Influence of Moringa (Moringa oleifera) enriched ice creams on rats’ brain: Exploring the redox and cholinergic systems

Ademosun, Ayokunle O.; Oboh, Ganiyu; Ajeigbe, Olufunke Florence

doi:10.1016/j.crfs.2022.01.021

Cited by 9 publications

(4 citation statements)

References 37 publications

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“…MO were widely used to control blood glucose and its metabolism through multiple mechanisms (Figure 2). First, the plant extracts have been approved to inhibit many enzymes that could control glucose absorption or advanced glycation as intestinal α-glucosidase and pancreatic α-amylase [130,[138][139][140]. Another mechanism includes its ability to inhibit Na + -dependent glucose uptake [141,142].…”

Section: Moringa Oleifera and Glucose Statusmentioning

confidence: 99%

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Abdelazim,

Afifi,

Abu-Alghayth

et al. 2024

Journal of Food Biochemistry

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Plants could be used for multiple medicinal purposes. Moringa oleifera (MO) is considered the most famous plant used for this purpose. The present review aimed to spot the light on the recent medicinal, biochemical, and nutritional applications of MO. The plant contains a huge number of nutrients such as fatty acids, amino acids, proteins, polysaccharides, minerals, and vitamins. It has been used to control glucose, lipids, proteins, minerals, vitamins, hormones, and antioxidants in many animals and human models. Its medicinal applications are also varied and wide; it could be used to control and manage lots of disorders. Extracts and isolated ingredients from the plant open the way for many researchers all over the world to study its biochemical and medicinal impact on many experimental and clinical models. The present review spots the light on the recent medicinal and biochemical significance of MO opening the discussion and demonstrating the strengths and weaknesses in the MO research area. Regardless of the contrary concept, we considered MO a promising plant that could be studied for its medicinal applications on both biochemical and molecular levels. We recommended further research on the molecular effects of MO in healthy and diseased models.

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Section: Moringa Oleifera and Glucose Statusmentioning

confidence: 99%

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Abdelazim,

Afifi,

Abu-Alghayth

et al. 2024

Journal of Food Biochemistry

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“…Inhibitor of butyrylcholinesterase (BChE); inhibitor of acetylcholinesterase (AChE); lower the glycemic index, total cholesterol, triglycerides, and lowdensity lipoprotein cholesterol (LDL-C) level; increase high-density lipoprotein cholesterol (HDL-C) in plasma [15] Zingiber officinale Antioxidant, anti-inflammatory, increase expression of nerve growth factor (NGF) [16] Allium sativum Antioxidant, neuroprotective agent, inhibitor of AChE and BChE enzymes, antineuroinflammatory [17] Annona crassiflora Antibacterial, antimutagenic, anti-inflammatory, antinociceptive, hepatoprotective, and antitumoral, inhibitor of AChE [18] Citrus aurantium Anti-oxidative, antihypertensive, anti-hyperlipidemia, anti-diabetic, antiinflammatory, and hepato-protective potentials, neuroprotective [19] Annona muricata Anticancer, antioxidant, antiviral, anti-haemolytic, sedative and neuroprotective [20]…”

Section: Moringa Oleiferamentioning

confidence: 99%

A Machine Learning-Based Virtual Screening for Natural Compounds Potential on Inhibiting Acetylcholinesterase in the Treatment of Alzheimer’s Disease

Nur Azizah,

Dwi Suyanti,

Rezki Rasyak

et al. 2023

BIO Web Conf.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease caused by neural cell death, characterized by the overexpression of acetylcholinesterase (AChE) and extracellular deposition of amyloid plaques. Currently, most of the FDA-approved AChE-targeting drugs can only relieve AD symptoms. There is no proven treatment capable to stop AD progression. Many natural products are isolated from several sources and analyzed through preclinical and clinical trials for their neuroprotective effects in preventing and treating AD. Therefore, this study aims to explore and determine potential candidates from natural bioactive compounds and their derivatives for AD treatment targeting AChE. In this study, feature extraction was carried out on 1730 compounds from six plants resulting from literature studies with limitations on international journals with a minimum publication year of 2018 and database searches, then classified using machine learning algorithms: Random Forest (RF), Logistic Regression (LR), and Support Vector Machine (SVM). Hit compounds predicted to be active and inactive in the selected model were then processed through ensemble modelling. From 1730 compounds, there are 986 predicted active compounds and 370 predicted inactive compounds in the LR and RF ensemble modelling. Quercetin, Kaempferol, Luteolin, Limonene, γ-Terpinene, Nerolidol, and Linalool predicted active found overlapping in two to three plants in both LR and RF models.

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“…Immunity functions and antioxidant activity of animals and humans could be improved through the use of feed additives Mohammed 2013, 2014 a,b;Mohammed 2019;Ali et al, 2021;Ademosun et al, 2019Ademosun et al, , 2022. Bioactive compounds in M. oleifera have been shown to enhance immunity functions, antioxidant activities, and tissue protection in mammals (Kekana et al, 2020;Wen et al, 2022).…”

Section: Immunity Functions and Antioxidant Activitymentioning

confidence: 99%

Leverage of Moringa oleifera Supplementation on Performances, Biochemical, and Milk Profiles in Mammals

Masruri¹,

Zeidi²,

Mufarji³

et al. 2022

AAVS

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referred to as a miracle plant. M. oleifera is a nutritious and medicinal tree species-rich in protein, minerals, and vitamins. M. oleifera is a native plant in Pakistan, India, Bangladesh, and Afghanistan (Fahey, 2005). Supplementation of M. oleifera to animals and humans has received increased attention for its high contents of certain micro and macro-nutrients, which are important in medicine and nutrition for both humans and animals (Oyeyinka and Oyeyinka, 2018;Gupta et al., 2018). Leaves of M. oleifera are reported to contain substantial amounts of vitamins such as A, C, and E (Saini et al., 2014a,b;Hekmat et al., 2015), minerals such as potassium, calcium, magnesium, iron, copper, and manganese (Hekmat et al., 2015), nutrients such as protein, fiber, carotenoids, and tocopherols ( Jongrungruangchok et al., 2010;Moyo et al., 2011; Saini et al., 2014a,b). Some of the Moringa components are known to scavenge free radicals (DanMalam et al., 2001). Sub-

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Influence of Moringa (Moringa oleifera) enriched ice creams on rats’ brain: Exploring the redox and cholinergic systems

Cited by 9 publications

References 37 publications

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

A Machine Learning-Based Virtual Screening for Natural Compounds Potential on Inhibiting Acetylcholinesterase in the Treatment of Alzheimer’s Disease

Leverage of Moringa oleifera Supplementation on Performances, Biochemical, and Milk Profiles in Mammals

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