Influence of Mianserin on the Antinociceptive Effect of Morphine, Metamizol and Indomethacin in Mice

Pakulska, W; Czarnecka, E

doi:10.1016/s1043661802001299

Cited by 22 publications

(18 citation statements)

References 10 publications

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“…116 However, in a double-blind, cross-over study in humans, mianserin showed no analgesic effect in patients with diabetic neuropathy. 117 Similarly, mirtazapine, an analogue of mianserin, was effective in a rat model of neuropathic pain 118 but was not found efficacious in patients with chronic pain with concomitant depression, although it was well tolerated.…”

Section: Miscellaneous Antidepressants As Analgesicsmentioning

confidence: 99%

Efficacy of Antidepressants as Analgesics: A Review

Dharmshaktu¹,

Tayal²,

Kalra³

2012

The Journal of Clinical Pharma

279

189

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Persistent pain disorders are usually not adequately alleviated by nonsteroidal anti‐inflammatory drugs or other simple analgesics. Use of antidepressants as adjuvant therapy for the control of persistent pain is currently being practiced in disorders such as fibromyalgia, neuropathic pain, rheumatoid conditions, low back pain, and headache. This review describes the various mechanisms of analgesic activity of antidepressants along with their efficacy and tolerability profiles. Meta‐analyses and clinical studies of these agents were retrieved through the use of MEDLINE, Google scholar, and Cochrane databases. Antidepressants are effective in both neuropathic and non‐neuropathic pain and have diverse mechanisms independent of their antidepressant effects. Tricyclic antidepressants (amitryptiline, nortryptiline, desipramine) are effective compounds in the treatment of neuropathic pain, fibromyalgia, low back pain, and headaches. Studies are ongoing for the dual serotonin norepinephrine reuptake inhibitors (duloxetine, venlafaxine) in several persistent pain conditions and these may be recommended in neuropathic pain, migraines, and fibromyalgia. Evidence suggests that although the analgesic effects of selective serotonin reuptake inhibitors (fluoxetine, paroxetine, citalopram) are limited and inconsistent, yet they have a superior tolerability profile compared with tricyclic antidepressants.

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Section: Miscellaneous Antidepressants As Analgesicsmentioning

confidence: 99%

Efficacy of Antidepressants as Analgesics: A Review

Dharmshaktu¹,

Tayal²,

Kalra³

2012

The Journal of Clinical Pharma

279

189

View full text Add to dashboard Cite

show abstract

“…However, the decrease in morphine analgesia after prolonged pretreatment with some antidepressants was reported by several other authors [20] . Sertraline (SSRI) coadministered in a single dose increased morphine analgesia, whereas prolonged (14 days) administration suppresses such action [21] . In contrast to a single dose, TCA administered for 3 weeks reduced the analgesic effect of morphine [22,23] .…”

Section: Discussionmentioning

confidence: 99%

“…Antidepressants coadministered with opioids stimulate their analgesic action [7,11] , but multi-week coadministration of nortriptyline, fluvoxamine and mianserin with morphine in patients with chronic pain does not change the analgesic action of morphine [12][13][14] .…”

Section: Modification Of Fentanyl Analgesia By Antidepressantsmentioning

confidence: 99%

Modification of Fentanyl Analgesia by Antidepressants

2009

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Clinical practice often requires simultaneous administration of antidepressants with opioids (oncology, rheumatology). Coadministration may either attenuate or potentiate opioid analgesia. The purpose of this paper was to verify how the analgesic action of fentanyl (0.05 mg/kg) is affected by single administration as well as 4- or 21-day premedication with antidepressants characterized by various mechanisms of action. The effects of amitriptyline 3 mg/kg, moclobemide 5 mg/kg, fluoxetine 5 mg/kg and reboxetine 0.08 mg/kg were investigated. Experiments were conducted on normotensive Wistar Kyoto rats. The pain threshold was measured using an analgesimeter. It was concluded that the single administration of an antidepressant increases the analgesic action of fentanyl. Four-day premedication with fluoxetine and reboxetine significantly attenuated the antinociceptive action of fentanyl, whereas 21-day premedication with all antidepressants investigated (fluoxetine, amitriptyline, moclobemide, reboxetine) markedly decreased it. The potential clinical importance of this observation is discussed.

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“…13,36,37,49,51,53,57 Furthermore, several authors reported an antagonistic effect of the morphine-induced analgesia as well as nonnarcotic analgesia by benzodiazepines, while others have reported a potentiation of a nonnarcotic analgesic with alprazolam. 9,10,35,36 It has been recognized that nociception elicited in cutaneous and deep tissues activates different regions in the periaqueductal gray area and amygdala, structures that participate in anxiety/fear behavior and are involved in the activation of descending modulatory projections to the spinal cord. 24,31 Anxiety/ fear may alter animal and human nociception in both directions, depending on their origin.…”

Section: The Antinociceptive Effect Of Midazolammentioning

confidence: 99%