Influence of morphofunctional properties of platelets on the mechanical characteristics of the «bone tissue-implant» system in the experiment

Abstract

The use of platelet-based biological materials attracts special attention in regenerative medicine. The aim of the work was to study the peculiarities of mechanical properties of the system «peri-implant bone tissue-implant» depending on the morphofunctional properties of platelets under conditions of titanium rod implantation into the femur bone of rabbits. The number of platelets, mean volume (MPV), thrombocrit, ratio of large platelets to their total number, and ADP-induced aggregation were determined. During mechanical testing, we determined the maximum load on the «peri-implant bone-implant» system and its elastic properties. According to the result of preoperative determination of the morphofunctional characteristics of the platelets, the rabbits were divided into 2 groups: low platelet potential (LTP) and high platelet potential (HPP). Determination of the mechanical parameters of the «peri-implant bone tissue-implant» system showed that the maximum load in the NTP group was lower than in the VTP group, at the same time, no significant differences were found in the parameter characterizing elasticity (Elastic). The number as well as the morphofunctional characteristics of the circulating platelets in the blood have a significant impact on the strength characteristics of the newly formed peri-implant bone tissue.