Influence of multidisciplinary therapeutic approach on fibromyalgia patients

Patru, S.; Pădureanu, Rodica; Dumitrescu, Florentina; Pădureanu, Vlad; Rădulescu, D; Drăgoi, Diana; Matei, Daniela

doi:10.3892/etm.2021.9960

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…The staff at our clinic continues to improve the healthcare provided to HIV-infected patients, especially the women of childbearing age, to allow them the chance to have a healthy child [ 13 , 14 , 15 , 16 , 17 , 18 ]. Our study shows that there were no differences in the sex of the newborns between the Constanta and Craiova RCs, with more than 50% being boys.…”

Section: Discussionmentioning

confidence: 99%

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

et al. 2023

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Background and Objectives: The present study assessed the fetal growth restriction and clinical parameters of both human immunodeficiency virus (HIV)-negative and HIV-positive newborns from HIV-infected mothers in two HIV-acquired immunodeficiency syndrome regional centers (RCs) in Constanta and Craiova, Romania, in order to evaluate the adverse birth-related outcomes. Materials and Methods: These represent a retrospective study conducted between 2008 and 2019, in which 408 pregnant HIV-positive women, 244 from Constanta RC and 164 from Craiova RC, were eligible to participate in the study. Consecutive singleton pregnancies delivered beyond 24 weeks of pregnancy were included. Growth restriction in newborns was defined as the birth weight (BW) being less than the third percentile, or three out of the following: BW < 10th percentile; head circumference (HC) < 10th percentile; birth length (BL) < 10th percentile; prenatal diagnosis of fetal growth restriction; and maternal pregnancy information. Of the 244 newborns delivered in Constanta, RC, 17 were HIV-positive, while in Craiova, RC, of the 164 newborns, 9 were HIV-positive. All HIV-positive women were on combined antiretroviral therapy (cART) during pregnancy, similar to all HIV-positive newborns who received ARTs for the first six weeks. We search for the influence of anthropometrical parameters (i.e., HC, BL, and BW), as well as clinical parameters (i.e., newborn sex and Apgar score) for both HIV-negative and HIV-positive newborns, along with the survival rate of HIV-positive newborns. Results: There were no differences in the sex of the newborns within either group, with more than 50% being boys. Similarly, the Apgar score did not show any statistically significant values between the two groups (i.e., p = 0.544 for HIV-positive newborns vs. p = 0.108 for HIV-negative newborns). Interestingly, our results showed that in Craiova, RC, there was a chance of 2.16 to find an HIV-negative newborn with an HC < 10th percentile and a 2.54 chance to find an HIV-negative newborn with a BL < 10th percentile compared to Constanta, RC, without any significant differences. On the contrary, Constanta, RC, represented a higher risk of death (i.e., 3.049 times, p = 0.0470) for HIV-positive newborns compared to Craiova, RC. Conclusions: Our results support the idea that follow-up of fetal growth restriction should be part of postnatal care in this high-risk population to improve adverse birth-related outcomes.

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Section: Discussionmentioning

confidence: 99%

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

et al. 2023

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“…Testing for viral hepatitis, a thorough medical history with attention to living conditions and behavior, and hepatotoxic drug use should be provided prior to calculating the FIB-4 score, since all these variables could strongly impact its value and therefore can provide a false prediction value. Second, ultrasound elastography, Fibroscan ® , or pathological examination [ 18 ] of the liver data are needed to establish whether an increased FIB-4 score is indeed associated with stiffness or fibrosis; therefore, more in-depth trials are needed to examine this [ 39 ]. Nonetheless, even with associated liver disease, and all the data we have available on SARS-CoV-2 regarding liver involvement, we can easily say that onset or progression of liver disease represents a risk factor for developing higher degrees of disease severity.…”

Section: Discussionmentioning

confidence: 99%

Liver Function Tests and FIB-4 Score as Predictors of Severity in COVID-19 Patients from the South-West of Romania

Kamal

Dumitrescu

Mita

et al. 2022

Life

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Background: The coronavirus disease 2019 pandemic (COVID-19) is the most important global health crisis to date. In this study, we performed an analysis to find the association between liver damage, FIB-4 score and the severity of COVID-19 disease. Methods: We included a total of 580 patients that tested positive for SARS-CoV-2 infection and were hospitalized. No patient included had any known history of liver disease. Liver function tests were performed, and FIB-4 score was calculated in order to assess their involvement in the disease progression. Results: More than half of the patients had elevated liver function tests. Age, high body mass index, associated heart disease and diabetes were associated with poor outcome. Corticosteroids, antibiotics, and anticoagulants strongly correlated with liver injuries. Liver impairment and injury, as well as a FIB-4 score higher than 3.5, also correlated with higher degrees of disease severity. Conclusion: Liver injury and elevated FIB-4 score were associated with poor clinical outcome and disease severity, as well as being a valuable tool to predict COVID-19-related mortality.

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“…As seen in other complex medical cases, a multidisciplinary approach is an important factor for improving survivability [ 16 ]. For the present case, cooperation between specialists (infectious diseases, genetics, internal medicine, dermatology, and oncology) was the key factor for successful management of the patient.…”

Section: Discussionmentioning

confidence: 99%

Persistent RNA SARS-CoV-2 Detection in a HIV-Infected Patient

et al. 2022

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The aim of this paper is to present a case of COVID-19 in a newly diagnosed HIV-infected, severely immunodepressed patient with a long persistence of positive RT-PCR for RNA SARS-CoV-2. Indirect data suggests that viable virus persisted for a long time in the absence of an adequate defense of the host. Improved immunity after starting antiretroviral treatment was not associated with an increased inflammatory reaction as regarding the infection due to the coronavirus and, apparently, was the main factor to control the infection. Remdesivir used to combat the SARS-CoV-2 infection had no immediate effect on the recorded cycle-threshold.

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Influence of multidisciplinary therapeutic approach on fibromyalgia patients

Cited by 13 publications

References 28 publications

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women

Liver Function Tests and FIB-4 Score as Predictors of Severity in COVID-19 Patients from the South-West of Romania

Persistent RNA SARS-CoV-2 Detection in a HIV-Infected Patient

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