Influence of millimeter-wave electromagnetic radiation on nitric oxide synthesis with aging of vessel endothelium in vitro

Molodzova, I. D.; Medvedev, D S; Polyakova, V. I.; Linkova, N. S.; Gurko, G I

doi:10.1134/s2079057015020083

Cited by 1 publication

(1 citation statement)

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“…Both CRF and AVP are essential for the coordination of behavioral and metabolic responses to stress [ 50 ]. Some authors reported an influence of millimeter-wave electromagnetic emission on vasopressin expression that was dependent on exposure to irradiation, which suggests that vasopressin may act in the initial response to acute irradiation stimulation [ 60 ]. However, the stress response in the female rats used in that experiment was described by other authors to be different than in males [ 18 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain

Othman

López-Furelos

Leiro

et al. 2021

IJMS

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Brain tissue may be especially sensitive to electromagnetic phenomena provoking signs of neural stress in cerebral activity. Fifty-four adult female Sprague-Dawley rats underwent ELISA and immunohistochemistry testing of four relevant anatomical areas of the cerebrum to measure biomarkers indicating induction of heat shock protein 70 (HSP-70), glucocorticoid receptors (GCR) or glial fibrillary acidic protein (GFAP) after single or repeated exposure to 2.45 GHz radiation in the experimental set-up. Neither radiation regime caused tissue heating, so thermal effects can be ruled out. A progressive decrease in GCR and HSP-70 was observed after acute or repeated irradiation in the somatosensory cortex, hypothalamus and hippocampus. In the limbic cortex; however, values for both biomarkers were significantly higher after repeated exposure to irradiation when compared to control animals. GFAP values in brain tissue after irradiation were not significantly different or were even lower than those of nonirradiated animals in all brain regions studied. Our results suggest that repeated exposure to 2.45 GHz elicited GCR/HSP-70 dysregulation in the brain, triggering a state of stress that could decrease tissue anti-inflammatory action without favoring glial proliferation and make the nervous system more vulnerable.

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