Influence of Monosodium Glutamate on Body Mass and Development of Obesity (Literature Review)

Hordiienko, L. P.

doi:10.29254/2077-4214-2017-4-3-141-33-37

Cited by 1 publication

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these values depend on the sodium glutamate content in food products and individual taste preferences. For our study, we chose a dosage of 70 mg/ kg of sodium glutamate (equivalent to 600 or 816 mg per day for an average-weight person of 60 or 70 kg) based on preclinical animal studies that demonstrated toxic effects on the heart, liver, kidneys, and other systems at high concentrations of sodium glutamate (0.5-6 g) [6]. To draw accurate conclusions regarding the use of lower concentrations of sodium glutamate, further research is necessary.…”

Section: Discussionmentioning

confidence: 99%

“…One of the most widely used additives in Ukraine and worldwide is sodium glutamate [8,9,11], which enhances appetite and intensifies the taste of products, leading to increased daily food consumption. Excessive energy in the body can disrupt metabolism, contribute to overweight, and ultimately lead to obesity and organ system disorders [2,4,6,18]. Therefore, studying the effects of sodium glutamate on various systems and organs of the body, particularly in association with the state of the pancreas, is an important medical and social issue.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, studying the effects of sodium glutamate on various systems and organs of the body, particularly in association with the state of the pancreas, is an important medical and social issue. Consequently, one approach to expanding our understanding of the effects of sodium glutamate is to investigate its pathogenesis using experimental animal models [5,6,9,11]. This approach is an integral part of modern medicine as it allows for the creation of models and provides unlimited possibilities for studying causal factors that contribute to pathogenesis depending on the research objectives.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of morphological changes of the pancreas in the conditions of experimental action of sodium glutamate

Litvak

2023

Rep. of Morph.

View full text Add to dashboard Cite

Sodium glutamate, also known as monosodium glutamate (MSG), is frequently used as a flavor enhancer in the food industry. Excessive consumption of sodium glutamate can be harmful to human health. The aim of this study was to investigate the morphological features of the exocrine part of the pancreatic gland under experimental conditions with prolonged exposure to sodium glutamate in the diet. In the experimental study on rats after modeling the action of monosodium glutamate (sodium glutamate) at a dose of 70 mg/kg body weight, the exocrine part of the pancreatic gland was examined using light and electron microscopy after 2, 3, and 5-7 weeks. The experimental study was conducted on white male laboratory rats of reproductive age with an average weight of 168.0±5.0 g. The animals were randomized into two groups: group 1 (n=6) included intact rats and group 2 (n=15) consisted of animals receiving sodium glutamate in their diet. Histological specimens were stained with hematoxylin, eosin, and azan, and electron microscopy samples were stained using the Reynolds method. The results were statistically analyzed using ANOVA analysis with Statistics 20.0.0.2 software. At the early stage of the experiment, changes were observed in the acini with the formation of small clusters comprising 2-3 acinar cells exhibiting increased accumulation of zymogen, which is an early important sign of pancreatitis. Swelling and replacement of the pancreatic gland with connective and adipose tissue progressed over the study period and were accompanied by structural alterations in the pancreatic gland. Round-cell infiltrates appeared in the areas where ducts and vascular bundles were located starting from the 5th week of observation, indicating the development of an inflammatory process. Histopathological changes at the 6th and 7th weeks following prolonged administration of sodium glutamate were similar to the pattern of pancreatitis in humans. Atrophy, degenerative changes, and inflammation were observed in the exocrine part of the pancreatic gland after 6-7 weeks of prolonged oral sodium glutamate intake. Thus, prolonged inclusion of sodium glutamate at a dose of 70 mg/kg body weight in the diet leads to irreversible destructive, degenerative, and inflammatory changes in the pancreatic gland.

show abstract

Section: Discussionmentioning

confidence: 99%