To address knowledge gaps around enhanced efficiency urea fertilizer efficacy for nitrogen (N) management, a study was designed to improve integrated nutrient management systems for western Canadian winter wheat producers. Three factors were included in Experiment 1: (i) urea type [urea, urea + urease inhibitor—Agrotain®; urea + urease and nitrification inhibitor—SuperU®, polymer-coated urea—Environmentally Smart Nitrogen® (ESN®), and urea ammonium nitrate (UAN)], (ii) application method (side-band vs. spring-broadcast vs. 50% side-band: 50% spring-broadcast), and (iii) cultivar (AC Radiant hard red winter wheat vs. CDC Ptarmigan soft white winter wheat). The Agrotain® and CDC Ptarmigan treatments were removed in Experiment 2 to allow for additional application methods: (i) fall side-band, (ii) 50% side-band — 50% late fall broadcast, (iii) 50% side-band — 50% early spring broadcast, (iv) 50% side-band — 50% mid-spring broadcast, and (v) 50% side-band — 50% late spring broadcast. CDC Ptarmigan produced superior grain yield and N utilization over AC Radiant. Grain yield and protein content were influenced by N form and application method. Split applications of N usually provided the maximum yield and protein, particularly with Agrotain® or SuperU®. An exception to the poor fall-application results was the SuperU® treatments, which produced similar yield to the highest-yielding treatments. The results suggest that split applications of N might be most efficient for yield and protein optimization when combined with an enhanced efficiency urea product, particularly with urease or urease + nitrification inhibitors, and if the majority of N is applied in spring.