Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography

Endo, Junko; Nomura, Masahiro; Morishita, Satofumi; Uemura, Nobuhisa; Inoue, Shuji; Kishi, Seiichiro; Kawaguchi, R; Iga, Akiko; Ito, Susumu; Nakaya, Yutaka

doi:10.1007/s005350200150

Cited by 37 publications

(32 citation statements)

References 25 publications

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“…These results were unexpected because we had hypothesized that an accumulation of stress and unhealthy lifestyle factors caused the suppression of EGG activity through hyperactivity of the sympathetic nervous system or hypoactivity of the parasympathetic nervous system. 14,30 A possible explanation for our findings is that a reduction in EGG activity may have directly reflected metabolic changes, including an increase in body fat and a decrease in HDL cholesterol, rather than the effects of accelerated sympathetic nervous functioning or decreased parasympathetic nervous functioning. Altered EGG activity has been frequently observed in obese patients.…”

Section: Discussionmentioning

confidence: 73%

Gastric electrical activity and cardiovascular risk factors in relation to autonomic nervous function, hormonal responses, and health-related lifestyles in young men

et al. 2006

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Section: Discussionmentioning

confidence: 73%

Gastric electrical activity and cardiovascular risk factors in relation to autonomic nervous function, hormonal responses, and health-related lifestyles in young men

et al. 2006

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“…Possible adverse events by concurrent use of mosapride would be to induce prolongation of the QT interval, torsades de pointes and/or ventricular fibrillation. However, both in vitro and in vivo studies demonstrated that mosapride did not have electrophysiological features of relevance for the proarrhythmic potentials in common with cisapride [11, 22]. The other adverse events reported in clinical studies were diarrhea, abdominal pain, and nausea, although they were not problematic.…”

Section: Discussionmentioning

confidence: 99%

“…Current consensus is that they are involved in visceral perception and promotion of gut motility [9]. Mosapride has been shown to have a prokinetic effect on gastric emptying in humans, which was evaluated using scintigraphy and ultrasound [10, 11]. Given the fact that PPIs are unstable under acidic conditions such as gastric lumen, it is reasonable that accelerated transfer of rabeprazole resulted in the presence of a much more undegraded form of rabeprazole in the upper small intestine, leading to an increase of absorption.…”

Section: Discussionmentioning

confidence: 99%

Prokinetics Influence the Pharmacokinetics of Rabeprazole

Arai¹,

Takeuchi²,

Watanabe³

et al. 2008

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Background: Proton pump inhibitors (PPIs) are unstable at a low PH. Accelerated transfer of PPIs to the upper small intestine may influence the pharmacokinetics of PPIs. Aim: To see if concomitant use of mosapride citrate with rabeprazole sodium influences the pharmacokinetics of the PPI. Methods: Two-way crossover pharmacokinetic studies were conducted in 9 healthy subjects. 20 mg of rabeprazole was given orally and plasma was obtained before and 1, 2, 3, 4, 5, 6 and 8 h after the dosing. Two weeks later, 5 mg of mosapride was given concomitantly with rabeprazole and plasma was collected as above. The plasma concentrations of rabeprazole were determined by high-performance liquid chromatography. The maximum plasma concentrations (C_max) and the area under the time-plasma concentration curve (AUC) of rabeprazole, and the time to maximum plasma concentration (t_max) were compared in the presence or absence of mosapride. Results: Concomitant use of mosapride resulted in significant increases of mean C_max and mean AUC with ratios of 1.57 and 1.47, respectively. The median t_max changed from 4 to 3 h, although the change was not significant. Conclusions: Mosapride significantly influenced pharmacokinetics of rabeprazole. Co-administration of mosapride could have some favorable effect in PPIs-based therapy.

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“…However, cisapride has been withdrawn from the market because of severe cardiac side effects including QT-interval prolongation and ventricular arrhythmias (9). As mosapride citrate hydrate (mosapride), another 5-HT 4 -receptor agonist, has been shown to have little effect on QT-interval (10), its coadministration with PEG-ELS has been investigated.…”

Section: Introductionmentioning

confidence: 99%

Effect of Mosapride Citrate Hydrate on the Colon Cleansing Action of Polyethylene Glycol Electrolyte Lavage Solution (PEG-ELS) in Guinea Pigs

et al. 2009

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Abstract. Polyethylene glycol electrolyte lavage solution (PEG-ELS) is widely used for colon cleansing prior to colonoscopy and colonic surgery. It has recently been shown that coadministration of PEG-ELS and mosapride citrate hydrate (mosapride), a selective 5-HT 4 -receptor agonist, is clinically useful for barium enema examination as it allows adequate barium coating. However, there is no report showing that mosapride has beneficial effects on colon cleansing and its underlying mechanism in experimental animals. In the present study, we investigated the effects of mosapride on colonic transit and on the colon cleansing action of PEG-ELS in guinea pigs. Mosapride (10 -20 mg/kg, i.g.) significantly enhanced colonic transit rate in guinea pigs. Although PEG-ELS alone showed adequate colon cleansing action, excess fluid remained in the colon. Coadministration of mosapride (20 mg/kg) and PEG-ELS, regardless of mosapride timing, reduced colonic content weight (dry residue and water amount) as compared to PEG-ELS alone. These findings suggest that mosapride enhances the colon cleansing action of PEG-ELS via an increase in colonic transit in guinea pigs, that is, it reduces not only fecal residue but also excessive fluid in the colonic lumen. It is therefore believed that coadministration of mosapride and PEG-ELS can allow better visualization in barium enema examination.

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Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography

Abstract: Mosapride citrate increased gastric motility and emptying without influencing autonomic nervous activity, suggesting that it may be very useful for elderly patients or patients with autonomic imbalance.

Cited by 37 publications

References 25 publications

Gastric electrical activity and cardiovascular risk factors in relation to autonomic nervous function, hormonal responses, and health-related lifestyles in young men

Gastric electrical activity and cardiovascular risk factors in relation to autonomic nervous function, hormonal responses, and health-related lifestyles in young men

Prokinetics Influence the Pharmacokinetics of Rabeprazole

Effect of Mosapride Citrate Hydrate on the Colon Cleansing Action of Polyethylene Glycol Electrolyte Lavage Solution (PEG-ELS) in Guinea Pigs

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