In this paper, analyze the impact of Activation energy, Diffusion thermo and thermal diffusion with heat and mass transfer inherent of over a vertical cone through Thermally Radiant Williamson nanofluid with saturated porous medium under the convective boundary condition in the presence of thermal radiation has been studied. The coefficients of Brownian and thermophoresis diffusions are also taken into consideration. The governing partial differential equations are reduced to a couple of nonlinear ordinary differential equations by using suitable transformation equations; these equations are then solved numerically with the use of the conventional fourth-order Runge Kutta method accompanied by the shooting technique. As a result, the effects of various physical parameters on the velocity, temperature, and nanoparticle concentration profiles as well as on the skin friction coefficient and rate of heat transfer are discussed with the aid of graphs and tables. This study has been directly applied in the pharmaceutical industry, microfluidic technology, microbial improved oil recovery, modelling oil and gas-bearing sedimentary basins, and many other fields. Further, to check the accuracy and validation of the present results, satisfactory concurrence is observed with the existing literature.