The article proposes a method for determining the deformation modulus of fractured-block rock masses, weakened by mutually-orthogonal systems of cracks within the linear section (after the closure of cracks) of the deformation curve σ= f (ε). The values of normal - kn and tangential - ks stiffness are used as elastic characteristics of joints. It is shown that in such rocky structures it is impossible to apply the laws of mechanics of a solid elastic body to calculate their deformation characteristics, since the opening of interblock joints is observed when performing numerical experiments. The discrepancy between the results of numerical and analytical calculations is up to 40%. For these purposes, it is proposed to use the regression equation obtained on the basis of regression analysis based on the results of numerical modeling and the method of experiment planning. The presented equation allows, depending on three independent factors: the modulus of elasticity of the rock block - Eo, the rock quality designation index - RQD and the dip angles of systems of mutually orthogonal ioints – α, to determine the modulus of deformation ofthe rock mass.