Influence of Obesity on Drug Disposition and Effect

Boullata, Joseph I.

doi:10.1007/978-1-59259-781-9_6

Cited by 2 publications

(2 citation statements)

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“…When an obese individual's total body weight-normalized value for distribution volume when total body clearance approach or exceed those in nonobese individuals, use of total body weight is recommended for calculating loading and maintenance doses. 22 When these values are lower in obese individuals, an adjusted or lean body weight approach is recommended for dosing. 22,23 The influence of nutritional status has not yet been evaluated for the other six agents reviewed.…”

Section: Influence Of Nutritional Statusmentioning

confidence: 99%

“…22 When these values are lower in obese individuals, an adjusted or lean body weight approach is recommended for dosing. 22,23 The influence of nutritional status has not yet been evaluated for the other six agents reviewed. Even the influence of age, ethnicity, and organ dysfunction have yet to be evaluated for bortezomib.…”

Section: Influence Of Nutritional Statusmentioning

confidence: 99%

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An Approach to Evaluating Drug-Nutrient Interactions

Santos

Boullata

2005

Pharmacotherapy

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Although the significance of interactions between drugs is widely appreciated, little attention has been given to interactions between drugs and nutrients. Pharmacists are challenged to remember documented interactions involving available drugs, and they face the possibility that each newly approved therapeutic agent may be involved not only in unrecognized drug-drug interactions but in drug-nutrient interactions as well. A more consistent approach to evaluating drug-nutrient interactions is needed. The approach must be systematic in order to assess the influence of nutritional status, food, or specific nutrients on a drug's pharmacokinetics and pharmacodynamics, as well as the influence of a drug on overall nutritional status or on the status of a specific nutrient. We provide such a process, using several recently approved drugs as working examples. Risk factors and clinical relevance are described, with distinctions made between documented and potential interactions. Application of this process by the pharmacist to any drug will help increase their expertise. Furthermore, full consideration by pharmacists of all possible interactions of the drug regimens used in practice can allow for improved patient care.

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Section: Influence Of Nutritional Statusmentioning

confidence: 99%