Influence of Obstructive Sleep Apnea on Ischemia-Modified Albumin Levels and Carotid Intima-Media Thickness

Abstract

Obstructive sleep apnea (OSA) is associated with an increased risk of atherosclerosis. Carotid intima-media thickness (CIMT) is strongly associated with the presence of significant risk factors for cardiovascular disturbances. A disturbance in the oxidative/antioxidative balance is involved in the pathogenesis of OSA and cardiovascular diseases. Ischemia-modified albumin (IMA) is suggested as a novel marker of oxidative stress; IMA can be defined as decreased binding of transitional metal ions to serum albumin in oxidative status. The purpose of this research was to evaluate the influence of OSA on IMA levels and CIMT. In total, 61 individuals with OSA with no comorbidities and 24 healthy controls with a similar body mass index and age were enrolled in this study. Serum levels of IMA, CIMT (estimated radiologically), and polysomnographic parameters, were determined and interpreted. Serum IMA levels were significantly higher in individuals with OSA compared with the control group (p=0.0003). CIMT was significantly higher in the OSA group compared with the control group (0.88± 0.26 mm vs 0.75±0.17 mm, p=0.005). The CIMT and serum IMA levels were positively correlated with the apnea-hypopnea index (r=0.35 and r=0.32, respectively), and with the oxygen desaturation index (r=0.34 and r=0.29, respectively) at baseline. Increased IMA levels and CIMT may be related to increased oxidative stress and risk of atherosclerosis in individuals with OSA.

Assessment of the role of serum ischemia-modified albumin in obstructive sleep apnea in comparison with interleukin-6

“…However, its possible role in OSA had not been clearly demonstrated yet. The number of studies focusing on this issue in the literature is limited [10,11,[26][27][28][29]. Yang et al [10] demonstrated a positive correlation between IMA levels and the OSA severity.…”

“…Regarding these correlations, they suggested that IMA could be a hypoxemic marker in OSA patients. Karamanli et al [26] stated that serum IMA levels were significantly higher in individuals with OSA compared with the control group with a similar body mass index and age. Sunnetcioglu et al [27] reported that IMA was significantly higher in subjects with OSA and independently associated with severity of OSA defined by AHI and severity of oxygen desaturation.…”

Analysis of the Ischemia-Modified Albumin as a Potential Biomarker for Cardiovascular Damage in Obstructive Sleep Apnea Patients with Acute Coronary Syndrome

“…In the evaluation of IMA levels in OSA patients with CV consequences, carotid intima media thickness has been evaluated, being significantly higher in the OSA group and positively correlated with the AHI and oxygen desaturation index (ODI). These results reflect that IMA, as an oxidative stress biomarker, is related to an increased risk of atherosclerosis production [47].…”