Influence of NaCl Concentrations on Coagulation, Temperature, and Electrical Conductivity Using a Perfusion Radiofrequency Ablation System: An Ex Vivo Experimental Study

Aubé, Christophe; Schmidt, Diethard; Brieger, J.; Schenk, Martin; Kroeber, Stefan; Vielle, Bruno; Claussen, Claus D.; Goldberg, S. Nahum; Pereira, Philippe L.

doi:10.1007/s00270-006-0091-y

Cited by 13 publications

(5 citation statements)

References 33 publications

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“…On the other hand, the number of oscillating ions when using 5% HCl and 10% HCl should have been lower. It may be that when 10% HCl was used, the impact of the relatively higher power output outweighed that of the lower conductivity, resulting in an overall higher amount of energy deposition and ablation volumes with 10% HCl [26].…”

Section: Discussionmentioning

confidence: 99%

Safety and effect on ablation size of hydrochloric acid-perfused radiofrequency ablation in animal livers

Zhang

Huang

et al. 2018

International Journal of Hyperthermia

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Section: Discussionmentioning

confidence: 99%

Safety and effect on ablation size of hydrochloric acid-perfused radiofrequency ablation in animal livers

Zhang

Huang

et al. 2018

International Journal of Hyperthermia

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“…If we consider values for non-infused liver np ¼ 0.148 Siemenes/metre [11] and 20% ¼ 4 S/m [12], and we consider the infusion point at, r ¼ 3.0 mm, i.e. 1.5 mm away from the electrode surface, the time-spatial variation of the electrical conductivity due to saline-infusion is represented in Figure 3, in which we used Equations 4 and 5 but kept T ðr, tÞ above the value of the nonsaline-perfused tissue (0.148 S/m).…”

Section: Theoretical Modellingmentioning

confidence: 99%

Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline:In vivostudy and preliminary computer modeling

Romero‐Méndez

Tobajas

Burdı́o

et al. 2012

International Journal of Hyperthermia

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“…Tissue-specific properties are related to the organ and tumor involved, they affect the efficacy of ablation in achieving local tumor control [2,3] and they cannot be modified by the operator [4,5].…”

Section: Introductionmentioning

confidence: 99%

Clinical Impact of a Protocol Involving Cone-Beam CT (CBCT), Fusion Imaging and Ablation Volume Prediction in Percutaneous Image-Guided Microwave Ablation in Patients with Hepatocellular Carcinoma Unsuitable for Standard Ultrasound (US) Guidance

Biondetti,

Ierardi,

Casiraghi

et al. 2023

JCM

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Purpose: to evaluate the clinical impact of a protocol for the image-guided percutaneous microwave ablation (MWA) of hepatocellular carcinoma (HCC) that includes cone-beam computed tomography (CBCT), fusion imaging and ablation volume prediction in patients with hepatocellular carcinoma unsuitable for standard ultrasound (US) guidance. Materials and Methods: this study included all patients with HCC treated with MWA between January 2021 and June 2022 in a tertiary institution. Patients were divided into two groups: Group A, treated following the protocol, and Group B, treated with standard ultrasound (US) guidance. Follow-up images were reviewed to assess residual disease (RD), local tumor progression (LTP) and intrahepatic distant recurrence (IDR). Ablation response at 1 month was also evaluated according to mRECIST. Baseline variables and outcomes were compared between the groups. For 1-month RD, propensity score weighting (PSW) was performed. Results: 80 consecutive patients with 101 HCCs treated with MWA were divided into two groups. Group A had 41 HCCs in 37 patients, and Group B had 60 HCCs in 43 patients. Among all baseline variables, the groups differed regarding their age (mean of 72 years in Group A and 64 years in Group B, respectively), new vs. residual tumor rates (48% Group A vs. 25% Group B, p < 0.05) and number of subcapsular tumors (56.7% Group B vs. 31.7% Group A, p < 0.05) and perivascular tumors (51.7% Group B vs. 17.1% Group A, p < 0.05). The protocol led to repositioning the antenna in 49% of cases. There was a significant difference in 1-month local response between the groups measured as the RD rate and mRECIST outcomes. LTP rates at 3 and 6 months, and IDR rates at 1, 3 and 6 months, showed no significant differences. Among all variables, logistic regression after PSW demonstrated a protective effect of the protocol against 1-month RD. Conclusions: The use of CBCT, fusion imaging and ablation volume prediction during percutaneous MWA of HCCs provided a better 1-month tumor local control. Further studies with a larger population and longer follow-up are needed.

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Influence of NaCl Concentrations on Coagulation, Temperature, and Electrical Conductivity Using a Perfusion Radiofrequency Ablation System: An Ex Vivo Experimental Study

Cited by 13 publications

References 33 publications

Safety and effect on ablation size of hydrochloric acid-perfused radiofrequency ablation in animal livers

Safety and effect on ablation size of hydrochloric acid-perfused radiofrequency ablation in animal livers

Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline:In vivostudy and preliminary computer modeling

Clinical Impact of a Protocol Involving Cone-Beam CT (CBCT), Fusion Imaging and Ablation Volume Prediction in Percutaneous Image-Guided Microwave Ablation in Patients with Hepatocellular Carcinoma Unsuitable for Standard Ultrasound (US) Guidance

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