Influence of olive leaves extract on hepatorenal injury in streptozotocin diabetic rats

Abstract

Medicinal plants have always been an important source of new alternative effective compounds for human therapy. Currently, there are many of scientific evidences indicate that the medicinal plants contain a lot of hypoglycemic chemical compounds. The purpose of the present study was to determine the influence of olive leaves extract on hepatorenal injury in diabetic male rats. Experimental diabetes was induced by streptozotocin (STZ). The levels of serum glucose, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, total bilirubin, creatinine, blood urea nitrogen, uric acid and malondialdehyde were significantly increased, while the levels of serum superoxide dismutase, glutathione and catalase were statistically decreased in untreated diabetic rats. Moreover, the histopathological examination showed several alterations in the structure of liver and kidney in untreated diabetic rats. Treatments with low dose and high dose of olive leaves extract in diabetic rats showed remarkable reducing and protecting influences of physiological and histopathological alterations. Moreover, the highly treatment efficiency was noted in diabetic rats treated with high dose followed by low dose of olive leaves extract. Additionally, the results of this study proved that the antioxidant activities of olive leaves extract played a vital role against the hepatorenal injury induced by diabetes. Finally, this study indicates to the importance of the use of olive leaves extract as promising alternative and complementary therapeutic agent against diabetes and its complications.

Effect of Moringa and Olive Leaves Powder Consumption on Hyperglycemic State in Type 2 Diabetes Mellitus (A Pilot Study)

“…This study is consistent with previous studies that showed that an inverse relationship between vegetable intake and 2-hour glucose concentration in OGTT was found, but the analyses were only adjusted for cohort, age, BMI, and energy intake [29]. Also in a crosssectional study of a Canadian native population a protective effect of vegetables on impaired glucose tolerance or T2D was reported [30].…”

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

“…BUN and creatinine are both excreted by the kidney. Hence, impairment of kidney function results in the accumulation of BUN and creatinine in the blood (Al‐Attar & Alsalmi, 2017). Treatment with T. triandra caused a decrease in the BUN and creatinine levels.…”

Effect of Ethanolic Olive Leaves Extract on the Renal Cortex of Adult Diabetic Male Albino Rats

“…al., 2016). Antioxidant activities of the olive leaf extracts played a fundamental role against the renal damage induced by diabetes (Al-Attar and Alsalmi, 2019b). These studies were confirmed by the study of Ağgül et.…”