In the present study, groundwater suitability for domestic and irrigation purposes was analyzed in the alluvial aquifers of the Bist-Doab region of Punjab, India, using various indices such as WQI, WAWQI, MCDA, RSC, SAR, PI, %Na, KR, MH, PS, K, and Ka. Since it is difficult to assess the suitability of groundwater for irrigation based on various indices individually, a composite groundwater quality index for irrigation (CGQII) was used in the study which transforms nine indices to a single value for each sample. Results reveal that the groundwater of a few blocks was found unsuitable for domestic use due to chemical leaching from fertilizers, pesticides, and agricultural and industrial wastes. Whereas, the groundwater of mainly southwestern parts was found unsuitable for irrigation due to long-term water accumulation in aquifers and continuous use of sodium-ion-rich groundwater. The findings conclude that anthropogenic activities have played a significant role in making groundwater unfit for domestic and irrigation purposes in the study area. The present study also emphasizes continuous monitoring and evaluation of groundwater quality, which will help in strategic planning and management for the conservation of groundwater resources in the region.