Influence of Mulching Materials on Growth and
Saponin Content in Codonopsis lanceolate

Moon, Kyong Gon; Kim, Sang Un; Um, In Seok; Nam, Ju Hee; Cho, Young Son; Kim, Young Guk; Rho, Il Rae

doi:10.12972/kjhst.20180001

Cited by 1 publication

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“…The species is known to exert various pharmacological effects in humans. The roots of C. lanceolata mainly contain triterpenoid saponins, including codonolasides I-V and lancemaside A-G (Boo et al, 2016;Moon et al, 2018). The saponins exhibit anti-inflammatory effects for conditions such as bronchitis and cough, insomnia, and hypomnesia.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cytotoxicity on Human Cancer Cells and Antioxidant and Immune Cell Activities of Codonopsis lanceolata Root Extracts Stored at Different Temperatures and for Different Durations

Boo¹,

Shin²,

Kim³

et al. 2019

HST

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Codonopsis lanceolata is widely consumed in South Korea; however, its medicinal applications have not been explored in detail. The present study aimed to evaluate the xanthine oxidase (XO) inhibitory activity, reducing power, immune activity, and cytotoxicity of 30% ethanolic extracts of C. lanceolata roots stored at different temperatures (5, 15, 25, 35, and 45°C) and for different storage periods (0, 15, 30, 45, 60, 75, and 90 days). The growth of human T and B cells increased when treated with the root extracts stored at low temperatures for a short period, in a concentration-dependent manner. The XO inhibitory activity of the C. lanceolata roots stored at 5°C and 15°C was higher than for those stored at 45°C. The XO inhibitory activity of the C. lanceolata roots gradually deceased with increasing storage period. The reducing power of the extracts increased significantly in a concentration-dependent manner. Reducing power of the root storage temperature for all temperatures and storage periods using 5 mg·mL -1 extract was higher than that for the other extract concentrations. Cytotoxic activity of C. lanceolata roots on human cancer cell lines (e.g., HeLa, Calu-6, and MCF-7) decreased as storage temperatures decreased from 45°C to 5°C. The cytotoxic effect on the MCF-7 cell line was relatively higher than that on the HeLa and Calu-6 cell lines. The results suggest that the root extract of C. lanceolata can be used to modulate immune response and is also a natural food additive with excellent physiological functionality.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Cytotoxicity on Human Cancer Cells and Antioxidant and Immune Cell Activities of Codonopsis lanceolata Root Extracts Stored at Different Temperatures and for Different Durations

Boo¹,

Shin²,

Kim³

et al. 2019

HST

View full text Add to dashboard Cite

show abstract

Influence of Mulching Materials on Growth and Saponin Content in Codonopsis lanceolate

Abstract: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cited by 1 publication

References 10 publications

Evaluation of Cytotoxicity on Human Cancer Cells and Antioxidant and Immune Cell Activities of Codonopsis lanceolata Root Extracts Stored at Different Temperatures and for Different Durations

Evaluation of Cytotoxicity on Human Cancer Cells and Antioxidant and Immune Cell Activities of Codonopsis lanceolata Root Extracts Stored at Different Temperatures and for Different Durations

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