Influence of mild infections on iron status parameters in women of reproductive age

Eskeland, Benedicte; Bærheim, Anders; Ulvik, Rune J.; Hunskaar, Steinar

doi:10.1080/028134302317282752

Cited by 31 publications

(28 citation statements)

References 18 publications

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“…2 Because of the effect of inflammation on the serum ferritin concentration, calculation of body iron was not performed in subjects with a CRP concentration greater than 20 mg/L. 9 Data are presented as arithmetic mean and standard deviation with the exception of serum ferritin values, which were transformed as logarithms. Correlations were calculated using the Pearson correlation coefficient.…”

Section: Discussionmentioning

confidence: 99%

The influence of high-altitude living on body iron

Cook

Boy

Flowers

et al. 2005

Blood

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The quantitative assessment of body iron based on measurements of the serum ferritin and transferrin receptor was used to examine iron status in 800 Bolivian mothers and one of their children younger than 5 years. The survey included populations living at altitudes between 156 to 3750 m. Body iron stores in the mothers averaged 3.88 ؎ 4.31 mg/kg (mean ؎ 1 SD) and 1.72 ؎ 4.53 mg/kg in children. No consistent effect of altitude on body iron was detected in children but body iron stores of 2.77 ؎ 0.70 mg/kg (mean ؎ 2 standard error [SE]) in women living above 3000 m was reduced by one-third compared with women living at lower altitudes (P < .001). One half of the children younger than 2 years were iron deficient, but iron stores then increased linearly to approach values in their mothers by 4 years of age. When body iron in mothers was compared with that of their children, a striking correlation was observed over the entire spectrum of maternal iron status (r ‫؍‬ 0.61, P < .001). This finding could provide the strongest evidence to date of the importance of dietary iron as a determinant of iron status in vulnerable segments of a population.

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Section: Discussionmentioning

confidence: 99%

The influence of high-altitude living on body iron

Cook

Boy

Flowers

et al. 2005

Blood

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“…8/2013 om kosttilskudd ved jernmangel, hvor de beskriver effekten av jerntilskudd hos friske voksne forsøksper-soner med jernmangel (1). Jeg ønsker å utfordre enkelte biokjemiske analyser og resultater presentert i studien.…”

Section: Akuttfaseprotein Og/eller Jernlager1285unclassified

R. J. Ulvik svarer:

Ulvik¹

2013

Tidsskriftet

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1285ble erstattet av vanfør > handikappet > funksjonshemmet > person med funksjonshemning > person med nedsatt funksjonsevne, eller hvordan gamlehjem ble til aldershjem > sykehjem > bolig for eldre > bo-og rehabiliteringssenter (3). Man forsøker seg på omskrivninger og nye måter å si vanskelige ting på, men som regel varer det ikke lenge før de negative konnotasjonene følger etter, som nissen på lasset. Når et ord blir negativt ladet, finner vi på et nytt. Det blir fort en lang, lang rekke (3).Antakelig spiller det ikke så stor rolle hva Frahm Jensen og jeg måtte mene. Dersom mange nok synes at «pasient» er et ugreit begrep, ja, da blir det nok ugreit (4). erlend.hem@medisin.uio.no Erlend Hem

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“…The underlying mechanisms are reduced iron absorption from the intestinal lumen, impaired release of recycled iron from macrophages and increased iron uptake by reticuloendothelial cells. The rise in the serum ferritin concentration (S-ferritin) that occurs during inflammation and infection, is also well-known (Elin et al, 1977;Birgegard et al, 1978;Hulthen et al, 1998;Eskeland et al, 2002). The mediator responsible for the altered iron kinetics induced by infection/inflammation appears to be hepcidin, a recently discovered peptide synthesized in the liver in response to interleukin-6 (IL-6) (Kemna et al, 2005;Roy and Andrews, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Although the increase in S-ferritin remains for several weeks after recovery from infection (Hulthen et al, 1998;Eskeland et al, 2002), it also seems to be the slowest of the iron markers to respond (Birgegard et al, 1978;Eskeland et al, 2002). Despite this knowledge, the exact duration and the time course of this infection-induced alteration in iron kinetics has not been clearly established.…”

Section: Introductionmentioning

confidence: 99%

“…Despite this knowledge, the exact duration and the time course of this infection-induced alteration in iron kinetics has not been clearly established. The effects of mild infections on iron status parameters, before and beginning on the third day following onset, have previously been studied (Eskeland et al, 2002). There are also several studies on induced (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Capturing the onset of the common cold and its effects on iron absorption

Hoppe

Hulthén

2007

Eur J Clin Nutr

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Hypoferremia is a well-known response to infections and inflammatory disorders. It seems to be managed by the key mediator of iron kinetics, hepcidin. There are several studies on induced-acute phase reactions. However, to our best knowledge there are no previous published reports on the outbreak of a common cold and its initial effect on iron kinetics. The objective of this case report is to describe such an observation. From an apparently healthy state in the morning we observed, in a 28-year-old male, every hour for 6 h the outbreak of a common cold and the modulations in the levels of serum iron (S-Fe) and interleukin-6 (IL-6). Despite a 100 mg oral iron loading there was a substantial reduction in S-Fe, which seemed to precede the IL-6 peak. Interestingly, this observed succession is in conflict with the proposed infection chain of order in which IL-6 stimulates hepcidin induction.

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Influence of mild infections on iron status parameters in women of reproductive age

Cited by 31 publications

References 18 publications

The influence of high-altitude living on body iron

The influence of high-altitude living on body iron

R. J. Ulvik svarer:

Capturing the onset of the common cold and its effects on iron absorption

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