Background and Objectives
Few studies have assessed the possible interaction between and impact of IL‐6 variants and serum α‐tocopherol levels on periodontal condition in older individuals. Here, we assessed the relationship between IL‐6 variants and serum α‐tocopherol levels on periodontal condition by considering effect modification.
Material and Methods
Among the study participants, 359 who were 71 years of age underwent a dental examination, biochemical analysis, and interview. After dividing the participants into tertiles based on serum α‐tocopherol levels, we conducted Poisson regression analysis to compare the prevalence rate ratio (PRR) for periodontal disease markers with the IL‐6 genotype (rs1800796) based on each tertile adjusted by the number of teeth present (offset).
Results
The PRRs of the IL‐6 genotype for periodontal condition (probing pocket depth [PPD], clinical attachment level [CAL], and bleeding on probing [BOP]) which were adjusted by the number of teeth present (offset) were 1.17 (P < .001), 1.37 (P < .001), and 1.08 (P = .048), respectively. In addition, a significant association was found between the reciprocal number of PRRs of the IL‐6 genotype and three serum α‐tocopherol levels. The adjusted PRRs (± standard error) of the IL‐6 genotypes for PPD were 0.48 (0.12) for the first group (P < .001), 1.54 (0.04) for the second group (P < .001), and 2.11 (0.03) for the third group (P < .001); similar tendencies were seen for CAL and BOP.
Conclusion
The results of this study suggest a potential association between the IL‐6 genotype and periodontal condition in relation to serum antioxidant concentrations.