The article shows the results of research on the development of methods for increasing the yield of spring durum wheat (Triticum Durum) in the system of application of liquid mineral fertilizers Megamix in the pre-sowing preparation of seeds, processing of crops during vegetation when applying mineral fertilizers N16P16K16 in the pre-sowing preparation of soil in the conditions of the forest-steppe of the Middle Volga region. The research was carried out at the experimental field of the Samara State Agrarian University in 2017-2020. During the three-factor field experiment, the assessment of the main biometric indicators was carried out: the completeness of seedlings and the preservation of plants in crops, the formation of aboveground mass and accumulation of dry matter, photosynthetic activity with the analysis of leaf area, the formation of photosynthetic potential and the net productivity of photosynthesis. It is established that the best indicators are formed on variants with the treatment of the seed material with Megamix Seeds or MegamixProfi preparations, followed by a two-time treatment on vegetation with MegamixProfi 0.5 l/ha (in the tillering phase)+ Megamis Nitrogen 0.5l / ha (in the phase of the flag leaf), against the background of fertilization N16P16K16. It was revealed that the completeness of seedlings is formed here at the level of 78.0 ...77.7%. The use of Megamix preparations in the seed treatment system + the treatment of crops with stimulating preparations Megamix provides the maximum increase in aboveground mass in the variant of seed treatment Megamix Seeds and treatment of crops with the preparation Megamix Pro 1582.0 g / m2, as well as a mixture of preparations Megamix Pro + Megamix Nitrogen – 1614.0 g/m2 against the background of the introduction of N16P16K16. On these variants, the maximum leaf area and photosynthetic potential of 0.776...0.981 million m2 / ha days are formed and, as a result, the maximum yield with indicators of 2.89...3.03 t / ha. It was found that the use of liquid mineral fertilizers on all variants of the experiment significantly increases the yield of spring durum wheat.