Influence of Microvessel Density and Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression on Prognosis in Vulvar Cancer

Obermair, Andreas; Kohlberger, Petra; Bancher‐Todesca, Dagmar; Tempfer, Clemens; Sliutz, Gerhard; Leodolter, Sepp; Reinthaller, Alexander; Kainz, Christian; Breitenecker, G.; Gitsch, G.

doi:10.1006/gyno.1996.0307

Cited by 72 publications

(45 citation statements)

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“…In contrast to previous reports of a relation between high MVD and poor outcome [8,10,16,23], our data suggest that a low FvW immunostaining-based MVD is related to a higher recurrence rate and poorer overall survival in women with LMS. FvW expression did not correlate with patient age, menopausal status, tumor size, tumor stage (UICC classification), histologic grade, or lymph node involvement, but the small size of the study population precluded multivariate analysis of its independent prognostic relevance.…”

Section: Discussioncontrasting

confidence: 99%

Prognostic value of von Willebrand factor, CD34, CD31, and vascular endothelial growth factor expression in women with uterine leiomyosarcomas

Poncelet¹,

Fauvet²,

Feldmann³

et al. 2004

Journal of Surgical Oncology

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Section: Discussioncontrasting

confidence: 99%

Prognostic value of von Willebrand factor, CD34, CD31, and vascular endothelial growth factor expression in women with uterine leiomyosarcomas

Poncelet¹,

Fauvet²,

Feldmann³

et al. 2004

Journal of Surgical Oncology

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“…In cutaneous SCC, VEGF is a marker of tumor invasion and metastasis (33) and altered bFGF expression is common (34). Some studies have shown a direct correlation between VEGF expression and tumor neovascularization as measured by MVD (35,36). However, this relationship between MVD and increased expression of VEGF has not been detected generally in human malignancies.…”

Section: Discussionmentioning

confidence: 99%

AEE788, a Dual Tyrosine Kinase Receptor Inhibitor, Induces Endothelial Cell Apoptosis in Human Cutaneous Squamous Cell Carcinoma Xenografts in Nude Mice

Park¹,

Younes²,

Jasser³

et al. 2005

Clinical Cancer Research

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Purpose: We investigated whether concomitant blockade of the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) signaling pathways by AEE788, a dual inhibitor of EGFR and VEGFR tyrosine kinases, would inhibit the growth of cutaneous squamous cell carcinoma (SCC) cells and human cutaneous cancer xenografts in nude mice.Experimental Design: We examined the effects of AEE788 on the phosphorylation of EGFR and VEGFR-2 in cutaneous SCC cells expressing EGFR and VEGFR-2 and cutaneous SCC cell growth and apoptosis. We assessed the in vivo antitumor effects of AEE788 in a xenograft model in nude mice. AEE788 (50 mg/kg) was given orally thrice weekly to mice that had been s.c. injected with Colo16 tumor cells. Mechanisms of in vivo AEE788 activity were determined by immunohistochemical analysis.Results: Treatment of cutaneous SCC cells with AEE788 led to dose-dependent inhibition of EGFR and VEGFR-2 phosphorylation, growth inhibition, and induction of apoptosis. In mice treated with AEE788, tumor growth was inhibited by 54% at 21 days after the start of treatment compared with control mice (P < 0.01). Immunohistochemical analysis revealed that AEE788 inhibited phosphorylation of EGFR and VEGFR and induced apoptosis of tumor cells and tumor-associated endothelial cells.Conclusions: In addition to inhibiting cutaneous cancer cell growth by blocking EGFR and VEGFR signaling pathways in vitro, AEE788 inhibited in vivo tumor growth by inducing tumor and endothelial cell apoptosis.

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“…The intensity of angiogenesis has been associated with poor prognosis in numerous cancers (9)(10)(11)(12)(13)(14)(15)(16)(17)(18). In endometrial carcinoma (EC), some investigators have shown that microvessel (MV) counts might be an independent prognostic factor (18,19), whereas others have been unable to confirm these findings (20).…”

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confidence: 99%

Endoglin (CD105) Expression in Endometrial Carcinoma

Saad

Jasnosz

Tung

et al. 2003

International Journal of Gynecological Pathology

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Tumor angiogenesis plays an important role in tumor growth and metastasis. We evaluated endoglin (CD105) as an endothelial marker of angiogenesis in endometrial carcinoma (EC) and its prognostic significance. Fifty-five cases of EC, 10 cases of complex endometrial hyperplasia with atypia (CHA), and 10 cases of simple hyperplasia (SH) were immunohistochemically stained for endoglin, CD31, and vascular endothelial growth factor (VEGF). Positively stained microvessels (MV) were counted in densely vascular foci (hot spots) in a 400x field in each specimen. For VEGF, intensity of staining was scored on three-tiered scale. Results were correlated with other prognostic parameters using appropriate statistics. Endoglin staining demonstrated significantly more MV than did CD31 (mean 30.8 +/- 10.95 vs. 13.38 +/- 7.53, p < 0.001). There was a positive correlation of both endoglin and CD31 MV counts with tumor differentiation (p < 0.05) and the depth of invasion (p < 0.01). However, only endoglin counts correlated significantly with the presence of angiolymphatic invasion (p < 0.01), lymph nodes metastases (p < 0.01), and tumor stage (p < 0.001). VEGF expression in EC had a significant correlation with angiolymphatic invasion (p < 0.01) and lymph node status (p < 0.05) but not with other prognostic parameters. Endoglin and VEGF showed significant differences between CHA and SH (p < 0.001). Our study showed that endoglin, by staining the proliferating MV in EC, is a more specific and sensitive marker for tumor angiogenesis than is the commonly used pan-endothelial marker, CD31. Endoglin staining also had prognostic significance, with positive correlation with angiolymphatic invasion, lymph node metastases, and tumor stage.

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Influence of Microvessel Density and Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression on Prognosis in Vulvar Cancer

Cited by 72 publications

References 0 publications

Prognostic value of von Willebrand factor, CD34, CD31, and vascular endothelial growth factor expression in women with uterine leiomyosarcomas

Prognostic value of von Willebrand factor, CD34, CD31, and vascular endothelial growth factor expression in women with uterine leiomyosarcomas

AEE788, a Dual Tyrosine Kinase Receptor Inhibitor, Induces Endothelial Cell Apoptosis in Human Cutaneous Squamous Cell Carcinoma Xenografts in Nude Mice

Endoglin (CD105) Expression in Endometrial Carcinoma

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