir en el campo de la epigenéti ca.…”

Section: Factores Genéticos En Obesidadunclassified

Obesidad y genética

Michelena¹

2017

An Fac med

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Resumen La obesidad se convierte en epidemia en muchos países, e incluye las zonas urbanas del Perú. Diversos estudios buscan dilucidar los factores que contribuyen a esta peligrosa epidemia, que tiene un evidente componente genético. En este artículo se trata de resumir lo que se conoce hasta el momento respecto a la genética de la obesidad. Palabras clave: Obesidad; Genética. Abstract Obesity is becoming epidemic in many countries, and includes urban areas of Peru. Various studies try to elucidate the factors that contribute to this dangerous epidemic that has an evident genetic component. In this review we try to summarize what is currently known with respect to genetics in obesity.

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Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes

Cited by 18 publications

References 215 publications

Dietary supplementation with camu-camu and continuous exercises in the treatment of obesity

Dietary supplementation with camu-camu and continuous exercises in the treatment of obesity

Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta‐analysis of animal studies

Obesidad y genética

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