Influence of Nutritionally Induced Anaemia on the Oestrous Cycle of Mice

Rathika, V.; Archunan, Govindaraju; Raghuraman, Vasudevan Unnithan

doi:10.1007/s005800070014

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“…Hb less than 9 or 10 g/100 ml of blood suggests anaemia (Fisher 1980). Anaemia also influences oestrous cycle of mice by decreasing the number of normal cycles or increasing the number of prolonged oestrous cycles (Rathika et al 2000). In this study, the following questions were therefore addressed: Is there an alternative cause of SA in the absence of hormonal, ovarian and uterine dysfunction?…”

Section: Introductionmentioning

confidence: 99%

Secondary Amenorrhoea: Nutritional Anaemia a Cause or Reason

Raghuraman

Rathika

2001

Comparative Haematology International

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Nutritional deficiencies, menstrual irregularities and anaemia are commonly noticed among women in our population. To understand if nutritional anaemia could also be a contributing factor for secondary amenorrhoea (SA) in addition to various other factors known, a total of 50 patients, married and unmarried with SA of 3 months to 24 months duration were investigated for thyroid (T 3 , T 4 and thyroid-stimulating hormone (TSH), gonadotrophic hormones (luteinising hormone (LH), follicle-stimulating hormone (FSH) and prolactin), a few haematological parameters and serum protein, iron and total iron binding capacity (TIBC) levels. In these patients, uterine and ovarian factors were ruled out. Among these patients, thyroid dysfunction was seen in 46% of cases, whereas only 10% had LH, FSH and prolactin variations. Haematological studies revealed that the majority of these patients exhibited moderate to severe anaemia. From the estimation of serum protein, serum iron and TIBC levels the type of anaemia was found to be protein-iron deficiency anaemia (nutritional anaemia). These results conclude that hormonal factors apart from uterine and ovarian anamolies, need not be the main causes for SA and it was found that in the majority of the cases tested, SA was due to nutrition-related anaemia. In a few patients, it was noteworthy that the presence of anaemia along with thyroid disorder caused early onset of SA which was also of longer duration.

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Section: Introductionmentioning

confidence: 99%