Influence of narrow‐band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis

Silva, S. H.; Guedes, Antônio Carlos Martins; Gontijo, Bernardo; Ramos, Andréa Machado Coelho; Carmo, Luiz Simeão do; Farias, Leiliane Martins; Nicoli, Jacques R.

doi:10.1111/j.1468-3083.2006.01748.x

Cited by 70 publications

(57 citation statements)

References 24 publications

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“…Previous studies have shown that more than 50-60% of Staph. aureus strains isolated from patients with AD are exotoxin-producing strains, which can secrete various exotoxins including SEA, SEB, SEC, SED and TSST-1 (Bunikowski et al 2000;Chen et al 2005;Silva et al 2006;Schlievert et al 2008;Nada et al 2012).…”

Section: Discussionmentioning

confidence: 99%

A diversity profile from the staphylococcal community on atopic dermatitis skin: a molecular approach

et al. 2013

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Aims: The aim of this study was to determine the biodiversity of the skin staphylococcal community from patients with atopic dermatitis (AD) and superantigen (SAg) detection from Staphylococcus aureus isolates. Methods and Results: In this study, we developed a novel multiplex PCR that allows the identification and discrimination of bacteria belonging to the Staphylococcus genus both Staph. aureus and coagulase-negative Staphylococcus À Staph. capitis, Staph. epidermidis, Staph. haemolyticus and Staph. hominis isolated from the skin of patients with AD. In addition, a multiplex PCR assay that allows the rapid screening of the 19 genes that encode staphylococcal enterotoxins (SEs), SE-like toxins and toxic shock syndrome toxin-1 was also performed and applied in Staph. aureus isolates. The microflora of the skin of patients with AD was dominated by Staph. aureus (69 isolates, 35Á6%) followed by Staph. epidermidis (59 isolates, 30Á4%) species. The SElM and SElN genes were the most frequently detected in our study (15 isolates, 71Á4%), followed by SEG and SElO (14 isolates, 66Á7%). Conclusions: Our molecular-based approach successfully identified the staphylococcal microflora that was relatively specific to patients with AD. Considering skin colonization and expression of virulence factors, the Staph. aureus may play a relevant role in AD pathophysiology. Significance and Impact of the Study: This ability to classify disease-related microbial species provides new insights into the relevance of those microbes in human disorders.

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Section: Discussionmentioning

confidence: 99%

A diversity profile from the staphylococcal community on atopic dermatitis skin: a molecular approach

et al. 2013

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“…Clearly, UVA1 irradiation seems to be superior to conventional UVA-UVB phototherapy in patients with severe AD 85,86 . Narrow-band UVB alone is also effective and its activity seems to be partially due to a decrease in the microbial colonization 87 .…”

Section: ) Phototherapymentioning

confidence: 99%

Atopic Dermatitis

2010

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“…7 Impetiginized atopic skin can even improve on UV exposure without antibacterial treatment. 8 Hence, the question arises how UV radiation, which is known to be immunosuppressive, does not generally worsen but sometimes even improves bacterial infections.…”

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confidence: 99%

UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo

Gläser

Navid

Schuller

et al. 2009

Journal of Allergy and Clinical Immunology

177

146

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Influence of narrow‐band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis

Abstract: The results of the present study show the beneficial effect of UVB phototherapy on AD and suggest that this may be attributable not only to reduction of skin surface bacteria but also to the suppression of superantigen production from S. aureus.

Cited by 70 publications

References 24 publications

A diversity profile from the staphylococcal community on atopic dermatitis skin: a molecular approach

A diversity profile from the staphylococcal community on atopic dermatitis skin: a molecular approach

Atopic Dermatitis

UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo

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