Influence of modifiers on the performance of Ru-supported catalysts on the stereoselective hydrogenation of 4-acetamidophenol

Selective hydrogenation of paracetamol to acetamidocyclohexanone with silylated SiO2 supported Pd-based catalysts

“…Traditionally, supported Pd catalysts showed high selectivity to substituted cyclohexanone in the catalytic hydrogenation reaction, 6,7 while the hydrogenation of keto was fast for Ru-catalysts and leaded directly to the 4-acetamidocyclohexanols. 8 Products of hydrogenolytic cleavage can also be observed with a nickel catalyst. 9,10 There are many studies dealing with the hydrogenation of paracetamol to produce acetamidocyclohexanols and the cis/trans stereoselectivity.…”

“…17 In the same way, the hydrophilic oxygen-containing groups on the carbon support improve the solubility and act as the site for further chemical derivatization (amidation or esterication). 18 Bachiller-Baeza et al, 8,12 aer investigating the inuence of different supports and promoters on the stereoselective hydrogenation of paracetamol to 4-acetamidocyclohexanol, found that the OH groups on carbonsupported catalysts diminished the activity in the reaction explaining the catalytic performance as a function of the acidbase properties of the catalyst surface. Kim et al 19 increased the activity of SBA-15 supported Co catalysts for the FT synthesis via a hydrophobic silylation of the support, and these groups on SBA-15 enhanced the reducibility of the cobalt oxide species due to the weaker cobalt oxide-support interaction.…”