Influence of meal weight and caloric content on gastric emptying of meals in man

Moore, John G.; Christian, Paul E.; Brown, Jadeda; Brophy, Colleen M.; Datz, Frederick L.; Taylor, Addison A.; Alazraki, Naomi P.

doi:10.1007/bf01296271

Cited by 105 publications

(49 citation statements)

References 10 publications

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“…Increasing the volume will speed emptying, but increasing the nutrient content will slow emptying. 17,18 Osmolality, temperature, and pH of drinks are of minor importance. 17,18 It should also be noted that gastric emptying time is a variable phenomenon in healthy subjects with significant inter-and intraindividual day-to-day differences.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 Osmolality, temperature, and pH of drinks are of minor importance. 17,18 It should also be noted that gastric emptying time is a variable phenomenon in healthy subjects with significant inter-and intraindividual day-to-day differences. 19 Our results have also shown that patients in the apple juice group experienced more thirst and hunger than those in the control and water groups (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

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Metabolic, hormonal and gastric fluid and pH changes after different preoperative feeding regimens

Naguib

Samarkandimb

Al-Hattab

et al. 2001

Can J Anesth/J Can Anesth

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metabolic, hormonal and gastric fluid and pH changes after different preoperative feeding regimens

Naguib

Samarkandimb

Al-Hattab

et al. 2001

Can J Anesth/J Can Anesth

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show abstract

“…So we discussed the transfer process in relation to the gastric emptying. Concerning gastric emptying, it is known that when the contents of the stomach are in a liquid state, the contents are emptied out generally with the first-order rate process (2,7,8). Therefore, we first analyzed the concentrations in plasma according to equation 1, which was derived from the model assumed to have a first-order transfer process.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic analysis of the effects of different foods on absorption of cefaclor

Oguma

Yamada

Sawaki

et al. 1991

Antimicrob Agents Chemother

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Cefaclor is an oral cephalosporin antibiotic which has a broad antibacterial spectrum. The purpose of this study was to investigate the effect of food on the absorption of cefaclor and to analyze kinetically the absorption process of this drug. Cefaclor was given to eight volunteers at five test times: after overnight fasting, after two rice meals (350 and 700 cal [1 cal = 4.184 JI), and after two bread meals (500 and 1,000 cal). Urinary recoveries of cefaclor and concentrations of the drug in plasma were determined for each administration. Areas under the concentration-time curves and urinary recoveries were not affected by food intake, but the maximum concentration of drug in serum was reduced and the time to maximum concentration of drug in serum was prolonged depending on the type and the quantity of the meal. The larger the quantity of the meal, the more the maximum concentration of drug in serum and the time to maximum concentration of drug in serum were affected. The rice meals affected the absorption process of cefaclor more than the bread meals. The concentrations of cefaclor in plasma following administration after overnight fasting were well fitted to a conventional one-compartment model with a first-order absorption process, but those after the other administrations were not fitted to the model. For the pharmacokinetic analysis of those data, it was necessary to introduce a transfer process from administration site to absorption site to the conventional model. The concentrations in plasma after rice and bread meals were best fitted to the model with a zero-order transfer process than to that with a first-order process. The velocity of the transfer process depended on the type and volume of the meal.

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“…Accordingly, cocoa may alleviate the effects of lactose in milk chocolate. Since solid consistency and high energy content of food delays gastric emptying (Moore et al, 1984;Notivol et al, 1984;Marciani et al, 2001), lactose eaten in milk chocolate may even induce fewer symptoms than the respective amount of lactose in chocolate milk. It has been previously demonstrated that consuming milk or lactose with a meal or other foods produces less breath hydrogen and gastrointestinal symptoms (Solomons et al, 1985;Martini & Savaiano, 1988;Dehkordi et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Tolerance of symptomatic lactose malabsorbers to lactose in milk chocolate

2003

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Objective: To study tolerance to lactose in milk chocolate among symptomatic lactose maldigesters. Design: Randomized cross-over study. Subjects: Twenty-seven adult lactose maldigesters with symptomatic lactose intolerance. Methods: A 100 g chocolate sample prepared with whole milk (12 g lactose), whole-milk powder (12 g lactose), low-lactose milk powder (2 g lactose) or lactose-free milk powder was eaten after an overnight fast. Gastrointestinal symptoms (flatulence, abdominal bloating, abdominal pain, borgorygmi and nausea) were recorded in a questionnaire during the following 8 h. Bowel movements and stool consistency were also registered during the test day. Results: The numbers of persons reporting different gastrointestinal symptoms or any of the symptoms did not differ significantly after eating the chocolate samples. No statistical differences were found in the estimated strength of the different symptoms or the total strength of all symptoms combined. Differences in the bowel frequency and stool consistency were also non-significant. Conclusions: Lactose malabsorbers with self-reported lactose intolerence did not differ in their response to milk chocolate samples containing different amounts of lactose.

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Influence of meal weight and caloric content on gastric emptying of meals in man

Cited by 105 publications

References 10 publications

Metabolic, hormonal and gastric fluid and pH changes after different preoperative feeding regimens

Metabolic, hormonal and gastric fluid and pH changes after different preoperative feeding regimens

Pharmacokinetic analysis of the effects of different foods on absorption of cefaclor

Tolerance of symptomatic lactose malabsorbers to lactose in milk chocolate

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