Influence of olfactory bulb removal on ingestive behaviors, activity levels and self-stimulation in hamsters.

Kt, Borer; Jb, Powers; Winans, SS; Es, Valenstein

doi:10.1037/h0035931

Cited by 13 publications

(4 citation statements)

References 28 publications

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“…To the extent that ambulation in an open field reflects an animal's general activity level, our data are in accord with Borer et al's (1974) observation that bilateral bulbectomy reduced running-disk activity in male and female hamsters. However, behavior in an open field has been reported to be influenced by an animal's emotional responsiveness, and its propensity to explore a novel environment (Whimbey & Denenberg, 1967).…”

Section: Discussionsupporting

confidence: 80%

“…Social behaviors that are altered by bulbectomy include sexual behavior in male mice (Rowe & Edwards, 1972), rats (Bermant & Taylor, 1969 ;Heimer & Larsson, 1967), and hamsters (Murphy & Schneider, 1970); sexual behavior in female mice and rats (Edwards & Warner, 1972;Moss, 1971); and aggressive behavior in male mice (Ropartz , 1968;Rowe & Edwards, 1971) and hamsters (Murphy & Schneider, 1970). Among the nonsocial behaviors that have been found to be affected by bulbectomy are active and passive avoidance learning in rats (Sieck, 1972;Sieck & Gordon, 1972, 1973, open-field activity in rats (Sieck, 1972), running-disk activity in hamsters (Borer, Powers, Winans, & Valenstein, 1974), and handling reactivity in rats (Douglas, Isaacson, & Moss, 1969) and hamsters (Goodman & Firestone, 1973).…”

mentioning

confidence: 99%

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Olfactory bulb ablation: Effects on handling reactivity, open-field behavior, and agonistic behavior in male and female hamsters

Hilger

Rowe

1975

Psychobiology

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Bilateral olfactory bulb ablation resulted in increased handling reactivity, and decreased open-field ambulation and intraspecific aggressiveness in male and female hamsters. Bulbectomy-induced increases in handling reactivity were greater in female than in male hamsters. However, bulbectomy-induced deficits in open-field ambulation and aggressive behavior were greater in males than in females. Bulbectomy-induced increases in handling reactivity were transient in both males and females. Furthermore, bulbectomized females regained preoperative levels of open-field ambulation by the second postoperative week. In contrast, bulbectomized males exhibited levels of open-field ambulation that were below preoperative levels in all but the third postoperative week. In bulbectomized males, aggressiveness was suppressed for the duration of postoperative testing.

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Section: Discussionsupporting

confidence: 80%

mentioning

confidence: 99%

Olfactory bulb ablation: Effects on handling reactivity, open-field behavior, and agonistic behavior in male and female hamsters

Hilger

Rowe

1975

Psychobiology

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“…Ten adult female hamsters anesthetized with sodium pentobarbital (75 mg/kg, IP) had stainless steel stimulation electrodes implanted in lateral hypothalamic sites found previously to support intracranial self-stimulation [8]. A Kopf stereotaxic instrument held the skull horizontal between bregma and lambda.…”

Section: Electrode Lmphmtationmentioning

confidence: 99%

Opiate-receptor blockade reduces voluntary running but not self-stimulation in hamsters

Potter¹,

Borer²,

Katz³

1983

Pharmacology Biochemistry and Behavior

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Naltrexone HCl, a long-acting opiate receptor blocker was administered to female hamsters at two doses, 10 and 20 mg/kg, IP prior to 12 hr of nocturnal running or every 12 hr during access to hypothalamic self-stimulation to determine whether endogenous opiates played a role in either of these two motivated behaviors. Naltrexone suppressed total running activity and speed, and caused an increase in pause time but did not affect the rate of hypothalamic self-stimulation. Furthermore, weight gain was unaffected by four weeks of self-stimulation but was accelerated during two weeks of voluntary running. Thus stimulation of endogenous opiate receptors helps support high levels of voluntary running but is not involved in initiation of running or in maintenance of intracranial self-stimulation in female hamsters. Furthermore, the association of opiate receptor stimulation and increased somatic growth with voluntary running but not with self-stimulation suggests a possible facilitatory role for endogenous opiates in acceleration of growth by exercise.

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“…Sedentary hamsters were individually housed in suspended cages at all times. Exercising hamsters also occupied suspended cages except for the duration of voluntary activity, at which time they were individually housed in Plexiglas boxes (30 cm wide, 40 cm deep and 32 cm high) with a permanently mounted horizontal disc exerciser, 25 cm in diameter [1,11]. The hamsters were allowed to adjust to the dietary options for seven days.…”

Section: Animalsmentioning

confidence: 99%

Absence of weight regulation in exercising hamsters☆

Borer

1974

Physiology & Behavior

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Spontaneous activity on horizontal discs causes a permanent upward displacement of hamster weight, length, and, under some circumstances, percentage body fat. This phenomenon manifests itself through an immediate increase in the rate of weight gain, a disappearance of a preference for sunflower seeds, as well as in a delayed and gradual increase in food intake during and immediately following the activity period. A week after termination of spontaneous disc running normal regulation of body weight is reinstated and maintained at the new elevated weight level. These results suggest that some concomitant of spontaneous disc running in hamsters renders the weight-regulatory mechanisms inoperative.

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Influence of olfactory bulb removal on ingestive behaviors, activity levels and self-stimulation in hamsters.

Cited by 13 publications

References 28 publications

Olfactory bulb ablation: Effects on handling reactivity, open-field behavior, and agonistic behavior in male and female hamsters

Olfactory bulb ablation: Effects on handling reactivity, open-field behavior, and agonistic behavior in male and female hamsters

Opiate-receptor blockade reduces voluntary running but not self-stimulation in hamsters

Absence of weight regulation in exercising hamsters☆

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