Influence of melatonin on mutagenicity and anti-tumor effect of cyclophosphamide and nitrosomethylurea in mice

Musatov, Sergei; Rosenleld, S.V.; Togo, E. F.; Mikheev, V. S.; Amsimov, V.N.

doi:10.1016/s0959-8049(97)85466-4

Cited by 3 publications

(4 citation statements)

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“…The current work showed that co-treatment melatonin and/or selenium in periods of five treatment melatonin with cadmium chloride significantly decreases total abnormal metaphase and other aberrations when compared with cadmium chloride group. The present results are in agreement with the results obtained by (Musatov et al, 1997 reported that melatonin inhibited the formation of chromosomal aberrations in mice; Hanafy, 2007 indicated that melatonin could improve genetic damages, reduced frequency of structural and numerical chromosomal aberration induced by genotoxic agents. Kee et al, 1997 reported that selenium acts as anticlastogenic agents by preventing oxidative stress, thereby reduce breakage and frequency of chromosomal damage induced by genotoxic metals.…”

Section: Resultssupporting

confidence: 93%

Protective effects of Selenium and/or Melatonin against Cadmium Chloride induced Chromosomal aberrations in Swiss Albino mice Mus musculus BALB/c

Al-Attar¹,

Sofi²

2016

ZJPAS

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Section: Resultssupporting

confidence: 93%

Protective effects of Selenium and/or Melatonin against Cadmium Chloride induced Chromosomal aberrations in Swiss Albino mice Mus musculus BALB/c

Al-Attar¹,

Sofi²

2016

ZJPAS

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“…Melatonin has been found to inhibit X-ray-induced mutagenesis in human and mouse lymphocytes in vitro (171,172,173), to reduce Cis-platinum-induced genetic damage in the bone marrow of mice (72), to decrease hepatic DNA adduct formation caused by safrole in rats (155), and to protect rat hepatocytes from chromium (VI)-induced DNA singlestrand breaks in vitro (152). We studied the effect of melatonin on the induction of chromosome aberrations and sperm head anomalies in mice treated with cyclophosphamide, 1,2-dimethylhydrazine, and N-nitrosomethylurea and found that melatonin inhibited greatly the mutagenicity of these carcinogens (97).…”

Section: Effect Of Melatonin On the Longevity Of Fruit Fliesmentioning

confidence: 99%

Effects of Exogenous Melatonin—A Review

Anisimov

2003

Toxicol Pathol

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The results of studies on the effect of pineal indole hormone melatonin on the life span of mice, rats, fruit flies, and worms are critically reviewed. In mice, long-term administration of melatonin was followed by an increase in their life span in 12 experiments and had no effect in 8 of 20 different experiments. In D. melanogaster, the supplementation of melatonin to the nutrient medium during developmental stages gave contradictory results, but when melatonin was added to food throughout the life span, an increase in the longevity of fruit flies has been observed. Melatonin decreased the survival of C. elegans but increased the clonal life span of planaria Paramecium tertaurelia. Available data suggest antioxidant and atherogenic effects of melatonin. Melatonin alone turned out to be neither toxic nor mutagenic in the Ames test and revealed clastogenic activity in high concentration in the COMET assay. Melatonin inhibits mutagenesis induced by irradiation and by indirect chemical mutagens and inhibits the development of spontaneous and chemical-induced tumors in mice and rats. Further studies and clinical trials are needed to verify that melatonin is both safe and has geroprotector efficacy for humans.

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“… Not mutagenic in mice sperm head anomaly test; reduced sperm head anomaly rates. [ 120 ] GT In vivo cell system 10 mg/kg i.p. No adverse effects on rat peripheral blood micronucleus test.…”

Section: Safety Of Melatonin Administrationmentioning

confidence: 99%

“…A full range of genotoxicity tests, including in vitro non-mammalian [ 113 , [116] , [117] , [118] ] and in vitro mammalian cell systems [ 113 , 117 , 119 ], and in vivo mammalian system [ 120 , 121 ] tests consistently found no evidence that melatonin is genotoxic (neither mutagenic or clastogenic). Furthermore, several studies in various in vitro/in vivo systems have reported the anti-genotoxic action of melatonin [ [122] , [123] , [124] , [125] , [126] ], usually ascribed to its antioxidant activity.…”

Section: Safety Of Melatonin Administrationmentioning

confidence: 99%

Efficacy and safety of supplemental melatonin for delayed sleep–wake phase disorder in children: an overview

et al. 2020

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Delayed sleep–wake phase disorder (DSPD) is the most frequently occurring intrinsic circadian rhythm sleep–wake disorder, with the highest prevalence in adolescence. Melatonin is the first-choice drug treatment. However, to date melatonin (in a controlled-release formulation) is only authorised for the treatment of insomnia in children with autism or Smiths-Magenis syndrome. Concerns have been raised with respect to the safety and efficacy of melatonin for more general use in children, as melatonin has not undergone the formal safety testing required for a new drug, especially long-term safety in children. Melatonin is known to have profound effects on the reproductive systems of rodents, sheep and primates, as well as effects on the cardiovascular, immune and metabolic systems. The objective of the present article was therefore to establish the efficacy and safety of exogenous melatonin for use in children with DSPD, based on in vitro, animal model and clinical studies by reviewing the relevant literature in the Medline database using PubMed. Acute toxicity studies in rats and mice showed toxic effects only at extremely high melatonin doses (>400 mg/kg), some tens of thousands of times more than the recommended dose of 3–6 mg in a person weighing 70 kg. Longer-term administration of melatonin improved the general health and survival of ageing rats or mice. A full range of in vitro/in vivo genotoxicity tests consistently found no evidence that melatonin is genotoxic. Similarly long term administration of melatonin in rats or mice did not have carcinogenic effects, or negative effects on cardiovascular, endocrine and reproductive systems. With regard to clinical studies, in 19 randomised controlled trials comprising 841 children and adolescents with DSPD, melatonin treatment (usually of 4 weeks duration) consistently improved sleep latency by 22–60 min, without any serious adverse effects. Similarly, 17 randomised controlled trials, comprising 1374 children and adolescents, supplementing melatonin for indications other than DSPD, reported no relevant adverse effects. In addition, 4 long-term safety studies (1.0–10.8 yr) supplementing exogenous melatonin found no substantial deviation of the development of children with respect to sleep quality, puberty development and mental health scores. Finally, post-marketing data for an immediate-release melatonin formulation (Bio-melatonin), used in the UK since 2008 as an unlicensed medicine for sleep disturbance in children, recorded no adverse events to date on sales of approximately 600,000 packs, equivalent to some 35 million individual 3 mg tablet doses (MHRA yellow card adverse event recording scheme). In conclusion, evidence has been provided that melatonin is an efficacious and safe chronobiotic drug for the treatment of DSPD in children, provided that it is administered at the correct time (3–5 h before endogenous melatonin starts to rise in dim light (DLMO)), and in the correct (minimal effective) dose. As the stat...

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Influence of melatonin on mutagenicity and anti-tumor effect of cyclophosphamide and nitrosomethylurea in mice

Cited by 3 publications

References 0 publications

Protective effects of Selenium and/or Melatonin against Cadmium Chloride induced Chromosomal aberrations in Swiss Albino mice Mus musculus BALB/c

Protective effects of Selenium and/or Melatonin against Cadmium Chloride induced Chromosomal aberrations in Swiss Albino mice Mus musculus BALB/c

Effects of Exogenous Melatonin—A Review

Efficacy and safety of supplemental melatonin for delayed sleep–wake phase disorder in children: an overview

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