Influence of novelty on locomotor hyperactivity after lesions of superior colliculus in rats

Dean, Paul; Pope, Sian G.; Redgrave, Peter

doi:10.1016/0166-4328(82)90055-9

Cited by 27 publications

(10 citation statements)

References 11 publications

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“…Collicular animals usually run faster than normals in runways Murison & Mayes 1980), which perhaps causes them to make premature, ballistic "approach errors" to incorrect discriminanda (Schneider 1969;Winterkorn 1975), especially when discriminanda are unexpectedly changed (Thinus- Blanc 1983). They are hyperactive in a head-dip apparatus (Dean, Pope, Redgrave & Donohoe 1980;Foreman 1983a), on initial placement in open arenas (Dean, Pope & Redgrave 1982;Marshall 1978;Pope & Dean 1979), in operant chambers (Capps & Stockwell, 1968), and in spatial mazes, when test intervals are as short as 2 minutes (Smith & Weldon 1976). They also swim faster than controls (Milner & Lines 1983).…”

Section: Motor Control and Behavioural Inhibition I Open Field Hypermentioning

confidence: 99%

“…Clearly, then, hippocampals are not totally nonexploratory as suggested by O' Keefe and Nadel (1978). Moreover, whereas in collicular rats activity level may be related to extent and degree of inattentiveness (Dean et al 1982;Foreman 1983a), for hippocampals Kohler (1976) has noted that "increased activity . .…”

Section: Motor Control and Behavioural Inhibition II Activity And Atmentioning

confidence: 99%

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Relationships between the superior colliculus and hippocampus: Neural and behavioral considerations

Foreman

Stevens

1987

Behav Brain Sci

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Theories of superior collicular and hippocampal function have remarkable similarities. Both structures have been repeatedly implicated in spatial and attentional behaviour and in inhibitory control of locomotion. Moreover, they share certain electrophysiological properties in their single unit responses and in the synchronous appearance and disappearance of slow wave activity. Both are phylogenetically old and the colliculus projects strongly to brainstem nuclei instrumental in the generation of theta rhythm in the hippocampal EECOn the other hand, close inspection of behavioural and electrophysiological data reveals disparities. In particular, hippocampal processing mainly concerns stimulus ambiguity, contextual significance, and spatial relations or other subtle, higher order characteristics. This requires the use of largely preprocessed sensory information and mediation of poststimulus investigation. Although collicular activity must also be integrated with that of “higher” centres (probably to a varying degree, depending on the nature of stimuli being processed and the task requirements), its primary role in attention is more “peripheral” and specific in controlling orienting/localisation via eye and body movements toward egocentrically labelled spatial positions. In addition, the colliculus may exert a nonspecific influence in alerting higher centres to the imminence of information potentially worthy of focal attention. Nevertheless, it is noteworthy that collicular and hippocampal lesions produce deficits on similar tasks, although the type of deficit is usually different (often opposite) in each case. Functional overlap between hippocampus and colliculus (i.e., strategically synchronised or mutually interdependent activity) is virtually certain vis-à-vis stimulus sampling, for example in the acquisition of information via vibrissal movements and visual scanning. In addition, insofar as stimulus significance is a factor in collicular orienting mechanisms, the hippocampus — cingulate – cortex — colliculus pathway may play a significant role, modulating collicular responsiveness and thus ensuring an attentional strategy appropriate to current requirements (stimulus familiarity, stage of learning). A tentative “reciprocal loop” model is proposed which bridges physiological and behavioural levels of analysis and which would account for the observed degree and nature of functional overlap between the superior colliculus and hippocampus.

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Section: Motor Control and Behavioural Inhibition I Open Field Hypermentioning

confidence: 99%

Section: Motor Control and Behavioural Inhibition II Activity And Atmentioning

confidence: 99%

Relationships between the superior colliculus and hippocampus: Neural and behavioral considerations

Foreman

Stevens

1987

Behav Brain Sci

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“…When an unfamiliar conspecific is introduced in the environment, the experimental mouse typically stops the ongoing action to re-orient its attention towards the stimulus, right before or while initiating the interaction. The SC is highly involved in attention and orienting response toward novel and salient stimuli (16) (17) (18) and our previous results with the fiber photometry suggested that the SC – VTA neuron activity occurs before the interaction. Thereby, to capture this attentional shift during social exposure, we calculated in ChR2 and Jaws-expressing mice the head orientation (ω) as the angle formed between the vector determined from the body center to the nose of the experimental mouse, to the juvenile body center ( Figure 3H ).…”

Section: Resultsmentioning

confidence: 90%

Section: Sc -Vta Pathway Bidirectionally Controls Social Interactionmentioning

confidence: 76%

“…Several studies have provided evidence that a subcortical structure in the midbrain, the Superior Colliculus (SC), is a source of short-latency visual inputs to midbrain DA neurons (11 , 12, 13 , 14) . SC is an evolutionary conserved midbrain structure that is activated by biological salient stimuli independently of their valence (15) and plays a key role in controlling orientation and spatial attention (16, , 17, 18) . Recently, it has been shown that SC sends excitatory projections onto VTA GABA neurons to control defensive behavior while SC inputs onto VTA DA neurons might contribute to reinforcement learning (19) .…”

Section: Introductionmentioning

confidence: 99%

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Superior Colliculus to VTA pathway controls orienting response to conspecific stimuli

Prévost-Solié¹,

Contestabile²,

Espinosa³

et al. 2019

Preprint

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Social behaviors are highly important in mammals as conspecific interaction impairments are symptomatic of neuropsychiatric diseases. Several neural circuit mechanisms underlying the regulation of social behaviors have been described. Among them, dopamine (DA) neurons in the Ventral Tegmental Area (VTA) have been implicated in modulating the rewarding properties of conspecific interaction. However, how DA neurons receive information related to conspecifics is still an open question. In this study, we identified that Superior Colliculus (SC) neurons projecting to the VTA decrease their activity during conspecific interaction. Using optogenetic approaches, we demonstrated that SC – VTA pathway controls orientation towards unfamiliar conspecifics and regulates social interaction while Anterior Cortex (AC) to VTA pathway promotes conspecific interaction without affecting orienting behaviors towards the conspecific. Moreover, we show that contrary to AC pathway, SC projects onto VTA DA neurons that send inputs to dorsolateral striatum (DLS). Photostimulation of VTA to DLS pathway decreases interaction, mimicking SC to VTA stimulation. Our work not only delineates a previously unknown role of SC–VTA–DLS pathway in controlling orienting behavior during conspecific interaction, but also supports the hypothesis that different VTA DA neurons subpopulations play a specific role in social behavior.One sentence summaryDistinct ventral tegmental area dopaminergic pathways encode for complementary aspects of social behavior in mice.

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The effects of superior colliculus lesions in hamsters: Feature detection versus spatial localization

Thinus‐Blanc

Scardigli

Buhot

1991

Physiology & Behavior

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Influence of novelty on locomotor hyperactivity after lesions of superior colliculus in rats

Cited by 27 publications

References 11 publications

Relationships between the superior colliculus and hippocampus: Neural and behavioral considerations

Relationships between the superior colliculus and hippocampus: Neural and behavioral considerations

Superior Colliculus to VTA pathway controls orienting response to conspecific stimuli

The effects of superior colliculus lesions in hamsters: Feature detection versus spatial localization

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