Influence of ofloxacin, norfloxacin, nalidixic acid, pyromidic acid and pipemidic acid on human γ-interferon production and blastogenesis

Simone, Claudio De; Baldinelli, L.; Ferrazzi, M.; Santis, Salvatore De; L, Pugnaloni; Sorice, F

doi:10.1093/jac/17.6.811

Cited by 25 publications

(13 citation statements)

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“…Cipro was unable to restore IFN-g production, but significantly upregulated LPS-stimulated splenocyte production of TNF-a, IL-1b and IL-6 compared with either non-Cipro-treated rats or controls. This is consistent with earlier findings with various quinolones at therapeutic levels (De Simone et al, 1986;Gollapudi et al, 1986;Bailly et al, 1991;Riesbeck and Forsgren, 1994;Katsuno et al, 2006). Cipro showed a consistent upregulation of IL-6 production of splenocytes in response to B-or T-cell mitogens, and this may be of benefit in chemotherapy-related sepsis as low Il-6 production from systemic immune compartments correlates with sepsis mortality (Adamik et al, 1997).…”

Section: Effects Of Cipro On Alterations Of Immune Competence After Csupporting

confidence: 90%

Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy

et al. 2009

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Infectious complications are a major cause of morbidity and mortality from dose-intensive cancer chemotherapy. In spite of the importance of intestinal bacteria translocation in these infections, information about the effect of high-dose chemotherapy on gut mucosal immunity is minimal. We studied prophylactic ciprofloxacin (Cipro) treatment on irinotecan (CPT-11) toxicity and host immunity in rats bearing Ward colon tumour. Cipro abolished chemotherapy-related mortality, which was 45% in animals that were not treated with Cipro. Although Cipro reduced body weight loss and muscle wasting, it was unable to prevent severe late-onset diarrhoea. Seven days after CPT-11, splenocytes were unable to proliferate (stimulation index ¼ 0.10 ± 0.02) and produce proliferative and inflammatory cytokines (i.e., Interleukin (IL)-2, interferon-g (IFN-g), tumour necrosis factor-a (TNF-a) IL-1b, IL-6) on mitogen stimulation in vitro (Po0.05 vs controls), whereas mesenteric lymph node (MLN) cells showed a hyper-proliferative response and a hyper-production of pro-inflammatory cytokines on mitogen stimulation. This suggests compartmentalised effects by CPT-11 chemotherapy on systemic and intestinal immunity. Cipro normalised the hyper-responsiveness of MLN cells, and in the spleen, it partially restored the proliferative response and normalised depressed production of IL-1b and IL-6. Taken together, Cipro prevented infectious challenges associated with immune hypo-responsiveness in systemic immune compartments, and it may also alleviate excessive pro-inflammatory responses mediating local gut injury.

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Section: Effects Of Cipro On Alterations Of Immune Competence After Csupporting

confidence: 90%

Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy

et al. 2009

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“…In studies in which the effects of quinolones on leukocyte function were measured, increased macrophage phagocytic capacity has been demonstrated by pefloxacin (3). In contrast, lymphocyte studies with quinolones have shown reduced mitogen-induced cell proliferation (difloxacin) and decreased DNA synthesis with norfloxacin and difloxacin (2,13). The effect of each quinolones on leukocyte function could not be clearly defined in our model.…”

Section: Discussioncontrasting

confidence: 61%

Effect of quinolones and other antimicrobial agents on cell-associated Legionella pneumophila

Havlichek

Saravolatz

Pohlod

1987

Antimicrob Agents Chemother

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We evaluated the in vitro susceptibility of Legionella pneumophila ATCC 33152 (serogroup I) to 13 antibiotics alone and in combination with rifampin (0.1 mg/liter) by three methods. Extracellular susceptibility was determined by MIC determinations and time kill curves in buffered yeast extract broth, while intracellular susceptibility was determined by peripheral human monocytes in RPMI 1640 culture medium. Antibiotic concentrations equal to or greater than the broth dilution MIC inhibited or killed L. pneumophila by-the time kill method, except this was not the case for trimethoprim-sulfamethoxazole. Antibiotic concentrations below the broth dilution MIC did not inhibit Legionella growth. The only antibiotic-rifampin combinations which produced improved killing of L. pneumophila by the time kill method were those in which the logarithmic growth of L. pneumophila occurred during the experiment (rosoxacin, amifloxacin, cinoxacin, trimethoprimsulfamethoxazole, clindamycin, and doxycycline). Neither direct MICs nor time kill curve assays accurately predicted intracellular L. pneumophila susceptibility. Rifampin, erythromycin, ciprofloxacin, rosoxacin, enoxacin, amifloxacin, gentamicin, clindamycin, and doxycycline all inhibited intracellular L. pneumophila growth at readily achievable concentrations in serum. Cefoxitin and thienamycin showed no inhibition of growth, although they were present extracellularly at concentrations that were 20 to 1,000 times their broth dilution MICs. Clindamycin was the only antibiotic that was able to inhibit intracellular L. pneumophila growth at an extracellular concentration below its MIC. The gentamicin (5 mg/liter)-rifampin combination was the only antibiotic-rifampin combination which demonstrated decreased cell-associated Legionella survival in this model of in vitro susceptibility.

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“…Forsgren and his group (8, 9, 10) have repeatedly reported an increase in JH-thymidine uptake by PHA and Con-A stimulated lymphocytes exposed to clinically relevant concentrations of ciprofloxacin and other quinolones. In contrast, other researches have found no change in uptake in ciprofloxacin exposed Iymphocytes or inhibition of uptake in cells exposed to ofloxacin, norfloxacin, pefloxacin and difloxacin (11,12,13). One possible explanation for these discordant results is the difference in incubation periods.…”

Section: Effect Of Quinolones On Human Lymphocytes Inmentioning

confidence: 78%

Immunological aspects of new quinolones

Shalit

1991

Eur. J. Clin. Microbiol. Infect. Dis.

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The effects of new quinolones on the immune system have been mainly studied in vitro. Despite some conflicting results due to variations in study methodologies, certain conclusions can be drawn. Clinically relevant concentrations of most quinolones seem to have no direct effect on isolated immune parameters such as phagocytic cell functions, lymphocyte proliferation, immunoglobulin production, gamma-interferon secretion and bone-marrow progenitor cell proliferation. In contrast, the production of certain cytokines (IL-1, IL-2) and colony stimulating factors by stimulated lymphocytes and splenocytes is enhanced in the presence of clinically achievable concentrations of the drugs. IL-2 production is also enhanced when higher concentrations of quinolones are added to stimulated lymphocytes. However, most other functions such as IL-1 and TNF production, and proliferation of lymphocytes and bone marrow progenitor cells are inhibited in vitro by concentrations of quinolones exceeding 50 micrograms/ml. In vivo studies on immunomodulatory effects of new quinolones are few and are generally in agreement with the in vitro findings. Only very high dosages administered to experimental animals cause suppressive effects, while therapeutic doses are usually not associated with measurable alterations in immune functions. Recent reports on stimulatory effects of therapeutic doses of ciprofloxacin on bone marrow myeloid progenitor cells in irradiated, neutropenic mice, warrant further investigations in experimental animals as well as in neutropenic and bone marrow transplant patients treated with the new quinolones.

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Influence of ofloxacin, norfloxacin, nalidixic acid, pyromidic acid and pipemidic acid on human γ-interferon production and blastogenesis

Cited by 25 publications

References 0 publications

Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy

Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy

Effect of quinolones and other antimicrobial agents on cell-associated Legionella pneumophila

Immunological aspects of new quinolones

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