Influence of monocalcium phosphate on the properties of bioactive magnesium phosphate bone cement

Lv, Shaochun; Qu, Tianyu; Al-Ward, Hisham; Mu, Liting; Qiu, Hongbin; Zhang, Yunlong

doi:10.21203/rs.3.rs-1272878/v1

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…It has been widely used in biological materials, waste treatment, construction materials, etc. [7][8][9][10][11][12][13]. However, in the process of its use, it has been found that magnesium phosphate cement has poor water resistance [9,[14][15][16][17][18]; this greatly restricts its application in many scenarios [9,[14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Effect of Metakaolin on the Water Resistance of Magnesium Phosphate Cement Mortar

Wu,

Jiao,

Cao

et al. 2023

Coatings

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In order to study the effect of metakaolin on the water resistance of magnesium phosphate cement mortar, we took four factors as research objects: the setting time, fluidity, compressive strength, and water resistance of magnesium phosphate cement mortar. These were studied after adding equal gradations of metakaolin, and we then carried out SEM microcosmic experiments on the best group. The results showed that with the increase in metakaolin content, the setting time of magnesium phosphate cement decreased gradually, and the fluidity of the mortar decreased as a whole. The effect of metakaolin on the fluidity of the magnesium phosphate cement mortar was not significant when the content of metakaolin was less than 8%. Metakaolin was able to improve the pore structure of magnesium phosphate cement mortar; for example, it improved its compressive strength and water resistance due to both chemical and physical interactions. The water resistance of mortar samples in the same timeframe increased first and then decreased with the increase in metakaolin content. When the content of metakaolin was 12%, the water resistance of magnesium phosphate cement mortar achieved the optimal results. A 50.32% improvement of the 56 d strength retention rate and a 54.89% improvement of the 90 d strength retention rate proves its effective long-term water resistance.

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Section: Introductionmentioning

confidence: 99%

Effect of Metakaolin on the Water Resistance of Magnesium Phosphate Cement Mortar

Wu,

Jiao,

Cao

et al. 2023

Coatings

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Functionalized Magnesium Phosphate Cement Induces In Situ Vascularized Bone Regeneration via Surface Lyophilization of Chondroitin Sulfate

Gong,

Yang,

Zhang

et al. 2023

Biomedicines

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Bone defect repair poses significant challenges in orthopedics, thereby increasing the demand for bone substitutes. Magnesium phosphate cements (MPCs) are widely used for bone defect repair because of their excellent mechanical properties and biodegradability. However, high crystallinity and uncontrolled magnesium ion (Mg2+) release limit the surface bioactivity of MPCs in bone regeneration. Here, we fabricate chondroitin sulfate (CS) as a surface coating via the lyophilization method, namely CMPC. We find that the CS coating is uniformly distributed and improves the mechanical properties of MPC through anionic electrostatic adsorption, while mediating degradation-related controlled ion release of Mg2+. Using a combination of in vitro and in vivo analyses, we show that the CS coating maintained cytocompatibility while increasing the cell adhesion area of MC3T3-E1s. Furthermore, we display accelerated osteogenesis and angiogenesis of CMPC, which are related to appropriate ion concentration of Mg2+. Our findings reveal that the preparation of a lyophilized CS coating is an effective method to promote surface bioactivity and mediate Mg2+ concentration dependent osteogenesis and angiogenesis, which have great potential in bone regeneration.

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Hydration Behavior of Magnesium Potassium Phosphate Cement: Experimental Study and Thermodynamic Modeling

et al. 2022

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The microstructure and performance of magnesium potassium phosphate cement (MKPC), a kind of magnesium phosphate cement (MPC), are determined by the hydration products. In this paper, the hydration behavior of MKPC is investigated through various material characterization methods and thermodynamic modeling, including X-ray diffraction (XRD), thermogravimetric and differential scanning calorimeter (TG/DSC), scanning electron microscopy (SEM), mercury intrusion porosimetry (MIP) and GEMS software. The results of XRD, TG/DSC and SEM all indicate that K-struvite (MgKPO4·6H2O) is the main hydration product of MKPC. When the curing age is 1 day and 28 days, the TG data indicate that the mass loss of MKPC in the range of 60–200 °C is 17.76% and 17.82%, respectively. The MIP results show that the porosity of MKPC is 29.63% and 29.61% at the curing age of 1 day and 28 days, respectively, which indicates that the structure of MKPC becomes denser with the increase in curing age. In addition, the cumulative pore volume of MKPC at the curing age of 28 days is 2.8% lower than that at 1 day, and the pore diameters are shifted toward the small pores. Furthermore, the thermodynamic modeling is well suited to make an analysis of the hydration behavior of MKPC.

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Influence of monocalcium phosphate on the properties of bioactive magnesium phosphate bone cement

Cited by 3 publications

References 16 publications

Effect of Metakaolin on the Water Resistance of Magnesium Phosphate Cement Mortar

Effect of Metakaolin on the Water Resistance of Magnesium Phosphate Cement Mortar

Functionalized Magnesium Phosphate Cement Induces In Situ Vascularized Bone Regeneration via Surface Lyophilization of Chondroitin Sulfate

Hydration Behavior of Magnesium Potassium Phosphate Cement: Experimental Study and Thermodynamic Modeling

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