Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans

Eom, Sang‐Yong; Zhang, Yan Wei; Kim, Sung Hoon; Choe, Kyu Ok; Lee, Kye Young; Park, Jung-Duck; Hong, Yun–Chul; Kim, Yong‐Dae; Kang, Jeong Woo; Kim, Heon

doi:10.1007/s10552-008-9225-7

Cited by 38 publications

(29 citation statements)

References 36 publications

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“…Similarly, the NQO1 rs1800566 CT and TT genotypes combined were significantly associated with an increased risk of lung cancer (OR=1.42; 95% CI=1.01-2.01). However, it is biologically plausible that the NQO1 polymorphisms affect lung cancer risk (20), as NQO1 has anti-carcinogenic activities, even though an association between NQO1 rs1800566 and lung cancer risk has not yet been confirmed. Notably, a recent meta-analysis study identified no significant association with lung cancer overall (35); however, stratified analysis by histology revealed that the TT and CT genotypes combined were marginally associated with an increased risk of SCC (OR for the TT and CT genotypes combined vs. the CC genotype=1.20; 95% CI=1.00-1.43; P=0.05).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the metabolism of carcinogens, accumulating evidence suggests that NQO1 may lead to lung cancer development by inflammation (20). A previous study demonstrated that inflammatory cytokines, including IL1β and TNFα, suppress NQO1 activity (38).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, this enzyme is considered to be involved in metabolic activation and the detoxification of carcinogens. It is also plausible that NQO1 is involved in susceptibility to tobacco-associated lung carcinogenesis (20). Additionally, accumulating evidence demonstrates that NQO1 serves a role in inflammatory activities, including anti-inflammatory processes and the scavenging of superoxide anion radicals (21,22).…”

Section: Introductionmentioning

confidence: 99%

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Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in inflammation and the risk of lung cancer: A case-control study in Japan

et al. 2017

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Abstract.Chronic inflammation serves an important role in lung carcinogenesis, thus genetic polymorphisms involved in this pathway may affect the risk of lung cancer. The present case-control study focused on the association between lung cancer risk and genetic polymorphisms involved in inflammatory pathways. The study comprised 462 lung cancer cases and 379 controls from Japan. The roles of interleukin 8 (IL8) rs4073, nuclear factor kappa B (NFκB) rs28362491, cytochrome b-245, alpha polypeptide (CYBA) rs4673, NAD(P) H dehydrogenase, quinone 1 (NQO1) rs1800566, nitric oxide synthase 2 and inducible (NOS2) rs2297518 polymorphisms in lung carcinogenesis were investigated. An unconditional logistic model was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between the genetic polymorphisms and lung cancer risk. The multiplicative and additive [relative excess risk due to interaction, attributable proportion due to interaction (AP) and synergy index (SI)] interactions with cigarette smoking were also determined. A significant association was revealed between the TT genotype of NQO1 rs1800566 and an increased risk of lung cancer (OR=1.78; 95% CI=1.14-2.79). The additive interaction evaluations between CYBA rs4673 (AP= 0.50, SI=2.66,) and smoking were also statistically significant. NQO1 rs1800566 was significantly associated with lung cancer risk and smoking may influence the association between CYBA rs4673 and the risk of lung cancer. Additional studies with larger control and case populations are warranted in order to confirm the CYBA rs4673-smoking association suggested by the present study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in inflammation and the risk of lung cancer: A case-control study in Japan

et al. 2017

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“…On the other hand, CYP2E1 c1/c1 genotype was associated with a significant increased risk for lung cancer in smokers with alcohol drinking (49). The induction of CYP2E1 is influenced by alcohol metabolism and this effect participates in the metabolic activation of various carcinogens such as N-nitrosodimethylamine (5,50).…”

Section: New Candidates Of Susceptible Genesmentioning

confidence: 99%

Additional candidates to conventional genes susceptible for lung cancer and changing trend in Japan (Review)

Okazaki

Sugita²,

Matsuki³

et al. 2010

Oncol Rep

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“…Polymorphisms of CYP2C9 can effect the risk of bleeding complications (19) and the response to the antihypertensive effects of losartan (20). Polymorphisms of CYP2E1, together with cumulative smoking and alcohol consumption, and polymorphisms of NQO1 and ALDH2 have been synergistically associated with lung cancer in Koreans (21). Polymorphisms of CYP7A1 have been associated with baseline low-density lipoprotein (LDL) and HDL cholesterol levels and risk of coronary artery disease (22).…”

Section: Introductionmentioning

confidence: 99%

Association between cytochrome P450 promoter polymorphisms and ischemic stroke

Kim

Yim

Lee

2011

Experimental and Therapeutic Medicine

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Abstract. The human cytochrome P450 (CYP) superfamily includes at least 57 genes that encode enzymes with diverse metabolic and biosynthetic functions. This study was conducted in order to investigate the associations between polymorphisms in CYP superfamily genes (CYP11B2, CYP17A1, CYP2B6, CYP2C9, CYP2E1 and CYP7A1) and ischemic stroke (IS). Six single nucleotide polymorphisms (SNPs) of CYP superfamily genes were selected and genotyped by direct sequencing in 121 patients with IS and 321 control subjects. The genetic data were analyzed using SNPStats and SPSS 18.0. Multiple logistic regression models (codominant 1, codominant 2, dominant, recessive and log-additive) were used to evaluate odds ratios (ORs), 95% confidence intervals (CIs) and p-values. The rs179998 SNP of CYP11B2 was significantly associated with IS (p=0.0336 in a log-additive model). The rs3813867 SNP of CYP2E1 was significantly associated with smoking in IS (p=0.0336 in a log-additive model). The rs1799998 SNP of CYP11B2 and rs3808607 of CYP7A1 were related to diabetes mellitus in IS (p<0.05). CYP11B2, CYP2E1 and CYP7A1 SNPs were associated with IS in the population studied. Further study is required to confirm these associations and to determine their biological significance.

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Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans

Cited by 38 publications

References 36 publications

Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in inflammation and the risk of lung cancer: A case-control study in Japan

Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in inflammation and the risk of lung cancer: A case-control study in Japan

Additional candidates to conventional genes susceptible for lung cancer and changing trend in Japan (Review)

Association between cytochrome P450 promoter polymorphisms and ischemic stroke

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