Influence of nanoparticles of platinum on chicken embryo development and brain morphology

Prasek, Marta; Sawosz, Ewa; Jaworski, Sławomir; Grodzik, Marta; Ostaszewska, Teresa; Kamaszewski, Maciej; Wierzbicki, Mateusz; Chwalibog, A.

doi:10.1186/1556-276x-8-251

Cited by 58 publications

(53 citation statements)

References 36 publications

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“…On the other hand, some researchers showed that the numbers of nonviable fetuses was significantly increased in dams treated to a single oral dose of 10 mg/kg/B.wt AgNPs not higher doses, this due to facilitation of aggregation AgNPs at higher concentration in gut and preventing internalization via the gastrointestinal tract and so reducing fetotoxicity at higher doses, this result agree with [22]. Other study showed many pathological changes in the brain structure in chicken embryos treated with platinum nanoparticles NP-Pt, showing a moderate degradation of the cerebellar molecular layer, loss in neural cells in the cerebellum cortex, and astrocytosis [23]. In this study, we observed that AgNPs when administration to pregnant rats at concentration (2, 20mg/kg/B.wt) not have seen mortality in dams, while, other study found that administration of 20 mg silver ion led to the death of more than half pregnant rats in group after 1 ml injection, due to that silver nanoparticle is less toxicity than silver ions [24].…”

Section: Discussionsupporting

confidence: 72%

Effect of maternal exposure of silver nanoparticles on the histogenesis of cerebellum in post-implantation of albino rats embryos

Ali

Salih

2018

ijs

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The central nervous system is the most important system and is very sensitive to any accidental infection during ontogenesis; it includes brain and spinal cord. The cerebellum is the second largest part of the brain after cerebrum and it's very sensitive to the abnormal changes during the embryological development. This study was designed to investigate the effect of the maternal exposure of selected concentrations of suspension of nanoparticles on the ontogenesis of the rat cerebellum after embryos implanted in uterus.A total of 60 female pregnant rats were divided in to three groups, each contains 20 females. Group1 (G1) was treated orally with 2mg/kg /body weight (b. wt) of suspension of silver nanoparticles (Ag NPs). While group 2 (G2) was treated with 20mg/kg/b. wt of AgNPs after implantation from 7 th day of pregnancy until delivery at day 21 st, for 15 day. And group3 (G3) was considered as control whose received Distal water (D.W) only. We had selected the following embryonic day for treatment (ED12,15, 18 and 21). The histological results showed a defect in the ontogenesis of the cerebellum cortex layers of embryos, through lack of density of external granular layer, as well as degeneration and dispersion of the glial cells in the internal granular layer of cerebellar cortex, in addition to less distribution of cells in the molecular layer due to the ability of AgNPs to pas the placenta and blood brain barrier (BBB) to the embryo's brain after female exposure to the AgNPs during pregnancy. AgNPs at low concentration 2mg/kg/day and higher concentration 20mg/kg/day can produce many histological toxicity to the embryo's hindbrain and cerebellum when administrated to the dams during pregnancy period. ISSN: 0067-2904Ali and SalihIraqi Journal of Science, 2018, Vol. 59, No.1B, pp: 271-277 IntroductionThe central nervous system (CNS) is a very critical and sensitive system during embryogenesis; it is protected by blood-brain barrier (BBB) which, consequently, hampers the success of current therapies by blocking drugs and other chemical and nanoparticles access to brain [1]. BBB is a layer of endothelial cells very tightly bound to each other (by tight junctions, TJ) that block the transport of drugs and many nanoparticles from blood to brain [2]. The cerebellum is the second largest part of the brain therefore, the cerebellum is an ideal useful model for studying many aspects of neural development, because each stage of development has a distinct morphology and special histological features with different types of cells [3]. The volume of the human cerebellum increases ~10× between 20 and 40 weeks of gestation, with the surface area increasing much more due to the formation of folia and lobules [4], [5].Physiologically, the cerebellum is considered as the key regulator of the central nervous system in the mammals, because it regulates the motor and sensory activities such as attention, balance, languages and some emotional functions like fear and pleasure [6], [7] Because rapid development of nan...

