Influence of Nutrition on Liver Regeneration

Saint-Aubert, B.; Astre, C.; Andriguetto, P. C.; Yakoun, M; Joyeux, H

doi:10.1159/000408152

Cited by 6 publications

(3 citation statements)

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“…Under ether anesthesia, a midline laparotomy was performed. Partial hepatectomy was then carried out by aseptic extirpation of the median and left lateral lobes, according to the procedure of 6, 24, 48, and 72 hours after partial hepatectomy in each rat group. HG, high glucose; C, control; HF, high fat; S, sham operation; a, HG us HF, p < .01; b, HG us C, p < .01; c, HF us C, p < .01).…”

Section: Surgical Proceduresmentioning

confidence: 99%

Energy Substrate for Liver Regeneration After Partial Hepatectomy in Rats: Effects of Glucose vs Fat

Lai¹,

Chen²,

Chen³

1992

J Parenter Enteral Nutr

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This study evaluated the effects of glucose or fat on liver regeneration after partial hepatectomy in rats. Partial hepatectomy with resection of the median and left lateral lobes (67.31%) was performed on three rat groups. Two groups were infused with high-glucose (HG) or high-fat (HF) solutions intravenously 2 days before surgery. The control (C) group was allowed to eat instead of receiving intravenous infusions. Another group with sham operation only was also allowed to eat. Rats were killed 6, 24, 48, or 72 hours after the operation. Remnant liver weight, DNA synthetic rate, DNA content, and mitotic index were chosen as comparing indicators. Blood glucose, serum free fatty acid (FFA), total ketone bodies, and ketone body ratio were measured. Transmission electron microscopy was also used to observe the remnant liver. The results showed that the HG rat group had a better regenerative condition than did the HF rat group (p less than .01). Glucose is the predominant energy substrate when enough is offered during the immediate posthepatectomy phase. FFA utilization occurred only very early after partial hepatectomy, and it was remarkable in the control group, moderate in the HF group, and low in the HG group. Shifting of the energy substrate to FFA occurred only when glucose was not available for utilization. The disappearance and reappearance of glycogen, and accumulation of fat in cytoplasm as shown by transmission electron microscope pictures support this conclusion.

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Section: Surgical Proceduresmentioning

confidence: 99%

Energy Substrate for Liver Regeneration After Partial Hepatectomy in Rats: Effects of Glucose vs Fat

Lai¹,

Chen²,

Chen³

1992

J Parenter Enteral Nutr

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“…All patients had primary or metastatic liver neoplams. Patients were evaluated for possible liver resection by physical examination, laboratory data, and routine pre-operative abdom-Inal imaging studies including conventional ultrasound (us) and COmputed tomography (CT) [2].…”

Section: To the Editormentioning

confidence: 99%

To the editor

et al. 1992

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“…The administration of branched‐chain amino acids (BCAA) has been reported to improve liver regeneration after partial resection . In our own recent studies, this nutritional support was found to reduce the incidence of sepsis and endotoxemia after liver resection in cirrhotic patients 4.…”

Section: Introductionmentioning

confidence: 99%

Administration of branched chain amino acids prevents bacterial translocation after liver resection in the cirrhotic rat

Higashiguchi

Ito

Kitagawa

et al. 1996

J Hep Bil Pancr Surg

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Abstract:After major liver resection, bacterial infectious complications, including sepsis and endotoxemia, can be at least in part, attributed to translocation of enteric bacteria and endotoxin. We evaluated the effectiveness of the enteral and parenteral administration of branched-chain amino acids (BCAA) in preventing bacterial translocation after 70% liver resection in rats with thioacetamide-induced-cirrhosis. Bacterial translocation after hepatectomy was induced by a disturbance of protein metabolism in intestinal epithelial cells. However, the administration of BCAA, particularly via the enteral route, improved amino acid metabolism in the gut and stimulated the synthesis of nonsecreted protein and the proliferation of crypt cells, thereby preventing bacterial translocation after liver resection. Improvement in this cascade of metabolic reactions is believed to have been responsible for the improved outcome after extensive resection of the cirrhotic liver.

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Influence of Nutrition on Liver Regeneration

Cited by 6 publications

References 0 publications

Energy Substrate for Liver Regeneration After Partial Hepatectomy in Rats: Effects of Glucose vs Fat

Energy Substrate for Liver Regeneration After Partial Hepatectomy in Rats: Effects of Glucose vs Fat

To the editor

Administration of branched chain amino acids prevents bacterial translocation after liver resection in the cirrhotic rat

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