Influence of medicinal plants’ extracts of the Altai region on hematological and biochemical profiles of laboratory mice

Abstract

Purpose: to study the effect of oregano and marsh cinquefoil extracts on the hematological and biochemical profiles of laboratory mice.Materials and methods. The article presents a study of the effect of MC and O extracts on laboratory mice. The raw materials for the production of extracts were rhizomes of MC and above-ground parts of O collected in the Altai Krai. The effect of the extracts was studied on 54 two-month-old ICR mice of different sexes. Three experimental groups were formed: control, experimental with O extract (20 mg/kg) and experimental with MC extract (20 mg/kg). The following hematological and biochemical parameters were studied: the content of erythrocytes and hemoglobin, hematocrit, average volume of erythrocytes, the content of leukocytes and lymphocytes, the content of calcium, phosphorus, cholesterol, urea, glucose, triglycerides, total protein and albumin.Results. As a result of the study, it was revealed that the studied extracts are capable of having a significant effect on such metabolic parameters of laboratory mice as the content of glucose, cholesterol and total protein. The most significant effect was observed in female mice consuming the MC extract. Based on the results obtained, it was concluded that it is advisable to further study MC and O extracts as components for the development of hyperglycemic, hypolipidemic and restorative drugs based on medicinal plants.