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Section: Discussionsupporting

confidence: 72%

Effect of maternal exposure of silver nanoparticles on the histogenesis of cerebellum in post-implantation of albino rats embryos

Ali

Salih

2018

ijs

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“…Similarly, platinum NP also did not affect the growth and development of chicken embryos [Prasek et al, 2013]. Nevertheless, NP induced apoptosis ( table 3 ) and decreased the number of proliferating cells in the brain tissue [Prasek et al, 2013].…”

Section: Embryonic Toxicity Of Np In Animal Models: Avian Embryosmentioning

confidence: 89%

“…Nevertheless, NP induced apoptosis ( table 3 ) and decreased the number of proliferating cells in the brain tissue [Prasek et al, 2013]. On the other hand, concentrations of platinum NP were lower in chicken embryos in comparison to zebrafish [Asharani et al, 2011].…”

Section: Embryonic Toxicity Of Np In Animal Models: Avian Embryosmentioning

confidence: 98%

Embryonic Toxicity of Nanoparticles

Celá

Veselá

Matalová

et al. 2014

Cells Tissues Organs

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Applications of nanoparticles (NP) in medicine, industry and other branches of human activities undoubtedly contribute to technology development and well-being. However, as NP are very small units in a wide range of materials, there is a lack of information related to possible side effects potentially affecting the health of organisms. There is increasing experimental interest in the determination of environmental effects on humans exposed to NP. Most such experimental studies focus on adult populations or adult experimental animals. However, embryos can be more sensitive to pollutants and environmental impacts in some species. Therefore, some investigations dealing particularly with the effects of NP on embryonic development have appeared recently and this issue is becoming of great concern. The aim of this review is to summarize the knowledge on the effects of various nanomaterials on embryonic development. A comprehensive collection of significant experimental nanotoxicity data is presented, which also indicate how the toxic effect of NP can be mediated and modulated with respect to possible effective protection strategies.

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“…NP made of noble metals have been also used in brain delivery for theranostic purposes [317] , [325][326][327]. Neurotoxicity of silver in the brain has already been reported after systemic, intracerebral and intranasal administration [321,325,328,329].…”

Section: In Vivo Toxicity Of Nanomaterialsmentioning

confidence: 99%

Diagnostic and Therapeutic Uses of Nanomaterials in the Brain

Garbayo¹,

Mendoza²,

Blanco-Prieto

2014

CMC

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Nanomedicine has recently emerged as an exciting tool able to improve the early diagnosis and treatment of a variety of intractable or age-related brain disorders. The most relevant properties of nanomaterials are that they can be engineered in such a way that they can cross the blood brain barrier, with the final aim of targeting specific cells and molecules and to act as vehicles for drugs. Potentially beneficial properties of nanotherapeutics derived from its unique characteristics include improved efficacy, safety, sensitivity and personalization compared to conventional medicines.In this review, recent advances in available nanostructures and nanomaterials for brain applications will be described. Then, the latest nanotechnological applications for the treatment and diagnosis of neurological disorders, mainly brain tumors and neurodegenerative diseases, will be reviewed. Recent investigations of the neurotoxicity of the nanomaterial both in vitro and in vivo will be summarized. Finally, the ongoing challenges that have to be meet if new nanomedical products are to be put on the market will be discussed and some future directions will be outlined.

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Influence of nanoparticles of platinum on chicken embryo development and brain morphology

Cited by 58 publications

References 36 publications

Effect of maternal exposure of silver nanoparticles on the histogenesis of cerebellum in post-implantation of albino rats embryos

Effect of maternal exposure of silver nanoparticles on the histogenesis of cerebellum in post-implantation of albino rats embryos

Embryonic Toxicity of Nanoparticles

Diagnostic and Therapeutic Uses of Nanomaterials in the Brain

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