Influence of MRI on target volume delineation and IMRT planning in nasopharyngeal carcinoma

Emami, Bahman; Sethi, Anil; Petruzzelli, Guy J.

doi:10.1016/s0360-3016(03)00570-4

Cited by 109 publications

(69 citation statements)

References 29 publications

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“…The major type of tissue in the cephalic direction of the breast is the adipose tissue, which supports glandular breast tissue; therefore, the volume delineated by the MRI scan is larger than that delineated by the CT scan. Hence, MRI scan images will be of use in target volume delineation, and the fusion of images from the CT and MRI scans has already been widely used in target delineation for brain tumors, nasopharyngeal carcinoma and prostate cancer (25)(26)(27). Due to the profound difference in the posture of each patient, there are significant variations between the MRI and CT scan images of the breast; however, the fusion of the images of the MRI and CT scans is less feasible and is difficult for target volume delineation of the breast, therefore, this technique remains to be improved and investigated further.…”

Section: Discussionmentioning

confidence: 99%

Different methods for target volume delineation of glandular breast tissue following breast-conserving surgery in breast cancer: A comparative study

Liu

et al. 2015

Oncology Letters

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Section: Discussionmentioning

confidence: 99%

Different methods for target volume delineation of glandular breast tissue following breast-conserving surgery in breast cancer: A comparative study

Liu

et al. 2015

Oncology Letters

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“…Importantly, no detrimental effect on locoregional control was observed with volumetric contouring. [7][8][9] Several planning studies have underlined the benefit of incorporating MR images in head and neck radiotherapy planning with improvement of tumour delineation and reduction in interobserver variations compared with CT. [10][11][12] It also enables a more accurate delineation of neurological OARs such as the spinal cord, brain stem, optic chiasm and hippocampus, which is vital to avoid irreversible neurological sequelae. Nevertheless, the accuracy of MRI in this context is hugely dependent on the scanning position.…”

Section: Anatomical Mri Sequencesmentioning

confidence: 99%

The emerging potential of magnetic resonance imaging in personalizing radiotherapy for head and neck cancer: an oncologist's perspective

Wong

Panek

Bhide

et al. 2017

The British Journal of Radiology

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Head and neck cancer (HNC) is a challenging tumour site for radiotherapy delivery owing to its complex anatomy and proximity to organs at risk (OARs) such as the spinal cord and optic apparatus. Despite significant advances in radiotherapy planning techniques, radiation-induced morbidities remain substantial. Further improvement would require high-quality imaging and tailored radiotherapy based on intratreatment response. For these reasons, the use of MRI in radiotherapy planning for HNC is rapidly gaining popularity. MRI provides superior soft-tissue contrast in comparison with CT, allowing better definition of the tumour and OARs. The lack of additional radiation exposure is another attractive feature for intratreatment monitoring. In addition, advanced MRI techniques such as diffusion-weighted, dynamic contrast-enhanced and intrinsic susceptibility-weighted MRI techniques are capable of characterizing tumour biology further by providing quantitative functional parameters such as tissue cellularity, vascular permeability/perfusion and hypoxia. These functional parameters are known to have radiobiological relevance, which potentially could guide treatment adaptation based on their changes prior to or during radiotherapy. In this article, we first present an overview of the applications of anatomical MRI sequences in head and neck radiotherapy, followed by the potentials and limitations of functional MRI sequences in personalizing therapy. INTRODUCTIONRadical radiotherapy (RT) is integral to the management of head and neck cancer (HNC) in both the primary and adjuvant settings. Advances in computer-assisted radiological techniques over the past two decades have in turn revolutionized radiotherapy planning. Development of advanced radiotherapy planning techniques such as intensity-modulated radiotherapy (IMRT) and volumetricmodulated arc therapy have allowed for better dose conformation to the tumour target and sparing of surrounding normal tissues. HNC was one of the first tumour sites where IMRT was widely implemented owing to a significant reduction in radiation-induced xerostomia in comparison with three-dimensional conformal planning.

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“…MRI is commonly used in assessment of local involvement of NPC, which can clearly show the involvement of soft tissue, bone as well as the intracranial lesion [3,4]. On the contrary, 18 F-FDG…”

Section: Local Invasionmentioning

confidence: 99%

Use Of 18F-FDG PET/CT In The Diagnosis, Staging, Response Assessment And Prognosis Of Nasopharyngeal Carcinoma: An Updated Review

Yang

2014

J Nasopharyng Carcinoma

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Influence of MRI on target volume delineation and IMRT planning in nasopharyngeal carcinoma

Cited by 109 publications

References 29 publications

Different methods for target volume delineation of glandular breast tissue following breast-conserving surgery in breast cancer: A comparative study

Different methods for target volume delineation of glandular breast tissue following breast-conserving surgery in breast cancer: A comparative study

The emerging potential of magnetic resonance imaging in personalizing radiotherapy for head and neck cancer: an oncologist's perspective

Use Of 18F-FDG PET/CT In The Diagnosis, Staging, Response Assessment And Prognosis Of Nasopharyngeal Carcinoma: An Updated Review

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